{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:28:54Z","timestamp":1790162934438,"version":"4.1.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"DOI":"10.1210\/jc.2015-3415","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T18:01:07Z","timestamp":1447869667000},"page":"4533-4540","source":"Crossref","is-referenced-by-count":68,"title":["Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial"],"prefix":"10.1210","volume":"100","author":[{"given":"Claudia E.","family":"Ramirez","sequence":"first","affiliation":[{"name":"Departments of Medicine (C.E.R., J.L.G., J.M.L., N.J.B., C.A.S.), Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Nian","sequence":"additional","affiliation":[{"name":"Biostatistics (H.N., C.Y.), Vanderbilt University School of Medicine, Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Yu","sequence":"additional","affiliation":[{"name":"Biostatistics (H.N., C.Y.), Vanderbilt University School of Medicine, Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Gamboa","sequence":"additional","affiliation":[{"name":"Departments of Medicine (C.E.R., J.L.G., J.M.L., N.J.B., C.A.S.), Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Luther","sequence":"additional","affiliation":[{"name":"Departments of Medicine (C.E.R., J.L.G., J.M.L., N.J.B., C.A.S.), Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Departments of Medicine (C.E.R., J.L.G., J.M.L., N.J.B., C.A.S.), Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyndya A.","family":"Shibao","sequence":"additional","affiliation":[{"name":"Departments of Medicine (C.E.R., J.L.G., J.M.L., N.J.B., C.A.S.), Nashville, Tennessee 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113232947200_B1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.diabres.2011.10.029","article-title":"IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030","volume":"94","author":"Whiting","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"key\n\t\t\t\t2019041113232947200_B2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113232947200_B3","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0140-6736(06)69420-8","article-title":"Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial","volume":"368","author":"Gerstein","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113232947200_B4","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1056\/NEJMoa1001122","article-title":"Effect of nateglinide on the incidence of diabetes and cardiovascular events","volume":"362","author":"Holman","year":"2010","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113232947200_B5","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/clpt.2011.65","article-title":"Is there clear and convincing evidence of cardiovascular risk with rosiglitazone?","volume":"89","author":"Kaul","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"key\n\t\t\t\t2019041113232947200_B6","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1161\/01.ATV.0000107028.20478.8e","article-title":"Insulin stimulates glucose transport via nitric oxide\/cyclic GMP pathway in human vascular smooth muscle cells","volume":"23","author":"Bergandi","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2019041113232947200_B7","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.freeradbiomed.2012.06.031","article-title":"Inorganic nitrite stimulates pancreatic islet blood flow and insulin secretion","volume":"53","author":"Nystr\u00f6m","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"key\n\t\t\t\t2019041113232947200_B8","doi-asserted-by":"crossref","first-page":"E435","DOI":"10.1152\/ajpendo.00398.2010","article-title":"Long-term treatment with atrial natriuretic peptide inhibits ATP production and insulin secretion in rat pancreatic islets","volume":"300","author":"You","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113232947200_B9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0092-8674(03)00803-1","article-title":"Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor","volume":"115","author":"Matsushita","year":"2003","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041113232947200_B10","doi-asserted-by":"crossref","first-page":"H1627","DOI":"10.1152\/ajpheart.00819.2004","article-title":"Compensatory mechanisms influence hemostasis in setting of eNOS deficiency","volume":"288","author":"Iafrati","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t2019041113232947200_B11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1124\/jpet.109.160168","article-title":"Endogenous nitric oxide contributes to bradykinin-stimulated glucose uptake but attenuates vascular tissue-type plasminogen activator release","volume":"332","author":"Pretorius","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t2019041113232947200_B12","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2337\/db06-0883","article-title":"Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice","volume":"56","author":"Ayala","year":"2007","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113232947200_B13","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.eururo.2007.11.018","article-title":"Daily treatment with sildenafil reverses endothelial dysfunction and oxidative stress in an animal model of insulin resistance","volume":"53","author":"Behr-Roussel","year":"2008","journal-title":"Eur Urol"},{"key":"key\n\t\t\t\t2019041113232947200_B14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2337\/dc08-1862","article-title":"Phosphodiesterase 5 inhibition improves \u03b2-cell function in metabolic syndrome","volume":"32","author":"Hill","year":"2009","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113232947200_B15","doi-asserted-by":"crossref","first-page":"e001001","DOI":"10.1161\/JAHA.114.001001","article-title":"Effect of phosphodiesterase inhibition on insulin resistance in obese individuals","volume":"3","author":"Ho","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"key\n\t\t\t\t2019041113232947200_B16","first-page":"E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"DeFronzo","year":"1979","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113232947200_B17","doi-asserted-by":"crossref","first-page":"E1895","DOI":"10.1210\/jc.2014-2122","article-title":"Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humans","volume":"99","author":"Luther","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113232947200_B18","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1210\/jcem-69-5-1059","article-title":"Dose-response characteristics for arginine-stimulated insulin secretion in man and influence of hyperglycemia","volume":"69","author":"van Haeften","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113232947200_B19","first-page":"329","article-title":"Antigen levels of plasminogen activator inhibitor type 1 in citrated plasma: determination of the contribution of