{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:15:33Z","timestamp":1789852533816,"version":"4.0.1"},"reference-count":52,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Aberrant cellular oxygen sensing is a leading theory for development of pheochromocytoma (PHEO) and paraganglioma (PGL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>The objective of the study was to test the hypothesis that chronic hypoxia in patients with cyanotic congenital heart disease (CCHD) increases the risk for PHEO-PGL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design\/Setting\/Participants:<\/jats:title>\n                  <jats:p>We investigated the association between CCHD and PHEO-PGL with two complementary studies: study 1) an international consortium was established to identify congenital heart disease (CHD) patients with a PHEO-PGL diagnosis confirmed by pathology or biochemistry and imaging; study 2) the 2000\u20132009 Nationwide Inpatient Survey, a nationally representative discharge database, was used to determine population-based cross-sectional PHEO-PGL frequency in hospitalized CCHD patients compared with noncyanotic CHD and those without CHD using multivariable logistic regression adjusted for age, sex, and genetic PHEO-PGL syndromes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>In study 1, we identified 20 PHEO-PGL cases, of which 18 had CCHD. Most presented with cardiovascular or psychiatric symptoms. Median cyanosis duration for the CCHD PHEO-PGL cases was 20 years (range 1\u201357 y). Cases were young at diagnosis (median 31.5 y, range 15\u201357 y) and 7 of 18 had multiple tumors (two bilateral PHEO; six multifocal or recurrent PGL), whereas 11 had single tumors (seven PHEO; four PGL). PGLs were abdominal (13 of 17) or head\/neck (4 of 17). Cases displayed a noradrenergic biochemical phenotype similar to reported hypoxia-related PHEO-PGL genetic syndromes but without clinical signs of such syndromes. In study 2, hospitalized CCHD patients had an increased likelihood of PHEO-PGL (adjusted odds ratio 6.0, 95% confidence interval 2.6\u201313.7, P &amp;lt; .0001) compared with those without CHD; patients with noncyanotic CHD had no increased risk (odds ratio 0.9, P = .48).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>There is a strong link between CCHD and PHEO-PGL. Whether these rare diseases coassociate due to hypoxic stress, common genetic or developmental factors, or some combination requires further investigation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2014-3863","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T18:52:48Z","timestamp":1421088768000},"page":"1325-1334","source":"Crossref","is-referenced-by-count":93,"title":["Pheochromocytoma and Paraganglioma in Cyanotic Congenital Heart Disease"],"prefix":"10.1210","volume":"100","author":[{"given":"Alexander R.","family":"Opotowsky","sequence":"first","affiliation":[{"name":"Department of Cardiology (A.R.O., L.E.M., M.J.L., M.N.S., F.W.), Boston Children's Hospital, Boston, Massachusetts 02115"},{"name":"Division of Cardiovascular Medicine, (A.R.O., M.J.L., M.N.S., F.W.), Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilamarie E.","family":"Moko","sequence":"additional","affiliation":[{"name":"Department of Cardiology (A.R.O., L.E.M., M.J.L., M.N.S., F.W.), Boston Children's Hospital, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Ginns","sequence":"additional","affiliation":[{"name":"Department of Medicine (J.Gi., M.R.), Columbia University Medical Center, New York, New York 10027"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlon","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Department of Medicine (J.Gi., M.R.), Columbia University Medical Center, New York, New York 10027"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Greutmann","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Program (M.G.), University Hospital Zurich, CH-8032 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Aboulhosn","sequence":"additional","affiliation":[{"name":"Department of Medicine (J.A.,A.H.), Division of Cardiology, University of California, Los Angeles, Medical Center, Ahmanson\/UCLA Adult Congenital Heart Disease Center, Los Angeles, California 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbie","family":"Hageman","sequence":"additional","affiliation":[{"name":"Department of Medicine (J.A.,A.H.), Division of Cardiology, University of California, Los Angeles, Medical Center, Ahmanson\/UCLA Adult Congenital Heart Disease Center, Los Angeles, California 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology (Y.K., L.X.D.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"},{"name":"Department of Medicine (Y.K., L.X.D.), Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa X.","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiology (Y.K., L.X.D.