{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T22:11:46Z","timestamp":1772316706639,"version":"3.50.1"},"reference-count":35,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Although there is evidence of metabolic risks in young women with irregular menses and androgen excess, persistence of risks after menopause is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of the study was to determine the impact of menopause on the cardiometabolic profile in women with high androgens and a history of menstrual irregularity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Study of Women's Health Across the Nation is a longitudinal cohort study. Data from 1929 women without metabolic syndrome (MetS) at baseline were analyzed for incidence of MetS, self-reported stroke, and myocardial infarction. Cox hazard ratios (HRs) were estimated, adjusting for age, ethnicity, body mass, smoking, menopausal status, and study site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among MetS-free women at baseline, 497 new cases were identified during 20 249 woman-years of follow-up over 12 years. Women with hyperandrogenemia (HA) and oligomenorrhea (Oligo) developed incident cases of MetS at a comparable rate compared with their counterparts: eumenorrheic, normoandrogenic women [HR 1.4 (0.9\u20132.2)], oligomenorrheic, normoandrogenic women [HR 1.3 (0.8\u20132.2)], and eumenorrheic hyperandrogenic women [HR 1.2 (0.7\u20131.8)]. Smoking and obesity were the strongest predictors of incident MetS. There was no significant difference in incidence of self-reported stroke or MI by HA\/Oligo status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Longitudinal evidence suggests that a history of androgen excess and menstrual irregularity is not associated with worsening of metabolic health after menopause. Our findings challenge the notion that a history of concurrent HA and Oligo reflects ongoing cardiometabolic risk in postmenopausal women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2013-4170","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T12:59:22Z","timestamp":1392123562000},"page":"2120-2127","source":"Crossref","is-referenced-by-count":35,"title":["Hyperandrogenic Oligomenorrhea and Metabolic Risks Across Menopausal Transition"],"prefix":"10.1210","volume":"99","author":[{"given":"Alex J.","family":"Polotsky","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology (A.J.P., A.A.A., N.S.), Aurora, Colorado 80045;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda A.","family":"Allshouse","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology (A.J.P., A.A.A., N.S.), Aurora, Colorado 80045;"},{"name":"University of Colorado Denver, and Department of 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