{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:36:31Z","timestamp":1790192191233,"version":"4.1.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"DOI":"10.1210\/jc.2016-1402","type":"journal-article","created":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T17:20:48Z","timestamp":1459272048000},"page":"2683-2691","source":"Crossref","is-referenced-by-count":47,"title":["Evaluation of Circulating Determinants of Beta-Cell Function in Women With and Without Gestational Diabetes"],"prefix":"10.1210","volume":"101","author":[{"given":"Ravi","family":"Retnakaran","sequence":"first","affiliation":[{"name":"Leadership Sinai Centre for Diabetes (R.R., C.Y., C.K.K., A.J.H., B.Z.), Mt Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Division of Endocrinology (R.R., C.K.K., P.W.C., A.J.H., B.Z.), University of Toronto, Toronto, Ontario, Canada"},{"name":"Lunenfeld-Tanenbaum Research Institute (R.R., B.Z.), Mt Sinai Hospital, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Ye","sequence":"additional","affiliation":[{"name":"Leadership Sinai Centre for Diabetes (R.R., C.Y., C.K.K., A.J.H., B.Z.), Mt Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline K.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Leadership Sinai Centre for Diabetes (R.R., C.Y., C.K.K., A.J.H., B.Z.), Mt Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Division of Endocrinology (R.R., C.K.K., P.W.C., A.J.H., B.Z.), University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W.","family":"Connelly","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (R.R., C.K.K., P.W.C., A.J.H., B.Z.), University of Toronto, Toronto, Ontario, Canada"},{"name":"Keenan Research Centre for Biomedical Science of St. Michael's Hospital (P.W.C.), Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Hanley","sequence":"additional","affiliation":[{"name":"Leadership Sinai Centre for Diabetes (R.R., C.Y., C.K.K., A.J.H., B.Z.), Mt Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Division of Endocrinology (R.R., C.K.K., P.W.C., A.J.H., B.Z.), University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Nutritional Sciences (A.J.H.), University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Sermer","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology (M.S.), Mt Sinai Hospital, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Zinman","sequence":"additional","affiliation":[{"name":"Leadership Sinai Centre for Diabetes (R.R., C.Y., C.K.K., A.J.H., B.Z.), Mt Sinai Hospital, Toronto, Ontario, Canada"},{"name":"Division of Endocrinology (R.R., C.K.K., P.W.C., A.J.H., B.Z.), University of Toronto, Toronto, Ontario, Canada"},{"name":"Lunenfeld-Tanenbaum Research Institute (R.R., B.Z.), Mt Sinai Hospital, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041116123718700_B1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2337\/db14-0877","article-title":"New insights into gestational glucose metabolism: lessons learned from 21st century approaches","volume":"64","author":"Angueira","year":"2015","journal-title":"Diabetes"},{"key":"2019041116123718700_B2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/157339909789804378","article-title":"Glucose tolerance status in pregnancy: a window to the future risk of diabetes and cardiovascular disease in young women","volume":"5","author":"Retnakaran","year":"2009","journal-title":"Curr Diabetes Rev"},{"key":"2019041116123718700_B3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2217\/dmt.10.24","article-title":"Mechanisms in the adaptation of maternal beta-cells in pregnancy","volume":"1","author":"Ernst","year":"2011","journal-title":"Diabetes Manag"},{"key":"2019041116123718700_B4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/MED.0b013e32834c800d","article-title":"Placental hormones and the control of maternal metabolism and fetal growth","volume":"18","author":"Newbern","year":"2011","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2019041116123718700_B5","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1007\/s00125-010-1809-6","article-title":"Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy","volume":"53","author":"Butler","year":"2010","journal-title":"Diabetologia"},{"key":"2019041116123718700_B6","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s00125-010-1848-z","article-title":"Beta-cell adaptation in pregnancy: a major difference between humans and rodents","volume":"51","author":"Genevay","year":"2010","journal-title":"Diabetologia"},{"key":"2019041116123718700_B7","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/aogs.12505","article-title":"Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy","volume":"93","author":"Nalla","year":"2014","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2019041116123718700_B8","first-page":"64","article-title":"The role of non-placental signals in the adaptation of islets to pregnancy","volume":"47","author":"Drynda","year":"2015","journal-title":"Horm Metab Res"},{"key":"2019041116123718700_B9","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1007\/s00125-015-3670-0","article-title":"Prolactin-stimulated survivin induction is required for beta cell mass expansion during pregnancy in mice","volume":"58","author":"Xu","year":"2015","journal-title":"Diabetologia"},{"key":"2019041116123718700_B10","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1055\/s-0031-1284353","article-title":"Prolactin and lactation as modifiers of diabetes risk in gestational diabetes","volume":"43","author":"Ramos-Rom\u00e1n","year":"2011","journal-title":"Horm Metab Res"},{"key":"2019041116123718700_B11","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1210\/en.2008-1003","article-title":"Prolactin receptor is required for normal glucose homeostasis