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104"},{"name":"Department of Medicine (Y.K., L.X.D.), Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Grewal","sequence":"additional","affiliation":[{"name":"Division of Cardiology (J.Gr.), St Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali N.","family":"Zaidi","sequence":"additional","affiliation":[{"name":"The Heart Center (A.N.Z.), Nationwide Children's Hospital, Columbus, Ohio 43205"},{"name":"Department of Internal Medicine (A.N.Z.), The Ohio State University Wexner Medical Center, Columbus, Ohio 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadeera","family":"Almansoori","sequence":"additional","affiliation":[{"name":"Department of Medicine (G.A., E.O.), University Health Network and University of Toronto, Toronto, Ontario, CanadaM5G2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Oechslin","sequence":"additional","affiliation":[{"name":"Department of Medicine (G.A., E.O.), University Health Network and University of Toronto, Toronto, Ontario, CanadaM5G2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Earing","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (M.E.), Medical College of Wisconsin, Milwaukee, Wisconsin 53226"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Landzberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology (A.R.O., L.E.M., M.J.L., M.N.S., F.W.), Boston Children's Hospital, Boston, Massachusetts 02115"},{"name":"Division of Cardiovascular Medicine, (A.R.O., M.J.L., M.N.S., F.W.), Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiology (A.R.O., L.E.M., M.J.L., M.N.S., F.W.), Boston Children's Hospital, Boston, Massachusetts 02115"},{"name":"Division of Cardiovascular Medicine, (A.R.O., M.J.L., M.N.S., F.W.), Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology (A.R.O., L.E.M., M.J.L., M.N.S., F.W.), Boston Children's Hospital, Boston, Massachusetts 02115"},{"name":"Division of Cardiovascular Medicine, (A.R.O., M.J.L., M.N.S., F.W.), Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (A.V.), Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts 02115"},{"name":"Center for Adrenal Disorders (A.V.), Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"issue":"12","key":"2020071615262570500_B1","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"Hoffman","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2020071615262570500_B2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.hfc.2013.09.005","article-title":"The exceptional and far-flung manifestations of heart failure in Eisenmenger syndrome","volume":"10","author":"Opotowsky","year":"2014","journal-title":"Heart Fail Clin"},{"issue":"6","key":"2020071615262570500_B3","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"5454","key":"2020071615262570500_B4","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","article-title":"Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma","volume":"287","author":"Baysal","year":"2000","journal-title":"Science"},{"issue":"19","key":"2020071615262570500_B5","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1056\/NEJMoa020152","article-title":"Germ-line mutations in nonsyndromic pheochromocytoma","volume":"346","author":"Neumann","year":"2002","journal-title":"N Engl J Med"},{"issue":"10","key":"2020071615262570500_B6","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1158\/1078-0432.CCR-12-0160","article-title":"MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma","volume":"18","author":"Burnichon","year":"2012","journal-title":"Clin Cancer Res"},{"issue":"3","key":"2020071615262570500_B7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ng.533","article-title":"Germline mutations in TMEM127 confer susceptibility to pheochromocytoma","volume":"42","author":"Qin","year":"2010","journal-title":"Nat Genet"},{"issue":"10","key":"2020071615262570500_B8","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1056\/NEJMoa1205119","article-title":"Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia","volume":"367","author":"Zhuang","year":"2012","journal-title":"N Engl J Med"},{"issue":"17","key":"2020071615262570500_B9","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/jnci\/djt201","article-title":"Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction","volume":"105","author":"Jochmanova","year":"2013","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"2020071615262570500_B10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrc3648","article-title":"Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity","volume":"14","author":"Dahia","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"2020071615262570500_B11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/MED.0000000000000059","article-title":"Genetic testing in the clinical care of patients with pheochromocytoma and paraganglioma","volume":"21","author":"Rana","year":"2014","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"6","key":"2020071615262570500_B12","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.beem.2010.10.004","article-title":"Pheochromocytomas: the (pseudo)-hypoxia hypothesis","volume":"24","author":"Favier","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"2020071615262570500_B13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0046-8177(76)80052-4","article-title":"Chief cell hyperplasia in the human carotid body at high altitudes; physiologic and pathologic significance","volume":"7","author":"Arias-Stella","year":"1976","journal-title":"Hum Pathol"},{"issue":"3","key":"2020071615262570500_B14","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/1097-0142(19860201)57:3<672::AID-CNCR2820570346>3.0.CO;2-C","article-title":"High-altitude paragangliomas diagnostic and therapeutic considerations","volume":"57","author":"Rodriguez-Cuevas","year":"1986","journal-title":"Cancer"},{"issue":"2","key":"2020071615262570500_B15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0046-8177(73)80012-7","article-title":"High altitude hypoxia and chemodectomas","volume":"4","author":"Saldana","year":"1973","journal-title":"Hum Pathol"},{"issue":"5 Pt 1","key":"2020071615262570500_B16","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.amjhyper.2003.12.012","article-title":"Susceptibility