{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:42:57Z","timestamp":1777520577623,"version":"3.51.4"},"reference-count":41,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Testosterone increases skeletal muscle mass and strength, but the effects of testosterone on aerobic performance in mobility-limited older men have not been evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To determine the effects of testosterone supplementation on aerobic performance, assessed as peak oxygen uptake (V\u0307O2peak) and gas exchange lactate threshold (V\u0307O2\u03b8), during symptom-limited incremental cycle ergometer exercise.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p>Subgroup analysis of the Testosterone in Older Men with Mobility Limitations Trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting:<\/jats:title>\n                  <jats:p>Exercise physiology laboratory in an academic medical center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants:<\/jats:title>\n                  <jats:p>Sixty-four mobility-limited men 65 years or older with low total (100\u2013350 ng\/dL) or free (&amp;lt;50 pg\/dL) testosterone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions:<\/jats:title>\n                  <jats:p>Participants were randomized to receive 100-mg testosterone gel or placebo gel daily for 6 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures:<\/jats:title>\n                  <jats:p>V\u0307O2peak and V\u0307O2\u03b8 from a symptom-limited cycle exercise test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Mean (SD) baseline V\u0307O2peak was 20.5 (4.3) and 19.9 (4.7) mL\/kg\/min for testosterone and placebo, respectively. V\u0307O2peak increased by 0.83 (2.4) mL\/kg\/min in testosterone but decreased by \u22120.89 (2.5) mL\/kg\/min in placebo (P = .035); between group difference in change in V\u0307O2peak was significant (P = .006). This 6-month reduction in placebo was greater than the expected \u22120.4-mL\/kg\/min\/y rate of decline in the general population. V\u0307O2\u03b8 did not change significantly in testosterone but decreased by 1.1 (1.8) mL\/kg\/min in placebo, P = .011 for between-group comparisons. Hemoglobin increased by 1.0 \u00b1 3.5 and 0.1 \u00b1 0.8 g\/dL in testosterone and placebo groups, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Testosterone supplementation in mobility-limited older men increased hemoglobin and attenuated the age-related declines in V\u0307O2peak and V\u0307O2\u03b8. Long-term intervention studies are needed to determine the durability of this effect.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2015-4333","type":"journal-article","created":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T18:47:00Z","timestamp":1459968420000},"page":"2562-2569","source":"Crossref","is-referenced-by-count":33,"title":["Testosterone Attenuates Age-Related Fall in Aerobic Function in Mobility Limited Older Men With Low Testosterone"],"prefix":"10.1210","volume":"101","author":[{"given":"Thomas W.","family":"Storer","sequence":"first","affiliation":[{"name":"Research Program in Men's Health: Aging and Metabolism (T.W.S., S.Bh., T.G.T., K.P., J.M., S.Ba.), Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalender","family":"Bhasin","sequence":"additional","affiliation":[{"name":"Research Program in Men's Health: Aging and Metabolism (T.W.S., S.Bh., T.G.T., K.P., J.M., S.Ba.), Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Travison","sequence":"additional","affiliation":[{"name":"Research Program in Men's Health: Aging and Metabolism (T.W.S., S.Bh., T.G.T., K.P., J.M., S.Ba.), Boston, Massachusetts 02115"},{"name":"Hebrew SeniorLife Institute for Aging Research (T.G.T.), Roslindale, Massachusetts 02131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Pencina","sequence":"additional","affiliation":[{"name":"Research Program in Men's Health: Aging and Metabolism (T.W.S., S.Bh., T.G.T., K.P., J.M., S.Ba.), Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Miciek","sequence":"additional","affiliation":[{"name":"Boston Claude D. 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