{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:31:32Z","timestamp":1761895892293},"reference-count":42,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Calcification of the arterial wall in diabetes contributes to the arterial occlusive process occurring below the knee. The osteoprotegerin (OPG)\/receptor activator of nuclear factor \u03baB ligand (RANKL) system is suspected to be involved in the calcification process.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>The aim of the study was to investigate whether there is a link between arterial calcification in type 2 diabetes and 1) conventional cardiovascular risk factors, 2) serum RANKL and OPG levels, and 3) neuropathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and Methods:<\/jats:title>\n                  <jats:p>We objectively scored, in a cross-sectional study, infrapopliteal vascular calcification using computed tomography scanning in 198 patients with type 2 diabetes, a high cardiovascular risk, and a glomerular filtration rate &amp;gt;30 mL\/min. Color duplex ultrasonography was performed to assess peripheral arterial occlusive disease, and mediacalcosis. Peripheral neuropathy was defined by a neuropathy disability score &amp;gt;6. RANKL and OPG were measured in the serum by routine chemistry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Below-knee arterial calcification was associated with arterial occlusive disease. In multivariate logistic regression analysis, the variables significantly and independently associated with the calcification score were age (odds ratio [OR] = 1.08; 95% confidence interval [CI] = 1.04\u20131.13; P &amp;lt; .0001), male gender (OR = 3.53; 95% CI = 1.54\u20138.08; P = .003), previous cardiovascular disease (OR = 2.78; 95% CI = 1.39\u20135.59; P = .005), and neuropathy disability score (per 1 point, OR = 1.21; 95% CI = 1.05\u20131.38; P = .006). The association with ln OPG, significantly associated with calcification score in univariate analysis (OR = 3.14; 95% CI = 1.05\u20139.40; P = .045), was no longer significant in multivariate analysis. RANKL and OPG\/RANKL were not significantly associated with the calcification score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Below-knee arterial calcification severity is clearly correlated with peripheral neuropathy severity and with several usual cardiovascular risk factors, but not with serum RANKL level.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2014-1047","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T15:49:24Z","timestamp":1405093764000},"page":"4250-4258","source":"Crossref","is-referenced-by-count":23,"title":["Below-Knee Arterial Calcification in Type 2 Diabetes: Association With Receptor Activator of Nuclear Factor \u03baB Ligand, Osteoprotegerin, and Neuropathy"],"prefix":"10.1210","volume":"99","author":[{"given":"Olivier","family":"Bourron","sequence":"first","affiliation":[{"name":"Diabetes and Metabolic Diseases (O.B., C.E.A., S.J., A.H.), 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9s (O.B., P.C., M.K., A.H.), Universit\u00e9 Pierre et Marie Curie University Paris 06, Paris, France"},{"name":"Institute of Cardiometabolism and Nutrition (O.B., P.C., M.K., A.H.), 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole Elodie","family":"Aubert","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolic Diseases (O.B., C.E.A., S.J., A.H.), 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Liabeuf","sequence":"additional","affiliation":[{"name":"Inserm U1088 (S.L., R.M., M.B., Z.A.M.), Unit\u00e9 de formation et de recherche de M\u00e9decine et Pharmacie, Jules Verne Universit\u00e9 of Picardy, Amiens, France"},{"name":"Clinical Research Centre Division of Clinical Pharmacology (S.L.), Amiens University Hospital and the Jules Verne University of Picardy, 80000 Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Cluzel","sequence":"additional","affiliation":[{"name":"Radiology (P.C.), 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9s (O.B., P.C., M.K., A.H.), Universit\u00e9 Pierre et Marie Curie University Paris 06, Paris, France"},{"name":"Institute of Cardiometabolism and Nutrition (O.B., P.C., M.K., A.H.), 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Lajat-Kiss","sequence":"additional","affiliation":[{"name":"Vascular Surgery (F.L.-K., M.D.), 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Dadon","sequence":"additional","affiliation":[{"name":"Vascular Surgery (F.L.-K., M.D.), 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Komajda","sequence":"additional","affiliation":[{"name":"Cardiology (M.K.), 75013 Paris, France"},{"name":"Sorbonne Universit\u00e9s (O.B., P.C., M.K., A.H.), Universit\u00e9 Pierre et Marie Curie University Paris 06, Paris, France"},{"name":"Institute of Cardiometabolism and Nutrition (O.B., P.C., M.K., A.H.), 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romuald","family":"Mentaverri","sequence":"additional","affiliation":[{"name":"Inserm U1088 (S.L., R.M., M.B., Z.A.M.), Unit\u00e9 de formation et de recherche de M\u00e9decine et Pharmacie, Jules Verne Universit\u00e9 of Picardy, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Brazier","sequence":"additional","affiliation":[{"name":"Inserm U1088 (S.L., R.M., M.B., Z.A.M.), Unit\u00e9 de formation et de recherche de M\u00e9decine et Pharmacie, Jules Verne Universit\u00e9 of Picardy, Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Pierucci","sequence":"additional","affiliation":[{"name":"Biostatistics and Clinical Research (A.P.), 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Morel","sequence":"additional","affiliation":[{"name":"Departments and Laboratory of Biochemistry (F.M.), Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Jacqueminet","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolic Diseases (O.B., C.E.A., S.J., A.H.), 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad A.","family":"Massy","sequence":"additional","affiliation":[{"name":"Division of Nephrology (Z.A.M.), Ambroise Par\u00e9 Hospital, 92100 Boulogne-Billancourt, 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