{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:38:55Z","timestamp":1792330735996,"version":"4.4.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"DOI":"10.1210\/jc.2014-1976","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T17:01:30Z","timestamp":1403024490000},"page":"E1701-E1707","source":"Crossref","is-referenced-by-count":23,"title":["A Randomized Controlled Trial of the Effects of Pioglitazone Treatment on Sympathetic Nervous System Activity and Cardiovascular Function in Obese Subjects With Metabolic Syndrome"],"prefix":"10.1210","volume":"99","author":[{"given":"Nora E.","family":"Straznicky","sequence":"first","affiliation":[{"name":"Laboratories of Human Neurotransmitters (N.E.S., M.T.G., C.L.S., N.E., G.W.L., K.R., J.B.D., E.A.L.), Melbourne, Victoria 8008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariee T.","family":"Grima","sequence":"additional","affiliation":[{"name":"Laboratories of Human Neurotransmitters (N.E.S., M.T.G., C.L.S., N.E., G.W.L., K.R., J.B.D., E.A.L.), Melbourne, Victoria 8008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina I.","family":"Sari","sequence":"additional","affiliation":[{"name":"Laboratories of Human Neurotransmitters (N.E.S., M.T.G., C.L.S., N.E., G.W.L., K.R., J.B.D., E.A.L.), Melbourne, Victoria 8008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Eikelis","sequence":"additional","affiliation":[{"name":"Laboratories of Human Neurotransmitters (N.E.S., M.T.G., C.L.S., N.E., G.W.L., K.R., J.B.D., E.A.L.), Melbourne, Victoria 8008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin W.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Laboratories of Human Neurotransmitters (N.E.S., M.T.G., C.L.S., N.E., G.W.L., K.R., J.B.D., E.A.L.), Melbourne, Victoria 8008, Australia"},{"name":"Faculty of Medicine, Nursing, and Health Sciences (G.W.L., M.P.S.), Melbourne, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Nestel","sequence":"additional","affiliation":[{"name":"Cardiovascular Nutrition (P.J.N.), Melbourne, Victoria 8008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Karapanagiotidis","sequence":"additional","affiliation":[{"name":"Alfred Baker Medical Unit (S.K., C.W.), Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiew","family":"Wong","sequence":"additional","affiliation":[{"name":"Alfred Baker Medical Unit (S.K., C.W.), Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Richards","sequence":"additional","affiliation":[{"name":"Laboratories of Human Neurotransmitters (N.E.S., M.T.G., C.L.S., N.E., G.W.L., K.R., J.B.D., E.A.L.), Melbourne, Victoria 8008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Marusic","sequence":"additional","affiliation":[{"name":"Neurovascular Hypertension and Kidney Disease (P.M., M.P.S.), Melbourne, Victoria 8008, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Laboratories of Human Neurotransmitters (N.E.S., M.T.G., C.L.S., N.E., G.W.L., K.R., J.B.D., E.A.L.), Melbourne, Victoria 8008, Australia"},{"name":"Primary Health Care (J.B.D.), Monash University, Melbourne, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus P.","family":"Schlaich","sequence":"additional","affiliation":[{"name":"Neurovascular Hypertension and Kidney Disease (P.M., M.P.S.), Melbourne, Victoria 8008, Australia"},{"name":"Faculty of Medicine, Nursing, and Health Sciences (G.W.L., M.P.S.), Melbourne, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Laboratories of Human Neurotransmitters (N.E.S., M.T.G., C.L.S., N.E., G.W.L., K.R., J.B.D., E.A.L.), Melbourne, Victoria 8008, Australia"},{"name":"the Departments of Physiology (E.A.L.), Melbourne, Victoria 3800, Australia"},{"name":"the Department of Physiology (E.A.L.), University of Melbourne, Melbourne 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113404326000_B1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00004872-199603000-00005","article-title":"Influence of insulin, sympathetic nervous system activity, and obesity on blood pressure: the Normative Aging Study","volume":"14","author":"Ward","year":"1993","journal-title":"J Hypertens"},{"key":"key\n\t\t\t\t2019041113404326000_B2","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.2337\/db12-0138","article-title":"Neuroadrenergic dysfunction along the diabetes continuum. A comparative study in obese metabolic syndrome subjects","volume":"61","author":"Straznicky","year":"2012","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113404326000_B3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/01.HYP.21.5.618","article-title":"Reflex sympathetic activation induces acute insulin resistance in the human forearm","volume":"21","author":"Jamerson","year":"1993","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t2019041113404326000_B4","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1007\/s00125-006-0399-9","article-title":"Sympathetic nerve hyperactivity in non-diabetic offspring of patients with type 2 diabetes mellitus","volume":"49","author":"Huggett","year":"2006","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113404326000_B5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1475-2840-4-15","article-title":"Circadian rhythm of autonomic activity in non-diabetic offspring of type 