{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:41:42Z","timestamp":1770486102971,"version":"3.49.0"},"reference-count":24,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Maternal hypothyroidism in early pregnancy is associated with adverse outcomes, but not consistently across studies. First trimester screening for chromosomal anomalies is routine in many centers and provides an opportunity to test thyroid function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To determine if thyroid function tests performed with first trimester screening predicts adverse pregnancy outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, Participants and Setting:<\/jats:title>\n                  <jats:p>A cohort study of 2411 women in Western Australia with singleton pregnancies attending first trimester screening between 9 and 14 weeks gestation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcome Measures:<\/jats:title>\n                  <jats:p>We evaluated the association between TSH, free T4, free T3, thyroid antibodies, free beta human chorionic gonadotrophin (\u03b2-hCG) and pregnancy associated plasma protein A (PAPP-A) with a composite of adverse pregnancy events as the primary outcome. Secondary outcomes included placenta previa, placental abruption, pre-eclampsia, pregnancy loss after 20 weeks gestation, threatened preterm labor, preterm birth, small size for gestational age, neonatal death, and birth defects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>TSH exceeded the 97.5th percentile for the first trimester (2.15 mU\/L) in 133 (5.5%) women, including 22 (1%) with TSH above the nonpregnant reference range (4 mU\/L) and 5 (0.2%) above 10 mU\/L. Adverse outcomes occurred in 327 women (15%). TSH and free T4 did not differ significantly between women with or without adverse pregnancy events. On the multivariate analysis, neither maternal TSH &amp;gt;2.15 mU\/L nor TSH as a continuous variable predicted primary or secondary outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Testing maternal TSH as part of first trimester screening does not predict adverse pregnancy outcomes. This may be because in the community setting, mainly mild abnormalities in thyroid function are detected.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2014-1918","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T15:23:15Z","timestamp":1410880995000},"page":"E2668-E2672","source":"Crossref","is-referenced-by-count":30,"title":["Does the Thyroid-Stimulating Hormone Measured Concurrently With First Trimester Biochemical Screening Tests Predict Adverse Pregnancy Outcomes Occurring After 20 Weeks Gestation?"],"prefix":"10.1210","volume":"99","author":[{"given":"Gregory S. Y.","family":"Ong","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes (G.S.Y.O., S.J.B., E.M.L., J.P.W.), Nedlands 6009 Australia"},{"name":"Department of General Medicine (G.S.Y.O.), Sir Charles Gairdner Hospital, Nedlands 6009 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narelle C.","family":"Hadlow","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry (N.C.H., E.M.L.), PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands 6009 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes (G.S.Y.O., S.J.B., E.M.L., J.P.W.), Nedlands 6009 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ee Mun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes (G.S.Y.O., S.J.B., E.M.L., J.P.W.), Nedlands 6009 Australia"},{"name":"Department of Clinical Biochemistry (N.C.H., E.M.L.), PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands 6009 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes (G.S.Y.O., S.J.B., E.M.L., J.P.W.), Nedlands 6009 Australia"},{"name":"School of Medicine and Pharmacology (J.P.W.), The University of Western Australia, Crawley 6009 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071614595284100_B1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/cen.12232","article-title":"Screening for overt thyroid disease in early pregnancy may be preferable to searching for small aberrations in thyroid function tests","volume":"79","author":"Laurberg","year":"2013","journal-title":"Clin Endocrinol"},{"key":"2020071614595284100_B2","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1210\/jc.2009-2009","article-title":"Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy","volume":"95","author":"Negro","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614595284100_B3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJMoa1106104","article-title":"Antenatal thyroid screening and childhood cognitive function","volume":"366","author":"Lazarus","year":"2012","journal-title":"N Engl J Med"},{"key":"2020071614595284100_B4","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1210\/jc.2011-2803","article-title":"Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline","volume":"97","author":"De Groot","year":"2012","journal-title":"J Clin Endocrinol 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outcome","volume":"112","author":"Cleary-Goldman","year":"2008","journal-title":"Obstet Gynecol"},{"key":"2020071614595284100_B8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/01.AOG.0000152345.99421.22","article-title":"Subclinical hypothyroidism and pregnancy outcomes","volume":"105","author":"Casey","year":"2005","journal-title":"Obstet