{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:46:50Z","timestamp":1787021210445,"version":"build-2736575974"},"reference-count":54,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Primary aldosteronism (PA) is the most common cause of secondary hypertension. Aldosterone excess can cause DNA damage in vitro and in vivo. Single case reports have indicated a coincidence of PA with renal cell carcinoma and other tumors. However, the prevalence of benign and malignant neoplasms in patients with PA has not yet been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Design:<\/jats:title>\n                    <jats:p>In the multicenter MEPHISTO study, the prevalence of benign and malignant tumors was investigated in 335 patients with confirmed PA. Matched hypertensive subjects from the population-based Study of Health in Pomerania cohort served as controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 335 PA patients, 119 (35.5%) had been diagnosed with a tumor at any time, and 30 had two or more neoplasms. Lifetime malignancy occurrence was reported in 9.6% of PA patients compared to 6.0% of hypertensive controls (P = .08). PA patients with a history of malignancy had higher baseline aldosterone levels at diagnosis of PA (P = .009), and a strong association between aldosterone levels and the prevalence of malignancies was observed (P = .03). In total, 157 neoplasms were identified in the PA patients; they were benign in 61% and malignant in 25% of the cases (14% of unknown dignity). Renal cell carcinoma was diagnosed in five patients (13% of all malignancies) and was not reported in controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Compared to hypertensive controls, the prevalence of malignancies was positively correlated with aldosterone levels, tended to be higher in PA patients, but did not differ significantly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2015-3405","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T13:02:54Z","timestamp":1454590974000},"page":"1656-1663","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of Malignancies in Patients With Primary Aldosteronism"],"prefix":"10.1210","volume":"101","author":[{"given":"K.","family":"Lang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I (K.L., K.W., B.H., B.A., S.H.), University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I (K.L., K.W., B.H., B.A., S.H.), University Hospital W\u00fcrzburg, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Clinical Endocrinology (M.Q.), Charit\u00e9 Campus Mitte, Charit\u00e9 University Medicine Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Dietz","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV (A.S.D., M.R.), University Hospital Munich, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wallaschofski","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine (H.W., A.H., N.F.), University Medicine Greifswald, 17489 Greifswald, Germany"},{"name":"Private Practice Endocrinology (H.W.), 99084 Erfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hannemann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine (H.W., A.H., N.F.), University Medicine Greifswald, 17489 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Friedrichs","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine (H.W., A.H., N.F.), University Medicine Greifswald, 17489 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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T.","family":"Fuss","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Mainfranken & Department of Medicine I (C.T.F.), University of Wuerzburg, 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Quack","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical Faculty (L.C.R., I.Q.), Heinrich-Heine University D\u00fcesseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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