{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:41:38Z","timestamp":1790264498147,"version":"4.1.0"},"reference-count":30,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction:<\/jats:title>\n                  <jats:p>Recent studies show an association between hyponatremia and osteoporosis. We have previously reported a case of severe male osteoporosis due to chronic syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Here, we provide a follow-up on this case after cure of the condition that further supports the causal relationship.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>The Case:<\/jats:title>\n                  <jats:p>A 38-year-old man had been diagnosed with severe osteoporosis most likely due to chronic SIADH. The SIADH was believed to be idiopathic. A magnetic resonance imaging scan, however, revealed a tumor in the sinus, and biopsies showed an esthesioneuroblastoma, immunohistochemically positive for antidiuretic hormone (ADH). After the tumor was removed, ADH and sodium levels normalized. A dual-energy x-ray absorptiometry scan performed 7 months after the patient's last surgery showed a significant spontaneous improvement in bone mineral density in the lumbar vertebrae.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>This case provides evidence for a causal relationship between SIADH and chronic hyponatremia and impaired bone metabolism that can lead to severe secondary osteoporosis. The effect on bone metabolism is at least partially reversible.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2014-1572","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T17:12:13Z","timestamp":1403889133000},"page":"3527-3530","source":"Crossref","is-referenced-by-count":41,"title":["Recovery From SIADH-Associated Osteoporosis: A Case Report"],"prefix":"10.1210","volume":"99","author":[{"given":"Anne-Sophie","family":"Sejling","sequence":"first","affiliation":[{"name":"Department of Cardiology, Nephrology, and Endocrinology (A.-S.S., A.-L.T., U.P.-B., P.E.), Nordsj\u00e6llands Hospital, DK-3400 Hiller\u00f8d, Denmark"},{"name":"Faculty of Health Sciences (A.-S.S.), University of Southern Denmark, DK-5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Luise","family":"Thorsteinsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nephrology, and Endocrinology (A.-S.S., A.-L.T., U.P.-B., P.E.), Nordsj\u00e6llands Hospital, DK-3400 Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Pedersen-Bjergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nephrology, and Endocrinology (A.-S.S., A.-L.T., U.P.-B., P.E.), Nordsj\u00e6llands Hospital, DK-3400 Hiller\u00f8d, Denmark"},{"name":"Faculty of Health Sciences (U.P.-B., P.E.), University of Copenhagen, DK-2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Eiken","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nephrology, and Endocrinology (A.-S.S., A.-L.T., U.P.-B., P.E.), Nordsj\u00e6llands Hospital, DK-3400 Hiller\u00f8d, Denmark"},{"name":"Faculty of Health Sciences (U.P.-B., P.E.), University of Copenhagen, DK-2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071616350444800_B1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0002-9343(57)90224-3","article-title":"A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone","volume":"23","author":"Schwartz","year":"1957","journal-title":"Am J Med"},{"key":"2020071616350444800_B2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/2042018812437561","article-title":"Clinical management of SIADH","volume":"3","author":"Gross","year":"2012","journal-title":"Ther Adv Endocrinol Metab"},{"key":"2020071616350444800_B3","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1056\/NEJMcp066837","article-title":"Clinical practice. 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