{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:35:52Z","timestamp":1759541752851},"reference-count":30,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":815,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"DOI":"10.1210\/jc.2013-4108","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T14:42:44Z","timestamp":1402065764000},"page":"E1602-E1609","source":"Crossref","is-referenced-by-count":11,"title":["A New Type of Natural Bispecific Antibody With Potential Protective Effect in Hashimoto Thyroiditis"],"prefix":"10.1210","volume":"99","author":[{"given":"Wenli","family":"Li","sequence":"first","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"},{"name":"Graduate School (W.L., G.F., L.C.), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaowei","family":"Fan","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"},{"name":"Graduate School (W.L., G.F., L.C.), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida","family":"Chen","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"},{"name":"Graduate School (W.L., G.F., L.C.), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guigao","family":"Lin","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehong","family":"Xie","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lunan","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinming","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Clinical Laboratories (W.L., G.F., L.C., R.Z., K.Z., Y.S., G.L., J.X., L.W., J.L.), Beijing Hospital, Beijing 100029, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113321752300_B1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1073\/pnas.63.1.78","article-title":"The covalent structure of an entire \u03b3G immunoglobulin molecule","volume":"63","author":"Edelman","year":"1969","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113321752300_B2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1046\/j.1365-2567.1999.00845.x","article-title":"Normal human immunoglobulin G4 is bispecific: it has two different antigen-combining sites","volume":"97","author":"Schuurman","year":"1999","journal-title":"Immunology"},{"key":"key\n\t\t\t\t2019041113321752300_B3","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1126\/science.1144603","article-title":"Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange","volume":"317","author":"van der Neut","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t2019041113321752300_B4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2222.2009.03207.x","article-title":"Immunoglobulin G4: an odd antibody","volume":"39","author":"Aalberse","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"key\n\t\t\t\t2019041113321752300_B5","doi-asserted-by":"crossref","first-page":"10302","DOI":"10.1021\/ja203638y","article-title":"Mechanism of immunoglobulin G4 Fab-arm exchange","volume":"133","author":"Rispens","year":"2011","journal-title":"J Am Chem Soc"},{"key":"key\n\t\t\t\t2019041113321752300_B6","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.1371\/journal.pone.0010879","article-title":"Production of native bispecific antibodies in rabbits","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019041113321752300_B7","doi-asserted-by":"crossref","first-page":"16527","DOI":"10.1371\/journal.pone.0016527","article-title":"Identification of natural bispecific antibodies against cyclic citrullinated peptide and immunoglobulin G in rheumatoid arthritis","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019041113321752300_B8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2249.2008.03756.x","article-title":"Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status","volume":"154","author":"Xie","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t2019041113321752300_B9","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2741\/3720","article-title":"Thyroperoxidase, thyroglobulin, Na(+)\/I(\u2212) symporter, pendrin in thyroid autoimmunity","volume":"16","author":"Czarnocka","year":"2011","journal-title":"Front Biosci (Landmark Ed)"},{"key":"key\n\t\t\t\t2019041113321752300_B10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/BOR.0b013e328341378c","article-title":"Hashimoto's thyroiditis: old concepts and new insights","volume":"23","author":"Li","year":"2011","journal-title":"Curr Opin Rheumatol"},{"key":"key\n\t\t\t\t2019041113321752300_B11","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/modpathol.2012.68","article-title":"Distinct histopathological features of Hashimoto's thyroiditis with respect to IgG4-related disease","volume":"25","author":"Li","year":"2012","journal-title":"Mod Pathol"},{"key":"key\n\t\t\t\t2019041113321752300_B12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1507\/endocrj.EJ11-0309","article-title":"IgG4-related disease of the thyroid glands","volume":"59","author":"Kakudo","year":"2012","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t2019041113321752300_B13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJMra1104650","article-title":"IgG4-related disease","volume":"366","author":"Stone","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113321752300_B14","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0019-2791(71)90395-8","article-title":"Peroxidase