{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:24:52Z","timestamp":1774448692376,"version":"3.50.1"},"reference-count":39,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Unfavorable lipid levels contribute to cardiovascular disease and may also harm bone health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>Our objective was to investigate relationships between fasting plasma lipid levels and incident fracture in midlife women undergoing the menopausal transition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Setting:<\/jats:title>\n                  <jats:p>This was a 13-year prospective, longitudinal study of multiethnic women in five US communities, with near-annual assessments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants:<\/jats:title>\n                  <jats:p>At baseline, 2062 premenopausal or early perimenopausal women who had no history of fracture were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Exposures:<\/jats:title>\n                  <jats:p>Fasting plasma total cholesterol, triglycerides (TG), low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol at baseline and follow-up visits 1 and 3\u20137.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure(s):<\/jats:title>\n                  <jats:p>Incident nontraumatic fractures 1) 2 or more years after baseline, in relation to a single baseline level of lipids; and 2) 2\u20135 years later, in relation to time-varying lipid levels. Cox proportional hazards modelings estimated hazard ratios and 95% confidence interval (CI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Among the lipids, TG levels changed the most, with median levels increased by 16% during follow-up. An increase of 50 mg\/dl in baseline TG level was associated with a 1.1-fold increased hazards of fracture (adjusted hazard ratio, 1.11; 95% CI, 1.04\u20131.18). Women with baseline TG higher than 300 mg\/dl had an adjusted 2.5-fold greater hazards for fractures (95% CI, 1.13\u20135.44) than women with baseline TG lower than 150 mg\/dl. Time-varying analyses showed a comparable TG level-fracture risk relationship. Associations between total cholesterol, low-density lipoprotein cholesterol, or high-density lipoprotein cholesterol levels and fractures were not observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Midlife women with high fasting plasma TG had an increased risk of incident nontraumatic fracture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Secondary Abstract:<\/jats:title>\n                  <jats:p>Midlife women with fasting plasma triglyceride (TG) of at least 300 mg\/dl had 2.5-fold greater hazards of fracture in 2 years later and onward, compared to those with TG below 150 mg\/dl, in a multiethnic cohort. Time-varying analyses revealed comparable results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2016-1366","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T20:40:11Z","timestamp":1465850411000},"page":"3297-3305","source":"Crossref","is-referenced-by-count":32,"title":["Triglyceride Levels and Fracture Risk in Midlife Women: Study of Women's Health Across the Nation (SWAN)"],"prefix":"10.1210","volume":"101","author":[{"given":"Po-Yin","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Gerontology, and Metabolism (P.-Y.C., J.S.L.), Department of Medicine, Stanford University School of Medicine, Stanford, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen B.","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences (E.B.G.), University of California, Davis, Davis, 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