{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:56:34Z","timestamp":1791932194841,"version":"4.3.4"},"reference-count":39,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context:<\/jats:title><jats:p>Excessive cardiac long-chain fatty acid (LCFA) metabolism\/storage causes cardiomyopathy in animal models of type 2 diabetes. Medium-chain fatty acids (MCFAs) are absorbed and oxidized efficiently. Data in animal models of diabetes suggest MCFAs may benefit the heart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Our objective was to test the effects of an MCFA-rich diet vs an LCFA-rich diet on plasma lipids, cardiac steatosis, and function in patients with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p>This was a double-blind, randomized, 2-week matched-feeding study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting:<\/jats:title><jats:p>The study included ambulatory patients in the general community.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients:<\/jats:title><jats:p>Sixteen patients, ages 37\u201365 years, with type 2 diabetes, an ejection fraction greater than 45%, and no other systemic disease were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention:<\/jats:title><jats:p>Fourteen days of a diet rich in MCFAs or LCFAs, containing 38% as fat in total, was undertaken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures:<\/jats:title><jats:p>Cardiac steatosis and function were the main outcome measures, with lipidomic changes considered a secondary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The relatively load-independent measure of cardiac contractility, S\u2032, improved in the MCFA group (P &amp;lt; .05). Weight-adjusted stroke volume and cardiac output decreased in the LCFA group (both P &amp;lt; .05). The MCFA, but not the LCFA, diet decreased several plasma sphingolipids, ceramide, and acylcarnitines implicated in diabetic cardiomyopathy, and changes in several sphingolipids correlated with improved fasting insulins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Although a diet high in MCFAs does not change cardiac steatosis, our findings suggest that the MCFA-rich diet alters the plasma lipidome and may benefit or at least not harm cardiac function and fasting insulin levels in humans with type 2 diabetes. Larger, long-term studies are needed to further evaluate these effects in less-controlled settings.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2015-3292","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T18:00:49Z","timestamp":1449770449000},"page":"504-512","source":"Crossref","is-referenced-by-count":45,"title":["A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study"],"prefix":"10.1210","volume":"101","author":[{"given":"Sophia","family":"Airhart","sequence":"first","affiliation":[{"name":"Department of Medicine (S.A.), Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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