{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:18:49Z","timestamp":1780435129987,"version":"3.54.1"},"reference-count":42,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"Abstract<\/jats:title>\n \n Context:<\/jats:title>\n Bone loss is a constant finding in patients with spinal cord injury (SCI).<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n We sought to evaluate potential modifiable factors that could lead to bone loss in complete motor paraplegia by examining gonadal axis hormones, vitamin D status, and bone markers.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n This is a cross sectional.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n It includes SCI Outpatient.<\/jats:p>\n <\/jats:sec>\n \n Patients and other Participants:<\/jats:title>\n Twenty-nine chronic male patients with SCI were compared with 17 age-matched, able-bodied men.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measure:<\/jats:title>\n The bone mineral density (BMD) of lower limbs and lumbar spine were measured using dual x-ray absorptiometry. Parathormone, 25-hydroxyvitamin D [25(OH)D], collagen type I C-terminal telopeptide (CTX), and sexual hormone were measured.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Patients with SCI had lower BMD at the inferior limbs sites. CTX showed an inverse relationship with the time since injury. Patients had lower free T levels (SCI, 12.00 \u00b1 2.91 vs controls, 19.51 \u00b1 5.72; P \u2264 .001), and the majority (72%) had normal\/low levels of gonadotropins. Low T, however, was not related to low bone mass in patients with SCI. In the controls, the 25(OH)D level was positively correlated with the T and with the lumbar spine BMD, but these correlations were not observed in the SCI.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Impairment of testicular function after SCI was indicated by the low levels of T and the loss of correlation between T and 25(OH)D levels; this correlation was present in the able-bodied controls. Inappropriate levels of gonadotropins were identified in most patients, featuring a hypogonadotropic hypogonadism and suggesting a disruption of the pituitary-gonadal axis. T concentrations might not be an effective target for bone loss therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/jc.2014-2165","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T17:16:13Z","timestamp":1410801373000},"page":"4649-4655","source":"Crossref","is-referenced-by-count":24,"title":["Bone Mass and Hormone Analysis in Patients With Spinal Cord Injury:\n Evidence for a Gonadal Axis Disruption"],"prefix":"10.1210","volume":"99","author":[{"given":"Alexandra Passos","family":"Gaspar","sequence":"first","affiliation":[{"name":"Division of Endocrinology (A.P.G., C.M.A.B., M.L.-C.), Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04021-001, Brazil; and Associa\u00e7\u00e3o de Assist\u00eancia \u00e0 Crian\u00e7a Deficiente (A.P.G.), S\u00e3o Paulo 04027-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M. A.","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (A.P.G., C.M.A.B., M.L.-C.), Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04021-001, Brazil; and Associa\u00e7\u00e3o de Assist\u00eancia \u00e0 Crian\u00e7a Deficiente (A.P.G.), S\u00e3o Paulo 04027-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marise","family":"Lazaretti-Castro","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (A.P.G., C.M.A.B., M.L.-C.), Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04021-001, Brazil; and Associa\u00e7\u00e3o de Assist\u00eancia \u00e0 Crian\u00e7a Deficiente (A.P.G.), S\u00e3o Paulo 04027-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"2020071615003381600_B1","doi-asserted-by":"crossref","first-page":"982","DOI":"10.2106\/00004623-194830040-00020","article-title":"Bone 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