of the influence of weight on blood pressure in men versus women: lessons from a large-scale study of young adults","volume":"17","author":"Sharabi","year":"2004","journal-title":"Am J Hypertens"},{"issue":"5","key":"2020071615262570500_B17","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jacc.2009.04.037","article-title":"Trends in hospitalizations for adults with congenital heart disease in the U.S","volume":"54","author":"Opotowsky","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2020071615262570500_B18","first-page":"95","article-title":"Current understanding of the O2-signalling mechanism of adrenal chromaffin cells","author":"Thompson","year":"2004","journal-title":"Cell Biol Chromaffin Cells"},{"issue":"2","key":"2020071615262570500_B19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00226032","article-title":"Mitochondrial abnormalities in human phaeochromocytoma","volume":"172","author":"Watanabe","year":"1976","journal-title":"Cell Tissue Res"},{"issue":"5","key":"2020071615262570500_B20","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0002-9343(70)90018-5","article-title":"Extra-adrenal pheochromocytoma. Some electron microscopic and biochemical studies","volume":"48","author":"Cornog","year":"1970","journal-title":"Am J Med"},{"issue":"4","key":"2020071615262570500_B21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/path.1711370404","article-title":"Anatomical variation and quantitative histology of the normal and enlarged carotid body","volume":"137","author":"Smith","year":"1982","journal-title":"J Pathol"},{"issue":"3","key":"2020071615262570500_B22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00439-003-0969-6","article-title":"Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect","volume":"113","author":"Astrom","year":"2003","journal-title":"Hum Genet"},{"issue":"1","key":"2020071615262570500_B23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12022-012-9199-6","article-title":"Signaling pathways in pheochromocytomas and paragangliomas: prospects for future therapies","volume":"23","author":"Nolting","year":"2012","journal-title":"Endocr Pathol"},{"issue":"6","key":"2020071615262570500_B24","doi-asserted-by":"crossref","first-page":"800","DOI":"10.7326\/0003-4819-92-6-800","article-title":"Carotid body paraganglioma regression with relief of hypoxemia","volume":"92","author":"Gruber","year":"1980","journal-title":"Ann Intern Med"},{"key":"2020071615262570500_B25","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1161\/01.CIR.29.5.750","article-title":"Cyanotic malformations of the heart with pheochromocytoma: a report of five cases","volume":"29","author":"Folger","year":"1964","journal-title":"Circulation"},{"issue":"3","key":"2020071615262570500_B26","first-page":"251","article-title":"Congenital heart disease and pheochromocytoma","volume":"112","author":"Reynolds","year":"1966","journal-title":"Am J Dis Child"},{"issue":"1","key":"2020071615262570500_B27","first-page":"18","article-title":"Cyanotic heart disease: \u201clow altitude\u201d risk for carotid body tumor?","volume":"142","author":"Nissenblatt","year":"1978","journal-title":"Johns Hopkins Med J"},{"issue":"11","key":"2020071615262570500_B28","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1002\/1097-0142(19821201)50:11<2513::AID-CNCR2820501143>3.0.CO;2-6","article-title":"Cyanotic congenital heart disease with malignant paraganglioma","volume":"50","author":"Bockelman","year":"1982","journal-title":"Cancer"},{"issue":"4","key":"2020071615262570500_B29","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1213\/00000539-199110000-00024","article-title":"Pheochromocytoma in a patient with Eisenmenger's complex","volume":"73","author":"Rutter","year":"1991","journal-title":"Anesthes Analg"},{"issue":"03","key":"2020071615262570500_B30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1017\/S104795110000425X","article-title":"Double inlet left ventricle associated with a subpulmonary tissue tag, dissection of the pulmonary trunk and pheochromocytoma","volume":"7","author":"Medlicott","year":"1997","journal-title":"Cardiol Young"},{"issue":"4","key":"2020071615262570500_B31","first-page":"452","article-title":"Pheochromocytoma and congenital cyanotic heart disease","volume":"52","author":"Juneja","year":"2000","journal-title":"Indian Heart J"},{"issue":"5","key":"2020071615262570500_B32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1291\/hypres.26.433","article-title":"Two cases of pheochromocytoma associated with tetralogy of Fallot","volume":"26","author":"Kita","year":"2003","journal-title":"Hypertens Res"},{"issue":"4","key":"2020071615262570500_B33","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1213\/01.ANE.0000146433.84742.3A","article-title":"The perioperative management of a patient with complex single ventricle physiology and pheochromocytoma","volume":"100","author":"Sparks","year":"2005","journal-title":"Anesthes Analg"},{"issue":"5","key":"2020071615262570500_B34","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF03017207","article-title":"Case report: retroperitoneoscopic pheochromocytoma removal in an adult with Eisenmenger's syndrome","volume":"55","author":"Bellingham","year":"2008","journal-title":"Can J Anaesth"},{"issue":"1","key":"2020071615262570500_B35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1507\/endocrj.K07E-011","article-title":"A case of malignant pheochromocytoma with Holt-Oram