{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:36:37Z","timestamp":1789763797561,"version":"4.0.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"DOI":"10.1210\/jc.2013-3686","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T10:06:36Z","timestamp":1389693996000},"page":"843-851","source":"Crossref","is-referenced-by-count":45,"title":["The Effects of Levothyroxine Replacement or Suppressive Therapy on Health Status, Mood, and Cognition"],"prefix":"10.1210","volume":"99","author":[{"given":"Mary H.","family":"Samuels","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Clinical Nutrition (M.H.S., I.K., A.S., K.G.S.), Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kolobova","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Clinical Nutrition (M.H.S., I.K., A.S., K.G.S.), Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Smeraglio","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Clinical Nutrition (M.H.S., I.K., A.S., K.G.S.), Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Peters","sequence":"additional","affiliation":[{"name":"Division of Biostatistics (D.P.), Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeri S.","family":"Janowsky","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurosciences (J.S.J.), Oregon Health & Science University, Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn G.","family":"Schuff","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Clinical Nutrition (M.H.S., I.K., A.S., K.G.S.), Portland, Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113383843500_B1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/thy.2009.0311","article-title":"Benefits of thyrotropin suppression versus the risks of adverse effects in differentiated thyroid cancer","volume":"20","author":"Biondi","year":"2010","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t2019041113383843500_B2","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1210\/jc.2007-1957","article-title":"Health status, mood, and cognition in experimentally induced subclinical thyrotoxicosis","volume":"93","author":"Samuels","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383843500_B3","first-page":"760","article-title":"Cognitive functions and mood during chronic thyrotropin-suppressive therapy with L-thyroxine in patients with differentiated thyroid carcinoma","volume":"35","author":"Jaracz","year":"2012","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2019041113383843500_B4","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1530\/eje.1.02047","article-title":"Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment","volume":"153","author":"Tagay","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383843500_B5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1365-2265.2006.02458.x","article-title":"Quality of life in longterm exogenous subclinical hyperthyroidism and the effects of restoration of euthyroidism, a randomized controlled trial","volume":"64","author":"Eustatia-Rutten","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383843500_B6","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1677\/erc.0.0100601","article-title":"Quality of life and psychometric functionality in patients with differentiated thyroid carcinoma","volume":"10","author":"Botella-Carretero","year":"2003","journal-title":"Endocr Relat Cancer"},{"key":"key\n\t\t\t\t2019041113383843500_B7","first-page":"596","article-title":"Psychiatric and cognitive effects of hypothyroidism","volume-title":"The Thyroid","author":"Schuff","year":"2012","edition":"10th ed"},{"key":"key\n\t\t\t\t2019041113383843500_B8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11011-010-9208-8","article-title":"Structural and functional alterations in the hippocampus due to hypothyroidism","volume":"25","author":"Koromilas","year":"2010","journal-title":"Metab Brain Dis"},{"key":"key\n\t\t\t\t2019041113383843500_B9","first-page":"90","volume-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Spreen","year":"1998"},{"key":"key\n\t\t\t\t2019041113383843500_B10","first-page":"612","volume-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Spreen","year":"1998"},{"key":"key\n\t\t\t\t2019041113383843500_B11","first-page":"644","volume-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Spreen","year":"1998"},{"key":"key\n\t\t\t\t2019041113383843500_B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/s15327752jpa6001_1","article-title":"The diagnosis and assessment of depression, mania, and psychosis by self-report","volume":"60","author":"Wetzler","year":"1993","journal-title":"J Pers Assess"},{"key":"key\n\t\t\t\t2019041113383843500_B13","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/1097-4679(198909)45:5<786::AID-JCLP2270450515>3.0.CO;2-P","article-title":"The affective lability scales: development, reliability, and validity","volume":"45","author":"Harvey","year":"1989","journal-title":"J Clin Psychol"},{"key":"key\n\t\t\t\t2019041113383843500_B14","first-page":"444","volume-title":"Neuropsychological Assessment","author":"Lezak","year":"1995"},{"key":"key\n\t\t\t\t2019041113383843500_B15","first-page":"363","volume-title":"Neuropsychological Assessment","author":"Lezak","year":"1995"},{"key":"key\n\t\t\t\t2019041113383843500_B16","first-page":"208","volume-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Spreen","year":"1998"},{"key":"key\n\t\t\t\t2019041113383843500_B17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0006-3223(98)00336-9","article-title":"Declarative and procedural memory in bipolar disorder","volume":"46","author":"van Gorp","year":"1999","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t2019041113383843500_B18","first-page":"1043","volume-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Spreen","year":"1998"},{"key":"key\n\t\t\t\t2019041113383843500_B19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1017\/S1355617704103081","article-title":"Cancellation test performance in African American, Hispanic, and White elderly","volume":"10","author":"Byrd","year":"2004","journal-title":"J Int Neuropsychol Soc"},{"key":"key\n\t\t\t\t2019041113383843500_B20","first-page":"371","volume-title":"Neuropsychological