{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:59:23Z","timestamp":1770440363612,"version":"3.49.0"},"reference-count":26,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"DOI":"10.1210\/jc.2014-1278","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T15:17:23Z","timestamp":1400512643000},"page":"2986-2994","source":"Crossref","is-referenced-by-count":63,"title":["Utility of Serum Procalcitonin for Screening and Risk Stratification of Medullary Thyroid Cancer"],"prefix":"10.1210","volume":"99","author":[{"given":"Andreas","family":"Machens","sequence":"first","affiliation":[{"name":"Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle-Wittenberg, D-06097 Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle-Wittenberg, D-06097 Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Dralle","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle-Wittenberg, D-06097 Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113415593700_B1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/thy.2012.0361","article-title":"Measurement of calcitonin and calcitonin gene-related peptide mRNA refines the management of patients with medullary thyroid cancer and may replace calcitonin-stimulation tests","volume":"23","author":"Camacho","year":"2013","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t2019041113415593700_B2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1089\/thy.2012.0236","article-title":"Prevalence and clinical spectrum of nonsecretory medullary thyroid carcinoma in a series of 839 patients with sporadic medullary thyroid carcinoma","volume":"23","author":"Frank-Raue","year":"2013","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t2019041113415593700_B3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1056\/NEJM196808082790602","article-title":"Medullary carcinoma of the thyroid gland. Studies of thyrocalcitonin in plasma and tumor extracts","volume":"279","author":"Tashjian","year":"1968","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113415593700_B4","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1210\/jc.2009-2368","article-title":"Biomarker-based risk stratification for previously untreated medullary thyroid cancer","volume":"95","author":"Machens","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113415593700_B5","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.surg.2011.09.043","article-title":"Preoperative basal calcitonin and tumor stage correlate with postoperative calcitonin normalization in patients undergoing initial surgical management of medullary thyroid carcinoma","volume":"150","author":"Yip","year":"2011","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041113415593700_B6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/SLA.0b013e318268301d","article-title":"Prognostic impact of N staging in 715 medullary thyroid cancer patients: proposal for a revised staging system","volume":"257","author":"Machens","year":"2013","journal-title":"Ann Surg"},{"key":"key\n\t\t\t\t2019041113415593700_B7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/SLA.0b013e31826bc239","article-title":"Benefit-risk balance of reoperation for persistent medullary thyroid cancer","volume":"257","author":"Machens","year":"2013","journal-title":"Ann Surg"},{"key":"key\n\t\t\t\t2019041113415593700_B8","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jc.2008-1862","article-title":"Procalcitonin: a marker for the diagnosis and follow-up of patients with medullary thyroid carcinoma","volume":"94","author":"Algeciras-Schimnich","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113415593700_B9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1373\/clinchem.2010.151688","article-title":"Basal and stimulated calcitonin and procalcitonin by various assays in patients with and without medullary thyroid cancer","volume":"57","author":"Kratzsch","year":"2011","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113415593700_B10","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1210\/jc.2004-1836","article-title":"Prospects of remission in medullary thyroid carcinoma according to basal calcitonin level","volume":"90","author":"Machens","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113415593700_B11","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1515\/CCLM.2007.124","article-title":"Measurement of calcitonin by immunoassay analyzers","volume":"45","author":"Bieglmayer","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"key\n\t\t\t\t2019041113415593700_B12","first-page":"267","article-title":"Screening for medullary thyroid carcinoma: experience with different immunoassays for human calcitonin","volume":"114","author":"Bieglmayer","year":"2002","journal-title":"Wien Klin Wochenschr"},{"key":"key\n\t\t\t\t2019041113415593700_B13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF02473391","article-title":"Compartment-oriented microdissection of regional lymph nodes in medullary thyroid carcinoma","volume":"24","author":"Dralle","year":"1994","journal-title":"Surg Today"},{"key":"key\n\t\t\t\t2019041113415593700_B14","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1046\/j.1365-2168.2002.02160.x","article-title":"Lymph node dissection and medullary thyroid carcinoma","volume":"89","author":"Dralle","year":"2002","journal-title":"Br J Surg"},{"key":"key\n\t\t\t\t2019041113415593700_B15","article-title":"Malignant thyroid tumors [in German]","volume-title":"Abbreviated Interdisciplinary Guidelines 2006. Recommendations for Diagnosis and Therapy of Malignant Diseases","author":"Dralle","year":"2006"},{"key":"key\n\t\t\t\t2019041113415593700_B16","article-title":"Histological typing of thyroid tumours","volume-title":"International Histological Classification of Tumours","author":"Hedinger","year":"1988","edition":"2nd ed"},{"key":"key\n\t\t\t\t2019041113415593700_B17","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Endocrine Organs","author":"DeLellis","year":"2004"},{"key":"key\n\t\t\t\t2019041113415593700_B18","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1515\/cclm-2012-0610","article-title":"Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules","volume":"51","author":"Giovanella","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"key\n\t\t\t\t2019041113415593700_B19","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1365-2265.2009.03733.x","article-title":"Elevated calcitonin and procalcitonin levels in nonmedullary benign and malignant thyroid nodules","volume":"72","author":"Giovanella","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113415593700_B20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/cncr.24738","article-title":"Procalcitonin levels predict clinical course and progression-free survival in patients with medullary thyroid cancer","volume":"116","author":"Walter","year":"2010","journal-title":"Cancer"},{"key":"key\n\t\t\t\t2019041113415593700_B21","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1677\/ERC-09-0136","article-title":"Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer","volume":"16","author":"Machens","year":"2009","journal-title":"Endocr Relat Cancer"},{"key":"key\n\t\t\t\t2019041113415593700_B22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1089\/105072503768499716","article-title":"Calcitonin precursor levels in human medullary thyroid carcinoma","volume":"8","author":"Bihan","year":"2003","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t2019041113415593700_B23","first-page":"169","article-title":"Calcitonin and procalcitonin in patients with medullary thyroid cancer or bacterial infection","volume":"21","author":"Kaczka","year":"2012","journal-title":"Adv Clin Exp Med"},{"key":"key\n\t\t\t\t2019041113415593700_B24","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/jnci\/dji237","article-title":"Reporting recommendations for tumor marker prognostic studies (REMARK)","volume":"97","author":"McShane","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t2019041113415593700_B25","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1200\/JCO.2009.22.3701","article-title":"Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges","volume":"27","author":"Mandrekar","year":"2009","journal-title":"J Clin Oncol"},{"key":"key\n\t\t\t\t2019041113415593700_B26","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1089\/thy.2013.0664","article-title":"Medullary thyroid carcinoma preferentially secreting procalcitonin","volume":"24","author":"Bugalho","year":"2014","journal-title":"Thyroid"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/8\/2986\/9050635\/jcem2986.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T19:30:39Z","timestamp":1716751839000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/8\/2986\/2538462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,1]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2014-1278","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,1]]}}}