{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:48:22Z","timestamp":1787021302205,"version":"build-2736575974"},"reference-count":39,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Adrenal vein sampling (AVS) is required to identify a lateralized or bilateral aldosterone source in primary aldosteronism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Our objectives were to compare basal and post-ACTH selectivity ratio (SR) and lateralization ratio (LR) and to determine the prevalence of basal contralateral suppression and its effect on surgical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Intervention:<\/jats:title>\n                    <jats:p>Bilateral simultaneous adrenal vein samples were obtained before and after a 250-\u03bcg bolus of ACTH. Analyses were conducted on 171 technically successful AVS and on the subgroup of 66 operated patients with evaluable outcome data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>ACTH increased selectivity on both sides from 66.7% in basal samples (SR \u2265 2) to 91.8% poststimulation (SR \u2265 5). A discordance of lateralization between basal (LR \u2265 2) and post-ACTH (LR \u2265 4) values was observed in 28% of cases, which were mostly lateralized cases basally that became bilateral post-ACTH. Basal CL suppression is present in only 30% using absolute ratio of aldosterone between the opposite (nondominant) adrenal vein and the peripheral vein AOPP\/AP below 1.5 vs in 77% using aldosterone\/cortisol ratio (A\/C)OPP\/(A\/C)P below 1.5. The absence of CL suppression was associated with a lower rate of response to adrenalectomy in terms of clinical and biochemical parameters with difference in clinical cure (55% vs 13% P = .0003) and overall cure (35% vs 9%, P = .0084) using AOPP\/AP, but not when using (A\/C)OPP\/(A\/C)P.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Stimulation with ACTH is useful to improve selectivity of AVS but can frequently modify interpretation of lateralization. Basal ratios are as important as post-ACTH ratios to set an indication of adrenalectomy. AOPP\/AP is superior to (A\/C)OPP\/(A\/C)P to assess contralateral suppression. Infrequent CL suppression reveals frequent occurrence of contralateral hyperplasia in lateralized cases and helps predict postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2015-3915","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T13:01:20Z","timestamp":1456491680000},"page":"1826-1835","source":"Crossref","is-referenced-by-count":95,"title":["Basal and Post-ACTH Aldosterone and Its Ratios Are Useful During Adrenal Vein Sampling in Primary Aldosteronism"],"prefix":"10.1210","volume":"101","author":[{"given":"Nada","family":"El Ghorayeb","sequence":"first","affiliation":[{"name":"Department of Medicine (N.E.G., T.L.M., I.B., P.S.Z., A.L.) Qu\u00e9bec, H2W 1T8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia L.","family":"Mazzuco","sequence":"additional","affiliation":[{"name":"Department of Medicine (N.E.G., T.L.M., I.B., P.S.Z., A.L.) Qu\u00e9bec, H2W 1T8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Bourdeau","sequence":"additional","affiliation":[{"name":"Department of Medicine (N.E.G., T.L.M., I.B., P.S.Z., A.L.) Qu\u00e9bec, H2W 1T8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Mailhot","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.-P.M., E.T.), Division of Endocrinology, Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, H2W 1T8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping Shi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medicine (N.E.G., T.L.M., I.B., P.S.Z., A.L.) Qu\u00e9bec, H2W 1T8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Th\u00e9rasse","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.-P.M., E.T.), Division of Endocrinology, Centre de Recherche du Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Universit\u00e9 de Montr\u00e9al, Qu\u00e9bec, H2W 1T8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Department of Medicine (N.E.G., T.L.M., I.B., P.S.Z., A.L.) Qu\u00e9bec, H2W 1T8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071616564706300_B1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-0031-1295438","article-title":"Prevalence of primary aldosteronism in patient's cohorts and in population-based studies\u2013a review of the current literature","volume":"44","author":"Hannemann","year":"2012","journal-title":"Hormone Metab Res"},{"key":"2020071616564706300_B2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/HYPERTENSIONAHA.106.086116","article-title":"Is there an unrecognized epidemic of primary aldosteronism? 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Metab"},{"key":"2020071616564706300_B6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1530\/EJE-08-0711","article-title":"Screening for membrane hormone receptor expression in primary aldosteronism","volume":"160","author":"Zwermann","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"2020071616564706300_B7","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"2020071616564706300_B8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","article-title":"Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing 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(Oxf)"},{"key":"2020071616564706300_B34","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1210\/jc.2014-2345","article-title":"Aldosterone suppression on contralateral adrenal during adrenal vein sampling does not predict blood pressure response after adrenalectomy","volume":"99","author":"Monticone","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616564706300_B35","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1210\/jc.2014-3676","article-title":"Does contralateral suppression at adrenal venous sampling predict outcome following unilateral adrenalectomy for primary aldosteronism? 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