{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:02:52Z","timestamp":1778644972162,"version":"3.51.4"},"reference-count":24,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Anti-Mullerian hormone (AMH) is believed to validly reflect the ovarian reserve. We wanted to test whether congenital absence of gonadotropin stimulation of the ovaries affects AMH production.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>The objective of the study was to test the validity of AMH as a marker for the ovarian reserve in females with congenital multiple pituitary hormone deficiency (MPHD; deficiency of three or more axes).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p>This was a retrospective laboratory study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting:<\/jats:title>\n                  <jats:p>The study was conducted in the Department of Pediatric Endocrinology in a tertiary center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients:<\/jats:title>\n                  <jats:p>The AMH serum levels were assessed in females with congenital (n = 16; median age 12.5 y, range 0.7\u201331 y) or acquired (n = 20; 18.5 y, range 2\u201333 y) MPHD and in controls with short stature (n = 100; 9.7 y, range 2\u201317 y).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure:<\/jats:title>\n                  <jats:p>AMH was measured by AMH Gen II ELISA from Beckmann Coulter.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>In the controls, AMH ranged between 1.8 (P3) and 67.8 pmol\/L (P97). Three patients with a severe form of congenital MPHD were AMH deficient, whereas the other 33 patients with MPHD had normal AMH levels. There was significantly more AMH deficiency in congenital than in acquired MPHD (P &amp;lt; .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Most girls with MPHD have normal serum AMH levels. However, some females with severe congenital MPHD are AMH deficient. This deficiency might be the result of the total absence of gonadotropins. In these females, AMH is unlikely to be an accurate prognostic parameter of the efficacy of fertility treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2013-4250","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T16:28:51Z","timestamp":1395073731000},"page":"E1045-E1049","source":"Crossref","is-referenced-by-count":18,"title":["Anti-Mullerian Hormone Deficiency in Girls With Congenital Multiple Pituitary Hormone Deficiency"],"prefix":"10.1210","volume":"99","author":[{"given":"Beate","family":"Deubzer","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology (B.D., K.W., R.S., G.B.), University Children's Hospital T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology (B.D., K.W., R.S., G.B.), University Children's Hospital T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Lawrenz","sequence":"first","affiliation":[{"name":"Department of Gynecological Endocrinology and Reproductive Medicine (B.L.), University Women's Hospital, 72076 T\u00fcbingen, Germany (now FakihIVF, Abu Dhabi, United Arab Emirates)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Schweizer","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology (B.D., K.W., R.S., G.B.), University Children's Hospital T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Binder","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology (B.D., K.W., R.S., G.B.), University Children's Hospital T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071613103003300_B1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/humrep\/der446","article-title":"Anti-Mullerian hormone: clairvoyance or crystal clear?","volume":"27","author":"Nelson","year":"2012","journal-title":"Hum Reprod"},{"key":"2020071613103003300_B2","first-page":"152","article-title":"Mullerian inhibiting substance: a gonadal hormone with multiple functions","volume":"14","author":"Lee","year":"1993","journal-title":"Endocr Rev"},{"key":"2020071613103003300_B3","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/humrep\/deq019","article-title":"Concentrations of AMH and inhibin-B in relation to follicular diameter in normal human small antral follicles","volume":"25","author":"Andersen","year":"2010","journal-title":"Hum Reprod"},{"key":"2020071613103003300_B4","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1093\/humrep\/del165","article-title":"Anti-Mullerian hormone inhibits initiation of growth of human primordial ovarian follicles in vitro","volume":"21","author":"Carlsson","year":"2006","journal-title":"Hum Reprod"},{"key":"2020071613103003300_B5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/humrep\/dep366","article-title":"Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts","volume":"25","author":"van Disseldorp","year":"2010","journal-title":"Hum Reprod"},{"key":"2020071613103003300_B6","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1210\/jc.2010-0930","article-title":"Serum levels of anti-Mullerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients","volume":"95","author":"Hagen","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613103003300_B7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1210\/jcem-40-4-545","article-title":"Pituitary-gonadal relations in infancy. I. Patterns of serum gonadotropin concentrations from birth to four years of age in man and