2 diabetic patients","volume":"4","author":"Fiorentini","year":"2005","journal-title":"Cardiovasc Diabetol"},{"key":"key\n\t\t\t\t2019041113404326000_B6","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s11906-008-0083-1","article-title":"Mediators of sympathetic activation in metabolic syndrome obesity","volume":"10","author":"Straznicky","year":"2008","journal-title":"Curr Hypertens Rep"},{"key":"key\n\t\t\t\t2019041113404326000_B7","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/BF00399935","article-title":"The sympathetic response to euglycemic hyperinsulinemia. Evidence from microelectrode nerve recordings in healthy subjects","volume":"35","author":"Berne","year":"1992","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113404326000_B8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0006-8993(93)90258-O","article-title":"Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus","volume":"602","author":"Figlewicz","year":"1993","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t2019041113404326000_B9","doi-asserted-by":"crossref","first-page":"11305","DOI":"10.1523\/JNEUROSCI.0126-10.2010","article-title":"Insulin reveals Akt signalling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis","volume":"30","author":"Robertson","year":"2010","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t2019041113404326000_B10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1475-2840-10-75","article-title":"Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia","volume":"10","author":"Thackeray","year":"2011","journal-title":"Cardiovasc Diabetol"},{"key":"key\n\t\t\t\t2019041113404326000_B11","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.CIR.0000081775.72651.B6","article-title":"Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy","volume":"108","author":"Schlaich","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113404326000_B12","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.autneu.2010.05.003","article-title":"Effect of pioglitazone on muscle sympathetic nerve activity in type 2 diabetes mellitus with \u03b1-glucosidase inhibitor","volume":"158","author":"Kobayashi","year":"2010","journal-title":"Auton Neurosci"},{"key":"key\n\t\t\t\t2019041113404326000_B13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/FJC.0b013e31824f91a7","article-title":"Effect of pioglitazone on arterial baroreflex sensitivity and sympathetic nerve activity in patients with acute myocardial infarction and type 2 diabetes mellitus","volume":"59","author":"Yokoe","year":"2012","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t2019041113404326000_B14","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s10286-005-0292-5","article-title":"Sympathetic nerve function. Assessment by radioisotope dilution analysis","volume":"15","author":"Eisenhofer","year":"2005","journal-title":"Clin Auton Res"},{"key":"key\n\t\t\t\t2019041113404326000_B15","first-page":"E505","article-title":"Neuronal uptake, metabolism, and release of tritium-labeled norepinephrine during assessment of its plasma kinetics","volume":"261","author":"Eisenhofer","year":"1991","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113404326000_B16","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1210\/jc.2003-031526","article-title":"Effects of the peroxisomal proliferator-activated receptor-\u03b3 agonist pioglitazone on renal and hormonal responses to salt in healthy men","volume":"89","author":"Zanchi","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113404326000_B17","first-page":"401","article-title":"Pioglitazone improves ventricular diastolic function in patients with diabetes mellitus: a tissue Doppler study","volume":"65","author":"Ordu","year":"2010","journal-title":"Acta Cardiol"},{"key":"key\n\t\t\t\t2019041113404326000_B18","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1097\/00004872-200409000-00021","article-title":"Improvement of insulin resistance by troglitazone ameliorates cardiac sympathetic nervous dysfunction in patients with essential hypertension","volume":"22","author":"Watanabe","year":"2004","journal-title":"J Hypertens"},{"key":"key\n\t\t\t\t2019041113404326000_B19","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00259-007-0421-6","article-title":"Abdominal visceral fat accumulation is associated with the results of 123I-metaiodobenzylguanidine myocardial scintigraphy in type 2 diabetic patients","volume":"34","author":"Anan","year":"2007","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"key\n\t\t\t\t2019041113404326000_B20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/01.CIR.78.1.41","article-title":"In vivo measurement of neuronal uptake of norepinephrine in the human heart","volume":"78","author":"Goldstein","year":"1988","journal-title":"Circulation"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/99\/9\/E1701\/9046470\/jcem1701.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T16:19:42Z","timestamp":1565540382000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/99\/9\/E1701\/2537524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,1]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2014-1976","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,1]]}}}