{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:33:46Z","timestamp":1777394026461,"version":"3.51.4"},"reference-count":46,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"DOI":"10.1210\/jc.2014-1243","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T16:55:02Z","timestamp":1396284902000},"page":"2592-2598","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacokinetic-Pharmacodynamic Study of Subcutaneous Injection of Depot Nandrolone Decanoate Using Dried Blood Spots Sampling Coupled With Ultrapressure Liquid Chromatography Tandem Mass Spectrometry Assays"],"prefix":"10.1210","volume":"99","author":[{"given":"Gurmeet K. S.","family":"Singh","sequence":"first","affiliation":[{"name":"Andrology Department (G.K.S.S., L.T., M.J., D.J.H.), Concord Hospital, Sydney, New South Wales 2139, Australia"},{"name":"Faculty of Pharmacy (G.K.S.S.), Universiti Teknologi MARA, Bandar Puncak Alam, Selangor, 42300 Malaysia"},{"name":"ANZAC Research Institute (G.K.S.S., R.D., M.J., D.J.H.), University of Sydney, Sydney New South Wales 2139, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Turner","sequence":"additional","affiliation":[{"name":"Andrology Department (G.K.S.S., L.T., M.J., D.J.H.), Concord Hospital, Sydney, New South Wales 2139, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"Desai","sequence":"additional","affiliation":[{"name":"ANZAC Research Institute (G.K.S.S., R.D., M.J., D.J.H.), University of Sydney, Sydney New South Wales 2139, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Andrology Department (G.K.S.S., L.T., M.J., D.J.H.), Concord Hospital, Sydney, New South Wales 2139, Australia"},{"name":"ANZAC Research Institute (G.K.S.S., R.D., M.J., D.J.H.), University of Sydney, Sydney New South Wales 2139, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Handelsman","sequence":"additional","affiliation":[{"name":"Andrology Department (G.K.S.S., L.T., M.J., D.J.H.), Concord Hospital, Sydney, New South Wales 2139, Australia"},{"name":"ANZAC Research Institute (G.K.S.S., R.D., M.J., D.J.H.), University of Sydney, Sydney New South Wales 2139, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113384404900_B1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1210\/endo-21-5-649","article-title":"Treatment of sexual underdevelopment with synthetic male hormone substance","volume":"21","author":"Hamilton","year":"1937","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113384404900_B2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1515\/bchm2.1935.237.1-3.89","article-title":"Uber die umwandlung des dehydroandrosterons in androstenol-(17)-one-(3) (Testosterone); umweg zur darstellung des testosterons aus cholsterin (vorlauf mitteilung)","volume":"237","author":"Butenandt","year":"1935","journal-title":"Zeischrift Physiologische Chemie"},{"key":"key\n\t\t\t\t2019041113384404900_B3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1515\/bchm2.1935.233.5-6.281","article-title":"Uber krystallinisches mannliches Hormon aus Hoden (Testosteron), wirksamer als aus Harn oder aus Cholestrin bereitetes Androsteron","volume":"233","author":"David","year":"1935","journal-title":"Hoppe Seylers Zeischrift Physiologische Chemie"},{"key":"key\n\t\t\t\t2019041113384404900_B4","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/hlca.193501801176","article-title":"Uber die krystallische Herstellung des Testikelhormons, Testosteron (androsten-3-on-17-ol)","volume":"18","author":"Ruzicka","year":"1935","journal-title":"Helv Chim Acta"},{"key":"key\n\t\t\t\t2019041113384404900_B5","first-page":"2469","article-title":"2010 Androgen Physiology, Pharmacology and Abuse","volume-title":"Endocrinology","author":"Handelsman","edition":"6th ed"},{"key":"key\n\t\t\t\t2019041113384404900_B6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/aja.2010.1","article-title":"Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate","volume":"12","author":"Sartorius","year":"2010","journal-title":"Asian J Androl"},{"key":"key\n\t\t\t\t2019041113384404900_B7","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/oxfordjournals.humrep.a136051","article-title":"Tolerability of intramuscular injections of testosterone ester in an oil vehicle","volume":"10","author":"Mackey","year":"1995","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041113384404900_B8","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1210\/jc.2008-1846","article-title":"Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men","volume":"94","author":"Gu","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113384404900_B9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1600-0773.1979.tb02404.x","article-title":"Studies on the fate of vegetable oil after intramuscular injection into experimental animals","volume":"45","author":"Svendsen","year":"1979","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"key\n\t\t\t\t2019041113384404900_B10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-0773.1980.tb01856.x","article-title":"Microscopic evidence of lymphogenic absorption of oil in humans receiving neuroleptic oily depot preparations intramuscularly","volume":"47","author":"Svendsen","year":"1980","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"key\n\t\t\t\t2019041113384404900_B11","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/jsm.12114","article-title":"Medication adherence and treatment patterns for hypogonadal patients treated with topical testosterone therapy: a retrospective medical claims