Gynecol"},{"key":"2020071614595284100_B9","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1210\/jc.2012-1193","article-title":"Association and predictive accuracy of high TSH serum levels in first trimester and adverse pregnancy outcomes","volume":"97","author":"Schneuer","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614595284100_B10","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1210\/jc.2012-2540","article-title":"Thyroid dysfunction and autoantibodies in early pregnancy are associated with increased risk of gestational diabetes and adverse birth outcomes","volume":"97","author":"Karakosta","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614595284100_B11","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1210\/jc.2008-1520","article-title":"Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study","volume":"94","author":"M\u00e4nnist\u00f6","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614595284100_B12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/pd.1898","article-title":"Use of the combined first-trimester screen result and low PAPP-A to predict risk of adverse fetal outcomes","volume":"28","author":"Barrett","year":"2008","journal-title":"Prenat Diagn"},{"key":"2020071614595284100_B13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.5694\/j.1326-5377.2008.tb02015.x","article-title":"Assessment of thyroid function during pregnancy: first-trimester (weeks 9\u201313) reference intervals derived from Western Australian women","volume":"189","author":"Gilbert","year":"2008","journal-title":"Med J Aust"},{"key":"2020071614595284100_B14","unstructured":"Le\n              M\n            , TranB. Perinatal Statistics in Western Australia 2008: Twenty-sixth Annual Report of the Western Australian Midwives' Notification System. http:\/\/www.health.wa.gov.au\/publications\/documents\/perinatal\/PerinatalStatisticsWA2008.pdf Government of Western Australia, Department of Health. 2008. Accessed March 29, 2014"},{"key":"2020071614595284100_B15","unstructured":"Bower\n              C\n            , RudyE, CallaghanA, QuickJ. 2010 Report of the Birth Defects Registry of Western Australia 1980\u20132009. http:\/\/www.kemh.health.wa.gov.au\/services\/register_developmental_anomalies\/documents\/2010_Annual_Report.pdf King Edward Memorial Hospital. 2010. Accessed March 29, 2014"},{"key":"2020071614595284100_B16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.5694\/j.1326-5377.1999.tb127678.x","article-title":"Australian national birthweight percentiles by gestational age","volume":"170","author":"Roberts","year":"1999","journal-title":"Med J Aust"},{"key":"2020071614595284100_B17","doi-asserted-by":"crossref","first-page":"E44","DOI":"10.1210\/jc.2010-0340","article-title":"Increased pregnancy loss rate in thyroid antibody negative women with TSH levels between 2.5 and 5.0 in the first trimester of pregnancy","volume":"95","author":"Negro","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614595284100_B18","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1530\/EJE-08-0953","article-title":"Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death","volume":"160","author":"Benhadi","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"2020071614595284100_B19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00404-009-1105-1","article-title":"Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome","volume":"281","author":"Sahu","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"2020071614595284100_B20","first-page":"349","article-title":"Perinatal Outcome in Hypothyroid Pregnancies","volume":"81","author":"Leung","year":"1993","journal-title":"Obstet Gynecol"},{"key":"2020071614595284100_B21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/105072502753451986","article-title":"Overt and subclinical hypothyroidism complicating pregnancy","volume":"12","author":"Abalovich","year":"2002","journal-title":"Thyroid"},{"key":"2020071614595284100_B22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/jms.7.3.127","article-title":"Maternal thyroid deficiency and pregnancy complications: implications for population screening","volume":"7","author":"Allan","year":"2000","journal-title":"J Med Screen"},{"key":"2020071614595284100_B23","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1210\/jc.2012-4233","article-title":"Thyroid Diseases and Adverse Pregnancy Outcomes in a Contemporary US Cohort","volume":"98","author":"M\u00e4nnist\u00f6","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614595284100_B24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1530\/EJE-13-0228","article-title":"Pregnancy outcomes in women with severe hypothyroidism","volume":"169","author":"Hirsch","year":"2013","journal-title":"Eur J Endocrinol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/12\/E2668\/9083484\/jcem2668.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/12\/E2668\/9083484\/jcem2668.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T02:27:51Z","timestamp":1594952871000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/12\/E2668\/2833421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,1]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2014-1918","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,1]]}}}