platelets","volume":"20","author":"Grimaudo","year":"1990","journal-title":"Haemostasis"},{"key":"key\n\t\t\t\t2019041113232947200_B20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.thromres.2004.12.005","article-title":"Comparison of soluble thrombomodulin, von Willebrand factor, tPA\/PAI-1 complex, and high-sensitivity CRP concentrations in serum, EDTA plasma, citrated plasma, and acidified citrated plasma (Stabilyte) stored at \u221270 degrees C for 8\u201311 years","volume":"116","author":"Nilsson","year":"2005","journal-title":"Thromb Res"},{"key":"key\n\t\t\t\t2019041113232947200_B21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nprot.2006.375","article-title":"Quantification of F2-isoprostanes as a biomarker of oxidative stress","volume":"2","author":"Milne","year":"2007","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t2019041113232947200_B22","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1681\/ASN.V1341034","article-title":"Use of the albumin\/creatinine ratio to detect microalbuminuria: implications of sex and race","volume":"13","author":"Mattix","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2019041113232947200_B23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00399087","article-title":"Interleukin-1 \u03b2 effects on cyclic GMP and cyclic AMP in cultured rat islets of Langerhans-arginine-dependence and relationship to insulin secretion","volume":"36","author":"Green","year":"1993","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113232947200_B24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1677\/joe.1.06890","article-title":"Nitric oxide inhibits, and carbon monoxide activates, islet acid \u03b1-glucoside hydrolase activities in parallel with glucose-stimulated insulin secretion","volume":"190","author":"Mos\u00e9n","year":"2006","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t2019041113232947200_B25","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1210\/en.2009-0468","article-title":"Atrial natriuretic peptide promotes pancreatic islet \u03b2-cell growth and Akt\/Foxo1a\/cyclin D2 signaling","volume":"150","author":"You","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113232947200_B26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2337\/db10-1116","article-title":"Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin \u03b12\u03b21 in mice","volume":"60","author":"Kang","year":"2011","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113232947200_B27","doi-asserted-by":"crossref","first-page":"8225","DOI":"10.1074\/jbc.273.14.8225","article-title":"Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells","volume":"273","author":"Chen","year":"1998","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113232947200_B28","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2337\/diabetes.49.5.863","article-title":"Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells","volume":"49","author":"Goldberg","year":"2000","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113232947200_B29","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.2337\/diabetes.50.7.1522","article-title":"Transcriptional regulation of plasminogen activator inhibitor type 1 gene by insulin: insights into the signaling pathway","volume":"50","author":"Banfi","year":"2001","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113232947200_B30","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1161\/01.ATV.18.11.1771","article-title":"Natriuretic factors and nitric oxide suppress plasminogen activator inhibitor-1 expression in vascular smooth muscle cells. Role of cGMP in the regulation of the plasminogen system","volume":"18","author":"Bouchie","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2019041113232947200_B31","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1161\/01.CIR.103.14.1869","article-title":"Elevated urinary albumin excretion is associated with impaired arterial dilatory capacity in clinically healthy subjects","volume":"103","author":"Clausen","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113232947200_B32","doi-asserted-by":"crossref","first-page":"552","DOI":"10.2337\/diab.43.4.552","article-title":"Microalbuminuria precedes the development of NIDDM","volume":"43","author":"Mykk\u00e4nen","year":"1994","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113232947200_B33","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1093\/ije\/dyl115","article-title":"Albuminuria as a marker of the risk of developing type 2 diabetes in non-diabetic Aboriginal Australians","volume":"35","author":"Wang","year":"2006","journal-title":"Int J Epidemiol"},{"key":"key\n\t\t\t\t2019041113232947200_B34","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/dmrr.1089","article-title":"Incidence rates and predictors of diabetes in those with prediabetes: the Strong Heart Study","volume":"26","author":"Wang","year":"2010","journal-title":"Diabetes Metab Res Rev"},{"key":"key\n\t\t\t\t2019041113232947200_B35","doi-asserted-by":"crossref","first-page":"F655","DOI":"10.1152\/ajprenal.00309.2006","article-title":"Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat","volume":"292","author":"Knight","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"key\n\t\t\t\t2019041113232947200_B36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1523-1755.1999.00233.x","article-title":"Cyclic-3\u2032,5\u2032-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney","volume":"55","author":"Dousa","year":"1999","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t2019041113232947200_B37","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/j.1476-5381.2010.01149.x","article-title":"Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in non-insulin-dependent Otsuka Long-Evans Tokushima fatty rats","volume":"162","author":"Kuno","year":"2011","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t2019041113232947200_B38","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.diabres.2007.02.006","article-title":"Sildenafil citrate diminishes microalbuminuria and the percentage of A1c in male patients with type 2 diabetes","volume":"78","author":"Grover-P\u00e1ez","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"key":"key\n\t\t\t\t2019041113232947200_B39","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/jama.2013.2024","article-title":"Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial","volume":"309","author":"Redfield","year":"2013","journal-title":"JAMA"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/100\/12\/4533\/10422343\/jcem4533.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T14:31:21Z","timestamp":1653575481000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/100\/12\/4533\/2536350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,1]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2015-3415","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,1]]}}}