analysis","volume":"10","author":"Schoenfeld","year":"2013","journal-title":"J Sex Med"},{"key":"key\n\t\t\t\t2019041113384404900_B12","volume-title":"1982 Pharmacokinetics","author":"Gibaldi","edition":"2nd ed"},{"key":"key\n\t\t\t\t2019041113384404900_B13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-3565(24)36598-X","article-title":"Pharmacokinetics and pharmacodynamics of nandrolone esters in oil vehicle: effects of ester, injection site and volume","volume":"281","author":"Minto","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t2019041113384404900_B14","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/clinchem\/43.8.1408","article-title":"Use of filter paper for sample collection and transport in steroid pharmacology","volume":"43","author":"Howe","year":"1997","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113384404900_B15","first-page":"1657","article-title":"Pharmacokinetics of human follicle-stimulating hormone in gonadotropin-deficient men","volume":"80","author":"Handelsman","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113384404900_B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajhb.22463","article-title":"Development and validation of assay protocols for use with dried blood spot samples","volume":"26","author":"McDade","year":"2014","journal-title":"Am J Hum Biol"},{"key":"key\n\t\t\t\t2019041113384404900_B17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jpba.2008.05.010","article-title":"Simultaneous determination of 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone in dried blood spots from low birth weight infants using LC-MS\/MS","volume":"48","author":"Higashi","year":"2008","journal-title":"J Pharm Biomed Anal"},{"key":"key\n\t\t\t\t2019041113384404900_B18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cca.2009.09.003","article-title":"Development and validation of a sensitive liquid chromatography-tandem mass spectrometry assay to simultaneously measure androgens and estrogens in serum without derivatization","volume":"409","author":"Harwood","year":"2009","journal-title":"Clinica Chimica Acta"},{"key":"key\n\t\t\t\t2019041113384404900_B19","article-title":"2001 Guidance for industry, bioanalytical method validation","author":"Food and Drug Administration"},{"key":"key\n\t\t\t\t2019041113384404900_B20","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1353\/dem.2007.0038","article-title":"What a drop can do: dried blood spots as a minimally invasive method for integrating biomarkers into population-based research","volume":"44","author":"McDade","year":"2007","journal-title":"Demography"},{"key":"key\n\t\t\t\t2019041113384404900_B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1096-8644(199709)104:1<1::AID-AJPA1>3.0.CO;2-V","article-title":"Hormone measures in finger-prick blood spot samples: new field methods for reproductive endocrinology","volume":"104","author":"Worthman","year":"1997","journal-title":"Am J Phys Anthropol"},{"key":"key\n\t\t\t\t2019041113384404900_B22","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.jchromb.2011.03.048","article-title":"Simultaneous quantification of 17\u03b1-OH progesterone, 11-deoxycortisol, \u03944-androstenedione, cortisol and cortisone in newborn blood spots using liquid chromatography-tandem mass spectrometry","volume":"879","author":"Magnisali","year":"2011","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"key\n\t\t\t\t2019041113384404900_B23","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.fertnstert.2006.12.016","article-title":"A comparison of blood spot vs. plasma analysis of gonadotropin and ovarian steroid hormone levels in reproductive-age women","volume":"88","author":"Edelman","year":"2007","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041113384404900_B24","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.4155\/bio.11.235","article-title":"Thinking about dried blood spots for pharmacokinetic assays and therapeutic drug monitoring","volume":"3","author":"Kissinger","year":"2011","journal-title":"Bioanalysis"},{"key":"key\n\t\t\t\t2019041113384404900_B25","first-page":"380","article-title":"Long-acting steroids in reproduction","volume":"13","author":"Junkman","year":"1957","journal-title":"Recent Prog Horm Res"},{"key":"key\n\t\t\t\t2019041113384404900_B26","first-page":"1843","article-title":"Subcutaneous administration of testosterone. A pilot study report","volume":"27","author":"Al-Futaisi","year":"2006","journal-title":"Saudi Med J"},{"key":"key\n\t\t\t\t2019041113384404900_B27","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1210\/jc.2004-1526","article-title":"Pharmacokinetic evaluation of three different intramuscular doses of nandrolone decanoate: analysis of serum and urine samples in healthy men","volume":"90","author":"Bagchus","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113384404900_B28","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1056\/NEJM198208053070607","article-title":"Intramuscular or intralipomatous injections?","volume":"307","author":"Cockshott","year":"1982","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113384404900_B29","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/archfami.3.2.146","article-title":"Injection granulomas. Intramuscle or intrafat?","volume":"3","author":"Haramati","year":"1994","journal-title":"Arch Fam Med"},{"key":"key\n\t\t\t\t2019041113384404900_B30","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejrad.2006.01.008","article-title":"Intramuscular injections into the buttocks: are they truly