{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:02:40Z","timestamp":1792425760907,"version":"4.5.0"},"reference-count":22,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"DOI":"10.1210\/jc.2015-2662","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T17:00:59Z","timestamp":1444410059000},"page":"4417-4424","source":"Crossref","is-referenced-by-count":93,"title":["Unilateral Adrenalectomy as a First-Line Treatment of Cushing's Syndrome in Patients With Primary Bilateral Macronodular Adrenal Hyperplasia"],"prefix":"10.1210","volume":"100","author":[{"given":"Emmanuelle","family":"Debillon","sequence":"first","affiliation":[{"name":"Service d'Endocrinologie-Diab\u00e9tologie-Nutrition (E.D., M.B., O.C.), F-38043 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz-line","family":"Velayoudom-Cephise","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie (F.V.-C., A.T.), F-33600 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Salenave","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie et des Maladies de la Reproduction and Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance (S.S., J.Y.)F-94275 Le Kremlin-Bic\u00eatre,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Caron","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie et Maladies M\u00e9taboliques (P.Ca.), Centre Hospitalier Universitaire Larrey, F-31059 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chaffanjon","sequence":"additional","affiliation":[{"name":"Service de Chirugie Endocrine et Thoracique (P.Ch.), F-38043 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Wagner","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Digestive et Endocrinienne (T.W.), Centre Hospitalier Universitaire de Bordeaux, F-33600 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilien","family":"Massoutier","sequence":"additional","affiliation":[{"name":"Centre d'Investigation (M.M.), Clinique, Centre Hospitalier Universitaire de Grenoble, F-38043 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Lambert","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital de Bic\u00eatre, and Service de Chirurgie Digestive et Endocrinienne (B.L.), H\u00f4pital Bic\u00eatre F-94275 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Benoit","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie-Diab\u00e9tologie-Nutrition (E.D., M.B., O.C.), F-38043 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Young","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie et des Maladies de la Reproduction and Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance (S.S., J.Y.)F-94275 Le Kremlin-Bic\u00eatre,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Tabarin","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie (F.V.-C., A.T.), F-33600 Pessac, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chabre","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie-Diab\u00e9tologie-Nutrition (E.D., M.B., O.C.), F-38043 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113443870500_B1","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1056\/NEJMoa1304603","article-title":"ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome","volume":"369","author":"Assie","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113443870500_B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.2009.03689.x","article-title":"Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction","volume":"73","author":"Lacroix","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113443870500_B3","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1056\/NEJMoa1215245","article-title":"Intraadrenal corticotropin in bilateral macronodular adrenal hyperplasia","volume":"369","author":"Louiset","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113443870500_B4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/EJE-08-0550","article-title":"Normal overall mortality rate in Addison's disease, but young patients are at risk of premature death","volume":"160","author":"Erichsen","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113443870500_B5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1210\/jc.2014-3191","article-title":"High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency: a prospective study","volume":"100","author":"Hahner","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"20","key":"key\n\t\t\t\t2019041113443870500_B6","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJM199711133372004","article-title":"Propranolol therapy for ectopic \u03b2-adrenergic receptors in adrenal Cushing's syndrome","volume":"337","author":"Lacroix","year":"1997","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113443870500_B7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1507\/endocrj.53.111","article-title":"A case of adrenocorticotropin-independent bilateral adrenal macronodular hyperplasia (AIMAH) with primary hyperparathyroidism (PHPT)","volume":"53","author":"Sato","year":"2006","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t2019041113443870500_B8","first-page":"747","article-title":"[Catecholamine-dependent hereditary Cushing's syndrome\u2014follow-up after unilateral adrenalectomy]","volume":"97","author":"Imohl","year":"2002","journal-title":"Med Klin (Munich)"},{"key":"key\n\t\t\t\t2019041113443870500_B9","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1507\/endocrj.K08E-370","article-title":"Adrenal Cushing's syndrome due to bilateral macronodular adrenal hyperplasia: prediction of the efficacy of \u03b2-blockade therapy and interest of unilateral adrenalectomy","volume":"56","author":"Mazzuco","year":"2009","journal-title":"Endocr J"},{"key":"key\n\t\t\t\t2019041113443870500_B10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1530\/eje.0.1460237","article-title":"Is unilateral adrenalectomy an alternative treatment for ACTH-independent macronodular adrenal hyperplasia? Long-term follow-up of four cases","volume":"146","author":"Lamas","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113443870500_B11","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/cen.12763","article-title":"An analysis of different therapeutic options in patients with Cushing's syndrome due to bilateral macronodular adrenal hyperplasia: a single-centre experience","volume":"82","author":"Albiger","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113443870500_B12","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1007\/s00268-007-9408-5","article-title":"The role of unilateral adrenalectomy in ACTH-independent macronodular adrenal hyperplasia (AIMAH)","volume":"32","author":"Iacobone","year":"2008","journal-title":"World J Surg"},{"key":"key\n\t\t\t\t2019041113443870500_B13","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.crad.2013.08.017","article-title":"The prevalence of incidentally detected adrenal enlargement on CT","volume":"69","author":"Tang","year":"2014","journal-title":"Clin Radiol"},{"key":"key\n\t\t\t\t2019041113443870500_B14","doi-asserted-by":"crossref","first-page":"943162","DOI":"10.1155\/2014\/943162","article-title":"A comprehensive review on metabolic syndrome","volume":"2014","author":"Kaur","year":"2014","journal-title":"Cardiol Res Pract"},{"key":"key\n\t\t\t\t2019041113443870500_B15","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1136\/bmj.307.6913.1190","article-title":"General practice fundholding: observations on prescribing patterns and costs using the defined daily dose method","volume":"307","author":"Maxwell","year":"1993","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041113443870500_B16","first-page":"197","article-title":"International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes: Diabetes Care 2009;32(7):1327\u20131334","volume":"30","author":"Gillett","year":"2009","journal-title":"Clin Biochem Rev"},{"key":"key\n\t\t\t\t2019041113443870500_B17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2265.2004.02106.x","article-title":"Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency","volume":"61","author":"Mah","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113443870500_B18","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"key\n\t\t\t\t2019041113443870500_B19","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/clinchem\/38.8.1491","article-title":"Simultaneous measurement of cortisol in serum and saliva after different forms of cortisol administration","volume":"38","author":"Tunn","year":"1992","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113443870500_B20","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1590\/S0004-27302007000900007","article-title":"Cellular and molecular abnormalities of a macronodular adrenal hyperplasia causing \u03b2-blocker-sensitive Cushing's syndrome","volume":"51","author":"Mazzuco","year":"2007","journal-title":"Arq Bras Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113443870500_B21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S2213-8587(13)70211-0","article-title":"Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing's syndrome: a 15-year retrospective study","volume":"2","author":"Di Dalmazi","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"key\n\t\t\t\t2019041113443870500_B22","doi-asserted-by":"crossref","first-page":"E253","DOI":"10.1210\/jc.2009-2281","article-title":"Systematic analysis of G protein-coupled receptor gene expression in adrenocorticotropin-independent macronodular adrenocortical hyperplasia identifies novel targets for pharmacological control of adrenal Cushing's syndrome","volume":"95","author":"Assie","year":"2010","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/100\/12\/4417\/10421470\/jcem4417.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T17:59:05Z","timestamp":1718128745000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/100\/12\/4417\/2536287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,1]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2015-2662","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,1]]}}}