{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:37:42Z","timestamp":1787186262884,"version":"build-2736575974"},"reference-count":40,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"DOI":"10.1210\/jc.2013-4111","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T15:27:22Z","timestamp":1397489242000},"page":"2549-2556","source":"Crossref","is-referenced-by-count":26,"title":["Serum Estradiol Associates With Blood Hemoglobin in Elderly Men: The MrOS Sweden Study"],"prefix":"10.1210","volume":"99","author":[{"given":"Catharina","family":"Lewerin","sequence":"first","affiliation":[{"name":"Section of Hematology and Coagulation, Department of Internal Medicine, Institute of Medicine (C.L., H.N.-E.), 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Nilsson-Ehle","sequence":"additional","affiliation":[{"name":"Section of Hematology and Coagulation, Department of Internal Medicine, Institute of Medicine (C.L., H.N.-E.), 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Jacobsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Transfusion Medicine (S.J.), 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Johansson","sequence":"additional","affiliation":[{"name":"Center for Bone and Arthritis Research (CBAR), Geriatric Medicine at the Institute of Medicine (H.J., V.S., M.L., D.M.), Sahlgrenska Academy at the University of Gothenburg, 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter","family":"Sundh","sequence":"additional","affiliation":[{"name":"Center for Bone and Arthritis Research (CBAR), Geriatric Medicine at the Institute of Medicine (H.J., V.S., M.L., D.M.), Sahlgrenska Academy at the University of Gothenburg, 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus K.","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Clinical and Molecular Osteoporosis Research Unit (M.K.K.), Department of Clinical Sciences and Orthopaedics, Lund University, SE-20502 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Lorentzon","sequence":"additional","affiliation":[{"name":"Center for Bone and Arthritis Research (CBAR), Geriatric Medicine at the Institute of Medicine (H.J., V.S., M.L., D.M.), Sahlgrenska Academy at the University of Gothenburg, 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Barrett-Connor","sequence":"additional","affiliation":[{"name":"Department of Family and Preventative Medicine (E.B.-C.), University of California, San Diego, California 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Vandenput","sequence":"additional","affiliation":[{"name":"CBAR (L.V., C.O.), Department of Internal Medicine and Clinical Nutrition, at the Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, SE-411 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"CBAR (L.V., C.O.), Department of Internal Medicine and Clinical Nutrition, at the Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, SE-411 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Mellstr\u00f6m","sequence":"additional","affiliation":[{"name":"Center for Bone and Arthritis Research (CBAR), Geriatric Medicine at the Institute of Medicine (H.J., V.S., M.L., D.M.), Sahlgrenska Academy at the University of Gothenburg, 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113351858400_B1","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3324\/haematol.2010.023101","article-title":"Prevalence, incidence and types of mild anemia in the elderly: the \u201cHealth and Anemia\u201d population-based study","volume":"95","author":"Tettamanti","year":"2010","journal-title":"Haematologica"},{"key":"key\n\t\t\t\t2019041113351858400_B2","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/j.amjmed.2003.12.009","article-title":"Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature","volume":"116","author":"Begh\u00e9","year":"2004","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t2019041113351858400_B3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.blre.2005.12.002","article-title":"Anemia in the elderly: current understanding and emerging concepts","volume":"20","author":"Eisenstaedt","year":"2006","journal-title":"Blood Rev"},{"key":"key\n\t\t\t\t2019041113351858400_B4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/MOH.0b013e3283522471","article-title":"Anemia in the elderly","volume":"19","author":"Pang","year":"2012","journal-title":"Curr Opin Hematol"},{"key":"key\n\t\t\t\t2019041113351858400_B5","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1046\/j.1532-5415.51.3s.4.x","article-title":"Epidemiology of anemia in the elderly: information on diagnostic evaluation","volume":"51","author":"Balducci","year":"2003","journal-title":"J Am Geriatr Soc"},{"key":"key\n\t\t\t\t2019041113351858400_B6","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1182\/blood-2004-05-1812","article-title":"Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia","volume":"104","author":"Guralnik","year":"2004","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113351858400_B7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1034\/j.1600-0609.2000.065005297.x","article-title":"Blood haemoglobin declines in the elderly: implications for reference intervals from age 70 to 88","volume":"65","author":"Nilsson-Ehle","year":"2000","journal-title":"Eur J Haematol"},{"key":"key\n\t\t\t\t2019041113351858400_B8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1600-0609.1995.tb00227.x","article-title":"Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects","volume":"55","author":"Nilsson-Ehle","year":"1995","journal-title":"Eur J Haematol"},{"key":"key\n\t\t\t\t2019041113351858400_B9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1054\/blre.2001.0146","article-title":"Anemia and aging: an overview of clinical, diagnostic and biological issues","volume":"15","author":"Carmel","year":"2001","journal-title":"Blood Rev"},{"key":"key\n\t\t\t\t2019041113351858400_B10","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0025-7125(16)31963-0","article-title":"Anemia in thyroid diseases","volume":"59","author":"Fein","year":"1975","journal-title":"Med Clin North Am"},{"key":"key\n\t\t\t\t2019041113351858400_B11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-0609.2004.00374.x","article-title":"Insulin-like growth factor-1 is a predictor of blood haemoglobin concentration in 70-yr-old subjects","volume":"74","author":"Nilsson-Ehle","year":"2005","journal-title":"Eur J Haematol"},{"key":"key\n\t\t\t\t2019041113351858400_B12","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1210\/jc.2005-1830","article-title":"Testosterone and estradiol among older men","volume":"91","author":"Orwoll","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351858400_B13","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1046\/j.1365-2265.2000.01159.x","article-title":"Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: cross-sectional data from a healthy male cohort","volume":"53","author":"Leifke","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113351858400_B14","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1001\/archinte.166.13.1380","article-title":"Low testosterone levels and the risk of anemia in older men and women","volume":"166","author":"Ferrucci","year":"2006","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019041113351858400_B15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1056\/NEJM197307122890205","article-title":"Androgens