{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:54:58Z","timestamp":1778615698708,"version":"3.51.4"},"reference-count":39,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context:<\/jats:title><jats:p>NACHT leucine-rich-repeat protein 5 (NALP5)\/maternal antigen that embryo requires (MATER) is an autoantigen in hypoparathyroidism associated with autoimmune polyendocrine syndrome type 1 (APS1) but is also expressed in the ovary. Mater is an autoantigen in experimental autoimmune oophoritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives:<\/jats:title><jats:p>The objectives of the study were to determine the frequency of NALP5\/MATER autoantibodies (NALP5\/MATER-Ab) in women with premature ovarian insufficiency (POI) and in patients with autoimmune Addison's disease (AAD) and to evaluate whether inhibin chains are a target for autoantibodies in POI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Autoantibodies against NALP5\/MATER and inhibin chains-\u03b1 and -\u03b2A were determined by radiobinding assays in 172 patients with AAD without clinical signs of gonadal insufficiency, 41 women with both AAD and autoimmune POI [steroidogenic cell autoimmune POI (SCA-POI)], 119 women with idiopathic POI, 19 patients with APS1, and 211 healthy control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>NALP5\/MATER-Ab were detected in 11 of 19 (58%) sera from APS1 patients, 12 of 172 (7%) AAD sera, 5 of 41 (12%) SCA-POI sera, 0 of 119 idiopathic POI sera and 1 of 211 healthy control sera (P &amp;lt; .001). None of 160 POI sera, including 41 sera from women with SCA-POI and 119 women with idiopathic POI, and none of 211 healthy control sera were positive for inhibin chain-\u03b1\/\u03b2A autoantibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>NALP5\/MATER-Ab are associated with hypoparathyroidism in APS1 but are present also in patients with AAD and in women with SCA-POI without hypoparathyroidism. Inhibin chains do not appear to be likely candidate targets of autoantibodies in human POI.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2014-3571","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T17:16:36Z","timestamp":1425402996000},"page":"1941-1948","source":"Crossref","is-referenced-by-count":26,"title":["Autoantibody Response Against NALP5\/MATER in Primary Ovarian Insufficiency and in Autoimmune Addison's Disease"],"prefix":"10.1210","volume":"100","author":[{"given":"Annalisa","family":"Brozzetti","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (A.B., S.M., V.M., A.F.), University of Perugia, 06126 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alimohammadi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences (M.A., O.K.), Science for Life Laboratory, Uppsala University, 750 03 Uppsala, Sweden"},{"name":"Centre of Molecular Medicine (M.A., A.H., O.K.), Department of Medicine (Solna), Karolinska Institutet, 171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.B., S.M., V.M., A.F.), University of Perugia, 06126 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Minarelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.B., S.M., V.M., A.F.), University of Perugia, 06126 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u212bsa","family":"Hallgren","sequence":"additional","affiliation":[{"name":"Centre of Molecular Medicine (M.A., A.H., O.K.), Department of Medicine (Solna), Karolinska Institutet, 171 76 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Giordano","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology, and Metabolism (R.G.), Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"De Bellis","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic and Respiratory Science (A.D.B.), Endocrinology Unit, Second University of Naples, 80132 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Perniola","sequence":"additional","affiliation":[{"name":"Department of Pediatrics-Neonatal Intensive Care (R.P.), V. 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