intramuscular?","volume":"58","author":"Chan","year":"2006","journal-title":"Eur J Radiol"},{"key":"key\n\t\t\t\t2019041113384404900_B31","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1136\/bmj.38706.742731.47","article-title":"Intramuscular gluteal injections in the increasingly obese population: retrospective study","volume":"332","author":"Nisbet","year":"2006","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041113384404900_B32","first-page":"72","article-title":"Computed tomographic measurement of gluteal subcutaneous fat thickness in reference to failure of gluteal intramuscular injections","volume":"58","author":"Burbridge","year":"2007","journal-title":"Can Assoc Radiol J"},{"key":"key\n\t\t\t\t2019041113384404900_B33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4040\/jkan.2010.40.2.247","article-title":"[Gluteal subcutaneous fat thickness measured by computed tomography as an estimate of proper gluteal intramuscular injections in Korean adults]","volume":"40","author":"Joo","year":"2010","journal-title":"J Korean Acad Nurs"},{"key":"key\n\t\t\t\t2019041113384404900_B34","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/MPA.0b013e318279d552","article-title":"Improving the success rate of gluteal intramuscular injections","volume":"42","author":"Boyd","year":"2013","journal-title":"Pancreas"},{"key":"key\n\t\t\t\t2019041113384404900_B35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0773.1985.tb00014.x","article-title":"Local toxicity of different drugs after intramuscular or intralipomatous injection in pigs: serum concentrations after three different formulations of cis(Z)-clopenthixol. Acta Pharmacol","volume":"57","author":"Svendsen","year":"1985","journal-title":"Toxicol (Copenh)"},{"key":"key\n\t\t\t\t2019041113384404900_B36","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/clinchem\/43.5.731","article-title":"Detection of anabolic steroid administration: ratio of urinary testosterone to epitestosterone vs the ratio of urinary testosterone to luteinizing hormone","volume":"43","author":"Perry","year":"1997","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113384404900_B37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1210\/er.2011-1035","article-title":"Growth hormone doping in sports: a critical review of use and detection strategies","volume":"33","author":"Baumann","year":"2012","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113384404900_B38","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1600-0773.1983.tb01104.x","article-title":"Local muscle damage and oily vehicles: a study on local reactions in rabbits after intramuscular injection of neuroleptic drugs in aqueous or oily vehicles","volume":"52","author":"Svendsen","year":"1983","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"key\n\t\t\t\t2019041113384404900_B39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1365-2265.1997.2521050.x","article-title":"Analysis of testosterone implants for androgen replacement therapy","volume":"47","author":"Handelsman","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113384404900_B40","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1365-2265.2001.01357.x","article-title":"Influence of implantation site and track geometry on the extrusion rate and pharmacology of testosterone implants","volume":"55","author":"Kelleher","year":"2001","journal-title":"Clin Endocrinol"},{"key":"key\n\t\t\t\t2019041113384404900_B41","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1365-2265.1999.00827.x","article-title":"Extrusion of testosterone pellets: a randomized controlled clinical study","volume":"51","author":"Kelleher","year":"1999","journal-title":"Clin Endocrinol"},{"key":"key\n\t\t\t\t2019041113384404900_B42","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1530\/eje.0.1460513","article-title":"A randomised controlled clinical trial of antibiotic impregnation of testosterone pellet implants to reduce extrusion rate","volume":"146","author":"Kelleher","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113384404900_B43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0002-9610(27)90777-6","article-title":"Paraffinomas","volume":"2","author":"McWillams","year":"1927","journal-title":"Am J Surg"},{"key":"key\n\t\t\t\t2019041113384404900_B44","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1136\/bmj.2.4955.1536","article-title":"Simulation of cancer by oil granulomas of therapeutic origin","volume":"2","author":"Symmers","year":"1955","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041113384404900_B45","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/00000433-199703000-00019","article-title":"Disseminated lipogranulomas and sudden death from self-administered mineral oil injection","volume":"18","author":"Rollins","year":"1997","journal-title":"Am J Forensic Med Pathol"},{"key":"key\n\t\t\t\t2019041113384404900_B46","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0190-9622(00)90144-0","article-title":"Subcutaneous oleomas induced by self-injection of sesame seed oil for muscle augmentation","volume":"42","author":"Darsow","year":"2000","journal-title":"J Am Acad Dermatol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/7\/2592\/17638428\/jcem2592.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T06:27:56Z","timestamp":1746167276000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/7\/2592\/2538164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2014-1243","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]}}}