{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:25:12Z","timestamp":1789208712816,"version":"build-2803163510"},"reference-count":36,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"\n Background:<\/jats:title>\n Low total T is associated with an increased risk of atherosclerotic complications. However, the magnitude of this association in middle-aged patients with type 2 diabetes (T2D) has not been determined.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n This cross-sectional study evaluated atherosclerotic disease markers in T2D patients with normal and low plasma total T. A total of 115 male patients, aged younger than 70 years, without a history of cardiovascular events, and with normal [\u22653.5 ng\/mL (\u226512.1 nmol\/L), n = 79] or low [&lt; 3.5 ng\/mL (\u226412.1 nmol\/L), n = 36] total T underwent the measurement of highly sensitive C-reactive protein, carotid artery carotid intima-media thickness (IMT), and atherosclerotic plaque by high-resolution B-mode ultrasound and to asses endothelial function by brachial artery flow-mediated dilation.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Carotid IMT was negatively correlated with total T concentration (r = \u22120.39, P &lt; .0001). Compared with subjects with normal T, a higher proportion of patients with low total T had carotid IMT of 0.1 cm or greater [80% vs 39%, odds ratio (OR) 6.41; 95% CI 2.5\u201316.4, P &lt; .0001], atherosclerotic plaques (68.5% vs 44.8%, OR 2.60, 95% CI 1.12\u20136.03, P &lt; .0001); endothelial dysfunction (80.5% vs 42.3%, OR 5.77, 95% CI 2.77\u201314.77, P &lt; .003), and higher highly sensitive C-reactive protein levels (2.74 \u00b1 5.82 vs 0.89 \u00b1 0.88 mg\/L, P &lt; .0001). Similar results were found when free T was considered. Multiple logistic regression analyses adjusted for age, diabetes mellitus duration, hemoglobin A1c, lipids, treatment effect, and body mass index reported that a low total T level was independently associated with greater IMT [OR 8.43 (95% CI 2.5\u201325.8)] and endothelial dysfunction [OR 5.21 (95% CI 1.73\u201315.66)] but not with the presence of atherosclerotic plaques (OR 1.77, 95% CI 0.66\u20134.74).<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Low T is associated with more advanced atherosclerotic disease markers in middle-aged patients with T2D.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/jc.2014-2585","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T17:11:10Z","timestamp":1413479470000},"page":"4698-4703","source":"Crossref","is-referenced-by-count":41,"title":["Low Testosterone Concentration and Atherosclerotic Disease Markers in Male Patients With Type 2 Diabetes"],"prefix":"10.1210","volume":"99","author":[{"given":"Javier 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