{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:56:24Z","timestamp":1791082584731,"version":"4.1.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"DOI":"10.1210\/jc.2013-4249","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T19:36:21Z","timestamp":1396899381000},"page":"E1199-E1208","source":"Crossref","is-referenced-by-count":32,"title":["NIS Mediates Iodide Uptake in the Female Reproductive Tract and Is a Poor Prognostic Factor in Ovarian Cancer"],"prefix":"10.1210","volume":"99","author":[{"given":"Garcilaso","family":"Riesco-Eizaguirre","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (G.R.-E., S.G.L., M.A.E.-C., P.S.), Consejo Superior de Investigaciones Cient\u00edficas (CSIC-UAM) 28029 Madrid, Spain"},{"name":"Servicio de Endocrinolog\u00eda y Nutrici\u00f3n (G.R-E.), 28046, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana Garcia","family":"Leoni","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (G.R.-E., S.G.L., M.A.E.-C., P.S.), Consejo Superior de Investigaciones Cient\u00edficas (CSIC-UAM) 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mendiola","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Patologica (M.M., D.H.), 28046, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angeles","family":"Estevez-Cebrero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (G.R.-E., S.G.L., M.A.E.-C., P.S.), Consejo Superior de Investigaciones Cient\u00edficas (CSIC-UAM) 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Ines","family":"Gallego","sequence":"additional","affiliation":[{"name":"Unidad de Patolog\u00eda Mamaria (M.I.G.), 28220,Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Redondo","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda Medica (A.R.), Hospital Universitario La Paz, IdPAZ, 28046, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hardisson","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Patologica (M.M., D.H.), 28046, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Santisteban","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (G.R.-E., S.G.L., M.A.E.-C., P.S.), Consejo Superior de Investigaciones Cient\u00edficas (CSIC-UAM) 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De la Vieja","sequence":"additional","affiliation":[{"name":"Unidad de Tumores Endocrinos (A.D.l.V.), Unidad Funcional de Investigaci\u00f3n en Enfermedades Cr\u00f3nicas (UFIEC), Instituto de Salud Carlos III, 28220,Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113351915700_B1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1210\/er.2001-0029","article-title":"The sodium\/iodide Symporter (NIS): characterization, regulation, and medical significance","volume":"24","author":"Dohan","year":"2003","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113351915700_B2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pharmthera.2012.06.007","article-title":"The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics","volume":"135","author":"Kogai","year":"2012","journal-title":"Pharmacol Ther"},{"key":"key\n\t\t\t\t2019041113351915700_B3","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1530\/eje.1.02257","article-title":"A perspective view of sodium iodide symporter research and its clinical implications","volume":"155","author":"Riesco-Eizaguirre","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113351915700_B4","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.2000.80.3.1083","article-title":"Molecular analysis of the sodium\/iodide symporter: impact on thyroid and extrathyroid pathophysiology","volume":"80","author":"De La Vieja","year":"2000","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t2019041113351915700_B5","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1210\/me.2002-0109","article-title":"A thyroid-specific far-upstream enhancer in the human sodium\/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3\u2032,5\u2032-monophosphate response element-like sequence binding proteins for full activity and is differentially regulated in normal and thyroid cancer cells","volume":"16","author":"Taki","year":"2002","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t2019041113351915700_B6","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1128\/MCB.19.3.2051","article-title":"The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium\/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription","volume":"19","author":"Ohno","year":"1999","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t2019041113351915700_B7","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/78630","article-title":"The mammary gland iodide transporter is expressed during lactation and in breast cancer","volume":"6","author":"Tazebay","year":"2000","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041113351915700_B8","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1210\/jc.2002-021544","article-title":"Immunohistochemical profile of the sodium\/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections","volume":"88","author":"Wapnir","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351915700_B9","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1158\/0008-5472.CAN-12-0516","article-title":"Iodide transporter NIS regulates cancer cell motility and invasiveness by interacting with the Rho guanine nucleotide exchange factor LARG","volume":"72","author":"Lacoste","year":"2012","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t2019041113351915700_B10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2174\/156800910791054194","article-title":"The biology of the sodium iodide symporter and its potential for targeted gene delivery","volume":"10","author":"Hingorani","year":"2010","journal-title":"Curr Cancer Drug Targets"},{"key":"key\n\t\t\t\t2019041113351915700_B11","doi-asserted-by":"crossref","first-page":"E1435","DOI":"10.1210\/jc.2010-2373","article-title":"Telomerase-driven expression of the sodium iodide symporter (NIS) for in vivo radioiodide treatment of cancer: a new broad-spectrum NIS-mediated antitumor approach","volume":"96","author":"Riesco-Eizaguirre","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351915700_B12","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s00259-008-0775-4","article-title":"The potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer","volume":"35","author":"Willhauck","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"key\n\t\t\t\t2019041113351915700_B13","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1210\/endo.138.8.5262","article-title":"Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter","volume":"138","author":"Smanik","year":"1997","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113351915700_B14","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/ijc.20649","article-title":"Ovarian cancer in Europe: cross-sectional trends in incidence and mortality in 28 countries, 1953\u20132000","volume":"113","author":"Bray","year":"2005","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t2019041113351915700_B15","first-page":"415","article-title":"The biology of ovarian cancer: new opportunities for translation. Nature reviews","volume":"9","author":"Bast","year":"2009","journal-title":"Cancer"},{"key":"key\n\t\t\t\t2019041113351915700_B16","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1097\/01.MP.0000095646.70007.6A","article-title":"Tissue microarray immunohistochemical expression analysis of mismatch