chimpanzee","volume":"40","author":"Winter","year":"1975","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613103003300_B8","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1210\/jc.2011-1502","article-title":"Postnatal developmental changes in the pituitary-ovarian axis in preterm and term infant girls","volume":"96","author":"Kuiri-H\u00e4nninen","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613103003300_B9","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.fertnstert.2011.06.016","article-title":"Evaluation of serum antimullerian hormone and inhibin B concentrations in the differential diagnosis of secondary oligoamenorrhea","volume":"96","author":"Li","year":"2011","journal-title":"Fertil Steril"},{"key":"2020071613103003300_B10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10815-012-9759-1","article-title":"Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism","volume":"29","author":"S\u00f6nmezer","year":"2012","journal-title":"J Assist Reprod Genet"},{"key":"2020071613103003300_B11","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1210\/jc.2011-0368","article-title":"The role of anti-Mullerian hormone (AMH) in assessing ovarian reserve","volume":"96","author":"Tran","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613103003300_B12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.rbmo.2012.03.010","article-title":"Anti-Mullerian hormone in woman with hypopituitarism diagnosed before or during adolescence","volume":"25","author":"Sonntag","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"2020071613103003300_B13","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1210\/jc.2011-3180","article-title":"Anti-Mullerian hormone is a marker of gonadotoxicity in pre- and postpubertal girls treated for cancer: a prospective study","volume":"97","author":"Brougham","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613103003300_B14","first-page":"49","article-title":"Reference ranges of lutropin and follitropin in the luliberin test in prepubertal and pubertal children using a monoclonal immunoradiometric assay","volume":"28","author":"Partsch","journal-title":"J Clin Chem Clin Biochem"},{"key":"2020071613103003300_B15","first-page":"30","article-title":"Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders: comparison with the gonadotropin-releasing hormone test","volume":"78","author":"Ib\u00e1\u00f1ez","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613103003300_B16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1210\/jcem-73-1-79","article-title":"Hypothalamic-pituitary dysfunction in growth hormone-deficient patients with pituitary abnormalities","volume":"73","author":"Maghnie","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613103003300_B17","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s00381-005-1246-x","article-title":"Endocrine manifestations of craniopharyngioma","volume":"21","author":"Halac","year":"2005","journal-title":"Childs Nerv Sys"},{"key":"2020071613103003300_B18","first-page":"247","article-title":"Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-\u03b2 superfamily","volume":"7","author":"Wilson","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2020071613103003300_B19","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1210\/me.2010-0273","article-title":"Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-\u03b2","volume":"24","author":"di Clemente","year":"2010","journal-title":"Mol Endocrinol"},{"key":"2020071613103003300_B20","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1093\/humrep\/des260","article-title":"Anti-Mullerian hormone: poor assay reproducibility in a large cohort of subjects suggests sample instability","volume":"27","author":"Rustamov","year":"2012","journal-title":"Hum Reprod"},{"key":"2020071613103003300_B21","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1095\/biolreprod.105.039602","article-title":"Gonadotropin control of inhibin secretion and the relationship to follicle type and number in the hpg mouse","volume":"73","author":"Wang","year":"2005","journal-title":"Biol Reprod"},{"key":"2020071613103003300_B22","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1101\/gad.9.16.2007","article-title":"Targeted disruption of the pituitary glycoprotein hormone \u03b1-subunit produces hypogonadal and hypothyroid mice","volume":"9","author":"Kendall","year":"1995","journal-title":"Genes Dev"},{"key":"2020071613103003300_B23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.repbio.2013.06.003","article-title":"Growth and antrum formation of bovine primary follicles in long-term culture in vivo","volume":"13","author":"Sun","year":"2013","journal-title":"Reprod Biol"},{"key":"2020071613103003300_B24","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/humrep\/14.6.1555","article-title":"Effects of follicle-stimulating hormone and serum substitution on the in-vitro growth of human ovarian follicles","volume":"14","author":"Wright","year":"1999","journal-title":"Hum Reprod"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/6\/E1045\/9045290\/jcem1045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/6\/E1045\/9045290\/jcem1045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T23:14:56Z","timestamp":1594941296000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/6\/E1045\/2537313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,1]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2013-4250","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,1]]}}}