{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:29:59Z","timestamp":1790206199124,"version":"4.1.0"},"reference-count":28,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"DOI":"10.1210\/jc.2015-3993","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T18:42:53Z","timestamp":1452624173000},"page":"1225-1234","source":"Crossref","is-referenced-by-count":46,"title":["Dysfunctional Subcutaneous Fat With Reduced Dicer and Brown Adipose Tissue Gene Expression in HIV-Infected Patients"],"prefix":"10.1210","volume":"101","author":[{"given":"Martin","family":"Torriani","sequence":"first","affiliation":[{"name":"Program in Nutritional Metabolism (M.T., S.S., K.V.F., K.W., E.P., S.K.G.) Boston, Massachusetts 02114"},{"name":"Division of Musculoskeletal Imaging and Intervention (M.T.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Srinivasa","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism (M.T., S.S., K.V.F., K.W., E.P., S.K.G.) Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen V.","family":"Fitch","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism (M.T., S.S., K.V.F., K.W., E.P., S.K.G.) Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thomou","sequence":"additional","affiliation":[{"name":"Section on Integrative Physiology and Metabolism (T.T., C.R.K., A.M.C.), Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Wong","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism (M.T., S.S., K.V.F., K.W., E.P., S.K.G.) Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Petrow","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism (M.T., S.S., K.V.F., K.W., E.P., S.K.G.) Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Ronald","family":"Kahn","sequence":"additional","affiliation":[{"name":"Section on Integrative Physiology and Metabolism (T.T., C.R.K., A.M.C.), Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Cypess","sequence":"additional","affiliation":[{"name":"Section on Integrative Physiology and Metabolism (T.T., C.R.K., A.M.C.), Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215"},{"name":"Translational Physiology Section, Diabetes, Endocrinology, and Obesity Branch, National Institutes of Health\/National Institute of Diabetes and Digestive and Kidney Diseases (A.M.C.), Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Grinspoon","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism (M.T., S.S., K.V.F., K.W., E.P., S.K.G.) Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113235203100_B1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJMra041811","article-title":"Cardiovascular risk and body-fat abnormalities in HIV-infected adults","volume":"352","author":"Grinspoon","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113235203100_B2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/QAD.0b013e3282f56b40","article-title":"Differential gene expression indicates that \u201cbuffalo hump\u201d is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy","volume":"22","author":"Guallar","year":"2008","journal-title":"AIDS"},{"key":"key\n\t\t\t\t2019041113235203100_B3","doi-asserted-by":"crossref","first-page":"e0136571","DOI":"10.1371\/journal.pone.0136571","article-title":"The molecular signature of HIV-1-associated lipomatosis reveals differential involvement of brown and beige\/brite adipocyte cell lineages","volume":"10","author":"Cereijo","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019041113235203100_B4","doi-asserted-by":"crossref","first-page":"E602","DOI":"10.1210\/jc.2011-2951","article-title":"Deiodinase 2 expression is increased in dorsocervical fat of patients with HIV-associated lipohypertrophy syndrome","volume":"97","author":"Torriani","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113235203100_B5","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.2337\/db11-0075","article-title":"Comparison of dorsocervical with abdominal subcutaneous adipose tissue in patients with and without antiretroviral therapy-associated lipodystrophy","volume":"60","author":"Sevastianova","year":"2011","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113235203100_B6","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041113235203100_B7","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.cmet.2012.07.017","article-title":"Role of microRNA processing in adipose tissue in stress defense and longevity","volume":"16","author":"Mori","year":"2012","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t2019041113235203100_B8","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1172\/JCI73468","article-title":"Altered miRNA processing disrupts brown\/white adipocyte determination and associates with lipodystrophy","volume":"124","author":"Mori","year":"2014","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113235203100_B9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cmet.2014.12.009","article-title":"Activation of human brown adipose tissue by a \u03b23-adrenergic receptor agonist","volume":"21","author":"Cypess","year":"2015","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t2019041113235203100_B10","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.15252\/embr.201540837","article-title":"MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1\u03b1 signaling network","volume":"16","author":"Zhang","year":"2015","journal-title":"EMBO Rep"},{"key":"key\n\t\t\t\t2019041113235203100_B11","doi-asserted-by":"crossref","first-page":"e1003626","DOI":"10.1371\/journal.pgen.1003626","article-title":"miR-133a