labelled antibody and Fab conjugates with enhanced intracellular penetration","volume":"8","author":"Avrameas","year":"1971","journal-title":"Immunochemistry"},{"key":"key\n\t\t\t\t2019041113321752300_B15","first-page":"83","volume-title":"The ELISA Guide Book","author":"Crowther","year":"1995"},{"key":"key\n\t\t\t\t2019041113321752300_B16","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1365-2265.2009.03640.x","article-title":"Initial thyroid status and cardiovascular risk factors: the EPIC-Norfolk prospective population study","volume":"72","author":"Boekholdt","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113321752300_B17","first-page":"118","article-title":"Determination of IgG subclasses and avidity of antithyroid peroxidase antibodies in patients with subclinical hypothyroidism\u2014a comparison with patients with overt hypothyroidism","volume":"59","author":"Silva","year":"2003","journal-title":"Horm Res"},{"issue":"1","key":"key\n\t\t\t\t2019041113321752300_B18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2249.2010.04155.x","article-title":"Avidity of thyroglobulin antibody in sera from patients with Hashimoto's thyroiditis with different thyroidfunctional status","volume":"161","author":"Zhang","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"key\n\t\t\t\t2019041113321752300_B19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/08916930410001705394","article-title":"Autoimmune thyroid disease","volume":"37","author":"Weetman","year":"2004","journal-title":"Autoimmunity"},{"key":"key\n\t\t\t\t2019041113321752300_B20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/PAP.0b013e3182534868","article-title":"Hashimoto thyroiditis: a century later","volume":"19","author":"Ahmed","year":"2012","journal-title":"Adv Anat Pathol"},{"key":"key\n\t\t\t\t2019041113321752300_B21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1365-2249.1991.tb02956.x","article-title":"Anti-human thyroid peroxidase and anti-human thyroglobulin antibodies present no cross-reactivity on recombinant peptides","volume":"86","author":"Henry","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t2019041113321752300_B22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2012.10.029","article-title":"Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange","volume":"54","author":"Davies","year":"2012","journal-title":"Mol Immunol"},{"key":"key\n\t\t\t\t2019041113321752300_B23","doi-asserted-by":"crossref","first-page":"e42942","DOI":"10.1371\/journal.pone.0042942","article-title":"Human milk IgGs contain various combinations of different antigen-binding sites resulting in multiple variants of their bispecificity","volume":"7","author":"Sedykh","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019041113321752300_B24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000319873","article-title":"Distribution of IgG4- and\/or IgG-positive plasma cells in Hashimoto's thyroiditis: an immunohistochemical study","volume":"77","author":"Kojima","year":"2010","journal-title":"Pathobiology"},{"key":"key\n\t\t\t\t2019041113321752300_B25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/jclinpath-2011-200485","article-title":"Fibrosing variant of Hashimoto thyroiditis is an IgG4 related disease","volume":"65","author":"Deshpande","year":"2012","journal-title":"J Clin Pathol"},{"issue":"2","key":"key\n\t\t\t\t2019041113321752300_B26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s12020-013-9988-9","article-title":"Serum levels of IgG and IgG4 in Hashimoto thyroiditis","volume":"45","author":"Kawashima","year":"2014","journal-title":"Endocrine"},{"key":"key\n\t\t\t\t2019041113321752300_B27","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1210\/jc.2009-1794","article-title":"Distinct clinical, serological, and sonographic characteristics of Hashimoto's thyroiditis based with and without IgG4-positive plasma cells","volume":"95","author":"Li","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113321752300_B28","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/art.11025","article-title":"C-reactive protein as a regulator of autoimmunity and inflammation","volume":"48","author":"Du Clos","year":"2003","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t2019041113321752300_B29","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1042\/bj3340489","article-title":"Regulation of serum amyloid A protein expression during the acute-phase response","volume":"334","author":"Jensen","year":"1998","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t2019041113321752300_B30","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1089\/jir.2011.0049","article-title":"Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity","volume":"31","author":"Ganesh","year":"2011","journal-title":"J Interferon Cytokine Res"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/9\/E1602\/20288607\/jcem1602.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T14:09:25Z","timestamp":1649254165000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/9\/E1602\/2537376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,1]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-4108","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,1]]}}}