{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:20:06Z","timestamp":1775643606728,"version":"3.50.1"},"reference-count":33,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>To the best of our knowledge, no study has examined the effects of vitamin D-calcium cosupplementation on inflammatory biomarkers and adipocytokines in vitamin D-insufficient type 2 diabetics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>This study was performed to assess the effects of vitamin D and calcium supplementation on inflammatory biomarkers and adipocytokines in vitamin D-insufficient people with type 2 diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Totally, 118 diabetic patients were enrolled in this randomized, placebo-controlled clinical trial. After matching for age, sex, body mass index, type and dose of hypoglycemic agents, and duration of diabetes, subjects were randomly assigned into 4 groups receiving the following: 1) 50000 IU\/wk vitamin D + calcium placebo; 2) 1000 mg\/d calcium + vitamin D placebo; 3) 50 000 IU\/wk vitamin D + 1000 mg\/d calcium; or 4) vitamin D placebo + calcium placebo for 8 weeks. Blood sampling was done for the quantification of inflammatory biomarkers and adipocytokines at the study baseline and after 8 weeks of intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Calcium (changes from baseline: \u221275\u00b119 ng\/ml, P = .01) and vitamin D alone (\u221256 \u00b1 19 ng\/mL, P = .01) and joint calcium-vitamin D supplementation (\u221292 \u00b1 19 ng\/mL, P = .01) resulted in a significant reduction in serum leptin levels compared with placebo (\u22129 \u00b1 18 ng\/mL). This was also the case for serum IL-6, such that calcium (\u22122 \u00b1 1 pg\/mL, P &amp;lt; .001) and vitamin D alone (\u22124 \u00b1 1 pg\/mL, P &amp;lt; .001) and their combination (\u22124 \u00b1 1 pg\/mL, P &amp;lt; .001) led to significant reductions compared with placebo (3 \u00b1 1 pg\/mL). After adjustment for potential confounders, individuals in the calcium (\u22123.1 \u00b1 1.3, P &amp;lt; .05), vitamin D (\u22123.1 \u00b1 1.3, P &amp;lt; .05), and joint calcium-vitamin D groups (\u22123.4 \u00b1 1.3, P &amp;lt; .05) had greater reductions in serum TNF-\u03b1 concentrations compared with placebo (0.1 \u00b1 1.2). Individuals who received joint calcium-vitamin D supplements tended to have a decrease in serum high-sensitivity C-reactive protein levels compared with placebo after controlling for baseline levels (\u22121.14 \u00b1 0.25 vs 0.02 \u00b1 0.24 ng\/mL, P = .09).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-\u03b1 concentrations in vitamin D-insufficient people with type 2 diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2014-1977","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T22:49:33Z","timestamp":1417819773000},"page":"E2485-E2493","source":"Crossref","is-referenced-by-count":48,"title":["Calcium-Vitamin D Cosupplementation Influences Circulating Inflammatory Biomarkers and Adipocytokines in Vitamin D-Insufficient Diabetics: A Randomized Controlled Clinical Trial"],"prefix":"10.1210","volume":"99","author":[{"given":"Maryam","family":"Tabesh","sequence":"first","affiliation":[{"name":"Food Security Research Center (Marj.T., L.A., Mary.T., A.E.), Isfahan 81745-151, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Azadbakht","sequence":"additional","affiliation":[{"name":"Food Security Research Center (Marj.T., L.A., Mary.T., A.E.), Isfahan 81745-151, Iran"},{"name":"Department of Community Nutrition (Marj.T., L.A., A.E.), Isfahan 81745-151, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Faghihimani","sequence":"additional","affiliation":[{"name":"School of Nutrition and Food Science, and Isfahan Endocrine and Metabolism Research Center (E.F.) 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