syndrome","volume":"55","author":"Yoshihara","year":"2008","journal-title":"Endocr J"},{"issue":"5","key":"2020071615262570500_B36","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1747-0803.2008.00183.x","article-title":"Single left ventricle and pheochromocytoma","volume":"3","author":"Cheung","year":"2008","journal-title":"Congen Heart Dis"},{"issue":"1","key":"2020071615262570500_B37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3345\/kjp.2008.51.1.93","article-title":"Pheochromocytoma associated with cyanotic congenital heart disease","volume":"51","author":"Chung","year":"2008","journal-title":"Korean J Pediatr"},{"key":"2020071615262570500_B38","doi-asserted-by":"crossref","first-page":"9392","DOI":"10.1186\/1757-1626-2-9392","article-title":"Pentalogy of Fallot and cardiac paraganglioma: a case report","volume":"2","author":"Gabhane","year":"2009","journal-title":"Cases J"},{"issue":"12","key":"2020071615262570500_B39","first-page":"1873","article-title":"Pheochromocytoma in Eisenmenger's syndrome: a therapeutic challenge","volume":"29","author":"Filgueiras-Rama","year":"2010","journal-title":"Rev Port Cardiol"},{"issue":"1","key":"2020071615262570500_B40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4174\/jkss.2012.83.1.65","article-title":"Extra-adrenal pheochromocytoma after operation of congenital heart disease: a case report of 18-year-old boy","volume":"83","author":"Hwang","year":"2012","journal-title":"J Korean Surg Soc"},{"issue":"1","key":"2020071615262570500_B41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1210\/jc.2012-1969","article-title":"Sympathetic paraganglioma in a patient with unrepaired tetralogy of Fallot: a case report and review of the literature","volume":"98","author":"Rich","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2020071615262570500_B42","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1177\/0218492312456979","article-title":"Tetralogy of Fallot with pheochromocytoma: an unusual therapeutic challenge","volume":"21","author":"Balakrishnan","year":"2013","journal-title":"Asian Cardiovasc Thorac Ann"},{"issue":"12","key":"2020071615262570500_B43","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/j.1365-2044.1985.tb10658.x","article-title":"Anaesthesia for carotid body tumour resection in a patient with the Eisenmenger syndrome. A case report","volume":"40","author":"Kraayenbrink","year":"1985","journal-title":"Anaesthesia"},{"issue":"5","key":"2020071615262570500_B44","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.2214\/ajr.134.5.1073","article-title":"Bilateral carotid body tumors and cyanotic heart disease","volume":"134","author":"Hirsch","year":"1980","journal-title":"AJR Am J Roentgenol"},{"issue":"2","key":"2020071615262570500_B45","first-page":"127","article-title":"Bilateral carotid body tumors in a patient with cyanotic congenital heart disease\u2013a case report","volume":"24","author":"Jewkes","year":"1990","journal-title":"Vasc Endovasc Surg"},{"issue":"4","key":"2020071615262570500_B46","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/hrt.77.4.385","article-title":"Chemodectoma in a patient with a single ventricle","volume":"77","author":"Wilmshurst","year":"1997","journal-title":"Heart"},{"issue":"11","key":"2020071615262570500_B47","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/hed.20806","article-title":"Combined endovascular and surgical treatment of carotid body tumor in a patient with thoracic situs solitus","volume":"30","author":"Pecorari","year":"2008","journal-title":"Head Neck"},{"issue":"5","key":"2020071615262570500_B48","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1210\/jcem.86.5.7496","article-title":"Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes","volume":"86","author":"Eisenhofer","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2020071615262570500_B49","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1373\/clinchem.2010.153320","article-title":"Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma","volume":"57","author":"Eisenhofer","year":"2011","journal-title":"Clin Chem"},{"issue":"17","key":"2020071615262570500_B50","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1161\/01.CIR.0000145545.83564.51","article-title":"Abnormalities of neurohormonal and cardiac autonomic nervous activities relate poorly to functional status in Fontan patients","volume":"110","author":"Ohuchi","year":"2004","journal-title":"Circulation"},{"issue":"8","key":"2020071615262570500_B51","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1161\/CIRCULATIONAHA.105.534073","article-title":"Systemic endothelial dysfunction in adults with cyanotic congenital heart disease","volume":"112","author":"Oechslin","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"2020071615262570500_B52","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1161\/01.CIR.0000020009.30736.3F","article-title":"Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart disease","volume":"106","author":"Bolger","year":"2002","journal-title":"Circulation"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/100\/4\/1325\/17635888\/jcem1325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/100\/4\/1325\/17635888\/jcem1325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T02:40:09Z","timestamp":1594953609000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/100\/4\/1325\/2815075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,1]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2014-3863","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,1]]}}}