and erythropoiesis","volume":"289","author":"Shahidi","year":"1973","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113351858400_B16","first-page":"3469","article-title":"Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men","volume":"84","author":"Dobs","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351858400_B17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2165\/00002512-199915020-00006","article-title":"Risks versus benefits of testosterone therapy in elderly men","volume":"15","author":"Basaria","year":"1999","journal-title":"Drugs Aging"},{"key":"key\n\t\t\t\t2019041113351858400_B18","first-page":"227","article-title":"Aplastic anemia: research themes and clinical issues","volume":"12","author":"Young","year":"1981","journal-title":"Prog Hematol"},{"key":"key\n\t\t\t\t2019041113351858400_B19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/tam.5.2.98.102","article-title":"Estradiol in elderly men","volume":"5","author":"Vermeulen","year":"2002","journal-title":"Aging Male"},{"key":"key\n\t\t\t\t2019041113351858400_B20","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.1210\/jc.2004-0735","article-title":"Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: the Troms\u00f8 Study","volume":"89","author":"Bj\u00f8rnerem","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351858400_B21","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/gerona\/gls216","article-title":"Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study","volume":"68","author":"Jasuja","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key\n\t\t\t\t2019041113351858400_B22","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1210\/jc.2012-2265","article-title":"Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men","volume":"97","author":"Yeap","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351858400_B23","first-page":"1086","article-title":"Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men","volume":"79","author":"B\u00e9langer","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351858400_B24","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.2164\/jandrol.111.015651","article-title":"Association between sex steroid hormones and hematocrit in a nationally representative sample of men","volume":"33","author":"Paller","year":"2012","journal-title":"J Androl"},{"key":"key\n\t\t\t\t2019041113351858400_B25","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1359\/jbmr.080518","article-title":"Older men with low serum estradiol and high serum SHBG have an increased risk of fractures","volume":"23","author":"Mellstr\u00f6m","year":"2008","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113351858400_B26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0895-4356(93)90053-4","article-title":"The Physical Activity Scale for the Elderly (PASE): development and evaluation","volume":"46","author":"Washburn","year":"1993","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t2019041113351858400_B27","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1359\/jbmr.061018","article-title":"Serum levels of specific glucuronidated androgen metabolites predict BMD and prostate volume in elderly men","volume":"22","author":"Vandenput","year":"2007","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113351858400_B28","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jsbmb.2006.02.004","article-title":"Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women","volume":"99","author":"Labrie","year":"2006","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key\n\t\t\t\t2019041113351858400_B29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2796.2006.01732.x","article-title":"Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly","volume":"261","author":"Lewerin","year":"2007","journal-title":"J Intern Med"},{"key":"key\n\t\t\t\t2019041113351858400_B30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/0004563212474939","article-title":"Holotranscobalamin is not influenced by decreased renal function in elderly men: the MrOS Sweden study","volume":"50","author":"Lewerin","year":"2013","journal-title":"Ann Clin Biochem"},{"key":"key\n\t\t\t\t2019041113351858400_B31","article-title":"Springer Series in Statistics: Regression Modeling Strategies With Applications to Linear Models, Logistic Regression, and Survival Analysis","author":"Harrell","year":"2001"},{"key":"key\n\t\t\t\t2019041113351858400_B32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2141.1989.tb04303.x","article-title":"Decline of blood haemoglobin in the aged: a longitudinal study of an urban Swedish population from age 70 to 81","volume":"71","author":"Nilsson-Ehle","year":"1989","journal-title":"Br J Haematol"},{"key":"key\n\t\t\t\t2019041113351858400_B33","first-page":"3276","article-title":"Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men","volume":"85","author":"van den Beld","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351858400_B34","article-title":"Differential associations of testosterone, dihydrotestosterone and estradiol with physical, metabolic and health-related factors in community-dwelling men aged 17\u201397 years from the Busselton Health Survey [published online January 16, 2014]","author":"Yeap","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113351858400_B35","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1530\/EJE-09-0696","article-title":"Serum estradiol is associated with lean mass in elderly Swedish men","volume":"162","author":"Vandenput","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113351858400_B36","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1206168","article-title":"Gonadal steroids and body composition, strength, and sexual function in men","volume":"369","author":"Finkelstein","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113351858400_B37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.7326\/0003-4819-153-10-201011160-00004","article-title":"Long-term effects of dihydrotestosterone treatment on prostate growth in healthy, middle-aged men without prostate disease: a randomized, placebo-controlled trial","volume":"153","author":"Idan","year":"2010","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041113351858400_B38","doi-asserted-by":"crossref","first-page":"e40465","DOI":"10.1371\/journal.pone.0040465","article-title":"Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes","volume":"7","author":"Ikeda","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019041113351858400_B39","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.gene.2012.09.060","article-title":"Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element","volume":"511","author":"Hou","year":"2012","journal-title":"Gene"},{"key":"key\n\t\t\t\t2019041113351858400_B40","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1210\/en.2011-2045","article-title":"17\u03b2-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site","volume":"153","author":"Yang","year":"2012","journal-title":"Endocrinology"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/7\/2549\/17638383\/jcem2549.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T14:10:42Z","timestamp":1565359842000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/7\/2549\/2538024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-4111","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]}}}