repair (hMLH1 and hMSH2 genes) in endometrial carcinoma and atypical endometrial hyperplasia: relationship with microsatellite instability","volume":"16","author":"Hardisson","year":"2003","journal-title":"Mod Pathol"},{"key":"key\n\t\t\t\t2019041113351915700_B17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ydbio.2012.09.005","article-title":"Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland","volume":"372","author":"Garcia-Zaragoza","year":"2012","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t2019041113351915700_B18","first-page":"79","article-title":"Estrogen and progesterone receptor detection in archival formalin-fixed, paraffin-embedded tissue from breast carcinoma: a comparison of immunohistochemistry with the dextran-coated charcoal assay","volume":"5","author":"Wilbur","year":"1992","journal-title":"Mod Pathol"},{"key":"key\n\t\t\t\t2019041113351915700_B19","first-page":"1052","article-title":"Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods","volume":"49","author":"Kinsel","year":"1989","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t2019041113351915700_B20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/modpathol.2009.167","article-title":"The prognostic value of Ki67 is dependent on estrogen receptor status and histological grade in premenopausal patients with node-negative breast cancer","volume":"23","author":"Klintman","year":"2010","journal-title":"Mod Pathol"},{"key":"key\n\t\t\t\t2019041113351915700_B21","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1210\/me.2011-0038","article-title":"Regulation of thyroid oxidative state by thioredoxin reductase has a crucial role in thyroid responses to iodide excess","volume":"25","author":"Leoni","year":"2011","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t2019041113351915700_B22","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1210\/me.2005-0162","article-title":"Molecular analysis of a congenital iodide transport defect: G543E impairs maturation and trafficking of the Na+\/I\u2212 symporter","volume":"19","author":"De la Vieja","year":"2005","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t2019041113351915700_B23","first-page":"632","article-title":"Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA","volume":"6","author":"Chen","year":"1988","journal-title":"Biotechniques"},{"key":"key\n\t\t\t\t2019041113351915700_B24","first-page":"234","article-title":"Autosomal dominant transmission of congenital thyroid hypoplasia due to loss-of-function mutation of PAX8","volume":"86","author":"Vilain","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351915700_B25","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1093\/emboj\/cdf412","article-title":"Targeting of SWI\/SNF chromatin remodelling complexes to estrogen-responsive genes","volume":"21","author":"Belandia","year":"2002","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t2019041113351915700_B26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1210\/endo-96-1-219","article-title":"The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy","volume":"96","author":"Smith","year":"1975","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113351915700_B27","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.bbrc.2006.05.049","article-title":"Unliganded estrogen receptor-\u03b1 activates transcription of the mammary gland Na+\/I\u2212 symporter gene","volume":"345","author":"Alotaibi","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t2019041113351915700_B28","first-page":"241","article-title":"Susceptibility of Candida albicans to peroxidase-catalyzed oxidation products of thiocyanate, iodide and bromide","volume":"20","author":"Majerus","year":"1992","journal-title":"J Biol Bucc"},{"key":"key\n\t\t\t\t2019041113351915700_B29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/026010600902000204","article-title":"Iodine in evolution of salivary glands and in oral health","volume":"20","author":"Venturi","year":"2009","journal-title":"Nutr Health"},{"key":"key\n\t\t\t\t2019041113351915700_B30","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/thy.2009.0110","article-title":"Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t2019041113351915700_B31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1210\/jcem-69-1-186","article-title":"Temporary ovarian failure in thyroid cancer patients after thyroid remnant ablation with radioactive iodine","volume":"69","author":"Raymond","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113351915700_B32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2265.2005.02218.x","article-title":"Outcome of radioiodine-131 therapy in hyperfunctioning thyroid nodules: a 20 years' retrospective study","volume":"62","author":"Ceccarelli","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113351915700_B33","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1530\/eje.1.02158","article-title":"European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium","volume":"154","author":"Pacini","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113351915700_B34","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/105072504323150732","article-title":"Gene therapy for thyroid cancer: current status and future prospects","volume":"14","author":"Spitzweg","year":"2004","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t2019041113351915700_B35","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1158\/1078-0432.CCR-12-2243","article-title":"New strategies in the treatment of ovarian cancer: current clinical perspectives and future potential","volume":"19","author":"Banerjee","year":"2013","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t2019041113351915700_B36","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1038\/onc.2009.349","article-title":"Radiation carcinogenesis: lessons from Chernobyl","volume":"27","author":"Williams","year":"2008","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t2019041113351915700_B37","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1371\/journal.pmed.0050232","article-title":"Ovarian carcinoma subtypes are different diseases: implications for biomarker studies","volume":"5","author":"Kobel","year":"2008","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t2019041113351915700_B38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ygyno.2006.08.052","article-title":"Emerging roles for PAX8 in ovarian cancer and endosalpingeal development","volume":"104","author":"Bowen","year":"2007","journal-title":"Gynecol Oncol"},{"key":"key\n\t\t\t\t2019041113351915700_B39","doi-asserted-by":"crossref","first-page":"x16","DOI":"10.1093\/annonc\/mdt463","article-title":"Origin and molecular pathogenesis of ovarian high-grade serous carcinoma","volume":"24","author":"Kurman","year":"2013","journal-title":"Ann Oncol"},{"key":"key\n\t\t\t\t2019041113351915700_B40","doi-asserted-by":"crossref","first-page":"12372","DOI":"10.1073\/pnas.1109363108","article-title":"Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer","volume":"108","author":"Cheung","year":"2011","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/7\/E1199\/17637904\/jcem1199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T09:06:01Z","timestamp":1565341561000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/7\/E1199\/2537372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-4249","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]}}}