Assessment","author":"Lezak","year":"1995"},{"key":"key\n\t\t\t\t2019041113383843500_B21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1196\/annals.1401.023","article-title":"The role of orbitofrontal cortex in decision making: a component process account","volume":"1121","author":"Fellows","year":"2007","journal-title":"Ann NY Acad Sci"},{"key":"key\n\t\t\t\t2019041113383843500_B22","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand J Statist"},{"key":"key\n\t\t\t\t2019041113383843500_B23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1507\/endocrj.51.311","article-title":"Assessment of anxiety in subclinical thyroid disorders","volume":"51","author":"Sait G\u00f6nen","year":"2004","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t2019041113383843500_B24","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF02191961","article-title":"Subclinical hyperthyroidism: physical and mental state of patients","volume":"241","author":"Schlote","year":"1992","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"key\n\t\t\t\t2019041113383843500_B25","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/BF01667147","article-title":"Psychopathological and neuropsychological symptoms in patients with subclinical and remitted hyperthyroidism","volume":"68","author":"Bommer","year":"1990","journal-title":"Klin Wochenschr"},{"key":"key\n\t\t\t\t2019041113383843500_B26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.arcmed.2005.05.008","article-title":"Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction","volume":"37","author":"Gulseren","year":"2006","journal-title":"Arch Med Res"},{"key":"key\n\t\t\t\t2019041113383843500_B27","first-page":"4701","article-title":"Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patients","volume":"85","author":"Biondi","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383843500_B28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-145-8-200610170-00006","article-title":"Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction?","volume":"145","author":"Roberts","year":"2006","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113383843500_B29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1530\/EJE-11-0430","article-title":"Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals","volume":"165","author":"de Jongh","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383843500_B30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1034\/j.1600-0447.2002.01250.x","article-title":"An association between depression, anxiety and thyroid function\u2014a clinical fact or an artefact?","volume":"106","author":"Engum","year":"2002","journal-title":"Acta Psychiatr Scand"},{"key":"key\n\t\t\t\t2019041113383843500_B31","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/JGP.0b013e31820dcad5","article-title":"Thyroid hormones and depression: the Health in Men study","volume":"19","author":"Almeida","year":"2011","journal-title":"Am J Geriatr Psychiatry"},{"key":"key\n\t\t\t\t2019041113383843500_B32","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1365-2265.2008.03521.x","article-title":"A paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study","volume":"71","author":"Panicker","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383843500_B33","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1089\/thy.2011.0200","article-title":"Is there a relationship between fatigue perception and the serum levels of thyrotropin and free thyroxine in euthyroid subjects?","volume":"22","author":"van de Ven","year":"2012","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t2019041113383843500_B34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1023\/B:QURE.0000015315.35184.66","article-title":"Health-related quality of life in patients with thyroid disorders","volume":"13","author":"Bianchi","year":"2004","journal-title":"Qual Life Res"},{"key":"key\n\t\t\t\t2019041113383843500_B35","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1210\/jc.2006-0099","article-title":"Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being, or quality of life: results of a double-blind, randomized clinical trial","volume":"91","author":"Walsh","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383843500_B36","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1530\/eje.1.02025","article-title":"Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism","volume":"153","author":"Wekking","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383843500_B37","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-2265.2002.01654.x","article-title":"Psychological well-being in patients on \u2018adequate\u2019 doses of l-thyroxine: results of a large, controlled community-based questionnaire study","volume":"57","author":"Saravanan","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113383843500_B38","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1210\/jc.2011-3399","article-title":"Combination treatment with T4 and T3: toward personalized replacement therapy in hypothyroidism?","volume":"97","author":"Biondi","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113383843500_B39","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1530\/EJE-09-0606","article-title":"Treated hypothyroidism, cognitive function, and depressed mood in old age: the Rancho Bernardo Study","volume":"161","author":"Kramer","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113383843500_B40","doi-asserted-by":"crossref","first-page":"412","DOI":"10.7326\/0003-4819-142-6-200503150-00007","article-title":"Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing l-thyroxine plus liothyronine with l-thyroxine alone","volume":"142","author":"Escobar-Morreale","year":"2005","journal-title":"Ann Intern Med"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/3\/843\/11157948\/jcem0843.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T13:25:00Z","timestamp":1565097900000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/3\/843\/2537543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,1]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-3686","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,1]]}}}