regulates adipocyte browning in vivo","volume":"9","author":"Liu","year":"2013","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t2019041113235203100_B12","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ncb2286","article-title":"Mir193b-365 is essential for brown fat differentiation","volume":"13","author":"Sun","year":"2011","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t2019041113235203100_B13","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/ncb2612","article-title":"MyomiR-133 regulates brown fat differentiation through Prdm16","volume":"14","author":"Trajkovski","year":"2012","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t2019041113235203100_B14","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.metabol.2013.10.004","article-title":"MiR-27 orchestrates the transcriptional regulation of brown adipogenesis","volume":"63","author":"Sun","year":"2014","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113235203100_B15","doi-asserted-by":"crossref","first-page":"e1001314","DOI":"10.1371\/journal.pbio.1001314","article-title":"2012 Essential role for miR-196a in brown adipogenesis of white fat progenitor cells","volume":"10","author":"Mori","journal-title":"PLoS Biol"},{"key":"key\n\t\t\t\t2019041113235203100_B16","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/ncomms2742","article-title":"miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit","volume":"4","author":"Chen","year":"2013","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t2019041113235203100_B17","first-page":"415","article-title":"Emergence of a complex relationship between HIV-1 and the microRNA pathway","volume":"487","author":"Ouellet","year":"2009","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t2019041113235203100_B18","doi-asserted-by":"crossref","first-page":"31930","DOI":"10.1074\/jbc.M110.101709","article-title":"Absence of DICER in monocytes and its regulation by HIV-1","volume":"285","author":"Coley","year":"2010","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113235203100_B19","doi-asserted-by":"crossref","first-page":"e1005153","DOI":"10.1371\/journal.ppat.1005153","article-title":"Adipose tissue is a neglected viral reservoir and an inflammatory site during chronic HIV and SIV infection","volume":"11","author":"Damouche","year":"2015","journal-title":"PLOS Pathog"},{"key":"key\n\t\t\t\t2019041113235203100_B20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/QAD.0000000000000599","article-title":"Human adipose tissue as a reservoir for memory CD4+ T cells and HIV","volume":"29","author":"Couturier","year":"2015","journal-title":"AIDS"},{"key":"key\n\t\t\t\t2019041113235203100_B21","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1177\/135965350400900607","article-title":"Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro","volume":"9","author":"Lagathu","year":"2004","journal-title":"Antivir Ther"},{"key":"key\n\t\t\t\t2019041113235203100_B22","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1152\/ajpendo.00249.2011","article-title":"Recruited vs. nonrecruited molecular signatures of brown, \u201cbrite,\u201d and white adipose tissues","volume":"302","author":"Wald\u00e9n","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113235203100_B23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nm.3112","article-title":"Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat","volume":"19","author":"Cypess","year":"2013","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041113235203100_B24","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cmet.2014.07.025","article-title":"Brown fat in humans: consensus points and experimental guidelines","volume":"20","author":"Cypess","year":"2014","journal-title":"Cell Metab"},{"key":"key\n\t\t\t\t2019041113235203100_B25","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/00002030-200404090-00018","article-title":"Uncoupling protein 1 gene expression implicates brown adipocytes in highly active antiretroviral therapy-associated lipomatosis","volume":"18","author":"Rodriguez de la Concepcion","year":"2004","journal-title":"AIDS"},{"key":"key\n\t\t\t\t2019041113235203100_B26","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1038\/oby.2011.231","article-title":"Brown fat activity is not apparent in subjects with HIV lipodystrophy and increased resting energy expenditure","volume":"19","author":"Kosmiski","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"key\n\t\t\t\t2019041113235203100_B27","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/jc.2011-1159","article-title":"Lipodystrophies: genetic and acquired body fat disorders","volume":"96","author":"Garg","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113235203100_B28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.virol.2013.06.010","article-title":"The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection","volume":"444","author":"Casey Klockow","year":"2013","journal-title":"Virology"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/101\/3\/1225\/10429562\/jcem1225.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T13:08:34Z","timestamp":1654088914000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/101\/3\/1225\/2499538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,1]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2015-3993","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,1]]}}}