{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T20:55:28Z","timestamp":1761252928074},"reference-count":19,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context:<\/jats:title><jats:p>We previously reported on four patients treated with PTH(1\u201384) who recovered from postoperative hypoparathyroidism many years after onset. Because vascular endothelial growth factor (VEGF) has been shown to be necessary for the induction of PTH-mediated angiogenesis, we postulated a possible role for VEGF in the recovery of parathyroid function in these subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Our objective was to measure VEGF levels in subjects with hypoparathyroidism who regained parathyroid gland function and matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Design:<\/jats:title><jats:p>Subjects with hypoparathyroidism who regained parathyroid gland function were each matched to two hypoparathyroid controls by postoperative etiology, age (within 5 y), menopausal status, and duration of hypoparathyroidism. We measured serum VEGF levels at baseline and through 48 months of PTH(1\u201384) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>VEGF levels increased after the initiation of PTH(1\u201384) therapy for the entire cohort, from 309.7 \u00b1 162 pg\/ml at baseline to 380.2 \u00b1 178 pg\/ml at 12 months (P = .03). Levels trended downward thereafter. There were no significant differences in VEGF levels between the subjects with recovery of parathyroid function and the matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>PTH(1\u201384) alters serum VEGF levels in subjects with hypoparathyroidism. Additional investigation is necessary to understand the mechanisms by which some subjects with postoperative hypoparathyroidism recover parathyroid gland function.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2014-1500","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T13:59:09Z","timestamp":1408456749000},"page":"E2025-E2028","source":"Crossref","is-referenced-by-count":8,"title":["Parathyroid Hormone 1\u201384 Alters Circulating Vascular Endothelial Growth Factor Levels in Hypoparathyroidism"],"prefix":"10.1210","volume":"99","author":[{"given":"Natalie E.","family":"Cusano","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mishaela R.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, College of 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