{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:50:16Z","timestamp":1789091416828,"version":"build-2803163510"},"reference-count":25,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:sec><jats:title>Context:<\/jats:title><jats:p>In primary aldosteronism (PA), adrenal vein sampling (AVS) distinguishes unilateral and bilateral disease by comparison of aldosterone\/cortisol (A\/F) ratios. There is controversy about the criteria for interpretation, however, and in particular it is not clear whether contralateral suppression (CS) (defined as A\/Fadrenal \u2264 A\/Fperipheral on the unaffected side) is important. We therefore performed a retrospective study to determine whether CS in surgically treated unilateral PA was associated with blood pressure (BP) and biochemical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting and Design:<\/jats:title><jats:p>Patients who underwent unilateral adrenalectomy for PA after successful AVS were included if the lateralization index (A\/Fdominant:A\/Fnondominant) was \u22652. Cases were reviewed at 6 to 24 months follow-up for outcomes with respect to the presence and degree of CS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Sixty-six of 80 patients had CS. Baseline characteristics were similar. At postoperative follow-up, those with CS had lower systolic BP (SBP) (128 mm Hg vs 144 mm Hg, P = .001), a greater proportion with cure or improvement of hypertension (96% vs 64%, P = .0034), a greater proportion with biochemical cure of PA on fludrocortisone suppression testing (43 of 49 [88%] vs 4 of 9 [44%], P = .002) and were taking a lower median number of antihypertensive medications (0 vs 1.5, P = .0032). In a multivariate model, the degree of CS and preoperative SBP were both significantly correlated with postoperative SBP, but the lateralization index, sex, and age were not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>In this study, the presence of CS correlated with good BP and biochemical outcomes from surgery. This finding suggests that CS should be a factor in deciding whether to offer surgery for treatment of PA.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2014-3676","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T15:37:20Z","timestamp":1422632240000},"page":"1477-1484","source":"Crossref","is-referenced-by-count":87,"title":["Does Contralateral Suppression at Adrenal Venous Sampling Predict Outcome Following Unilateral Adrenalectomy for Primary Aldosteronism? 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