and modulation of beta-cell mass during pregnancy","volume":"150","author":"Huang","year":"2009","journal-title":"Endocrinology"},{"key":"2019041116123718700_B12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.cmet.2014.03.008","article-title":"The furan fatty acid metabolite CMPF is elevated in diabetes and induces \u03b2 cell dysfunction","volume":"19","author":"Prentice","year":"2014","journal-title":"Cell Metab"},{"key":"2019041116123718700_B13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cmet.2014.03.020","article-title":"Lipotoxicity, beta-cell dysfunction, and gestational diabetes","volume":"19","author":"Nolan","year":"2014","journal-title":"Cell Metab"},{"key":"2019041116123718700_B14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1530\/acta.0.0800365","article-title":"Human placental lactogen concentration during physiological fluctuations of serum glucose in normal pregnant and gestational diabetic women","volume":"80","author":"K\u00fchl","year":"1975","journal-title":"Acta Endocrinol"},{"key":"2019041116123718700_B15","first-page":"17","article-title":"Prolactin and glucose tolerance in normal and gestational diabetic pregnancy","volume":"67","author":"Skouby","year":"1986","journal-title":"Obstet Gynecol"},{"key":"2019041116123718700_B16","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2337\/diab.41.12.1651","article-title":"Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women","volume":"41","author":"Montelongo","year":"1992","journal-title":"Diabetes"},{"key":"2019041116123718700_B17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000292468","article-title":"Growth hormone-binding protein in plasma is inversely correlated to placental lactogen and augmented with increasing body mass index in healthy pregnant women and women with gestational diabetes mellitus","volume":"38","author":"Luthman","year":"1994","journal-title":"Gynecol Obstet Invest"},{"key":"2019041116123718700_B18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000010225","article-title":"Hormonal parameters in gestational diabetes mellitus during the third trimester: high glucagon levels","volume":"49","author":"Grigorakis","year":"2000","journal-title":"Gynecol Obstet Invest"},{"key":"2019041116123718700_B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1056-8727(97)00007-X","article-title":"Elevated lipoprotein lipids and gestational hormones in women with diet-treated gestational diabetes mellitus compared to healthy pregnant controls","volume":"12","author":"Couch","year":"1998","journal-title":"J Diabetes Complications"},{"key":"2019041116123718700_B20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1068-607X(98)00112-7","article-title":"Combining human placental lactogen with routine glucose challenge tests","volume":"5","author":"Henderson","year":"1998","journal-title":"Prim Care Update Ob Gyns"},{"key":"2019041116123718700_B21","doi-asserted-by":"crossref","first-page":"844","DOI":"10.2337\/dc14-2551","article-title":"Fetal sex and maternal risk of gestational diabetes mellitus: the impact of having a boy","volume":"38","author":"Retnakaran","year":"2015","journal-title":"Diabetes Care"},{"key":"2019041116123718700_B22","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2337\/diab.28.12.1039","article-title":"Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance","volume":"28","author":"National Diabetes Data Group","year":"1979","journal-title":"Diabetes"},{"key":"2019041116123718700_B23","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"2019041116123718700_B24","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.2337\/diacare.24.9.1602","article-title":"Clinically useful estimates of insulin sensitivity during pregnancy: validation studies in women with normal glucose tolerance and gestational diabetes mellitus","volume":"24","author":"Kirwan","year":"2001","journal-title":"Diabetes Care"},{"key":"2019041116123718700_B25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"2019041116123718700_B26","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/oby.2008.307","article-title":"Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test","volume":"16","author":"Retnakaran","year":"2008","journal-title":"Obesity"},{"key":"2019041116123718700_B27","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/j.1464-5491.2009.02841.x","article-title":"Evaluation of proposed oral disposition index measures in relation to the actual disposition index","volume":"26","author":"Retnakaran","year":"2009","journal-title":"Diabetes Med"},{"key":"2019041116123718700_B28","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm.2173","article-title":"Serotonin regulates pancreatic beta cell mass during pregnancy","volume":"16","author":"Kim","year":"2010","journal-title":"Nat Med"},{"key":"2019041116123718700_B29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2337\/db09-0050","article-title":"Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen","volume":"59","author":"Zhang","year":"2010","journal-title":"Diabetes"},{"key":"2019041116123718700_B30","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.1146812","article-title":"Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus","volume":"318","author":"Karnik","year":"2007","journal-title":"Science"},{"key":"2019041116123718700_B31","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00125-009-1321-z","article-title":"The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality","volume":"52","author":"Kahn","year":"2009","journal-title":"Diabetologia"},{"key":"2019041116123718700_B32","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1089\/gtmb.2013.0009","article-title":"Prolactin receptor gene polymorphisms are associated with gestational diabetes","volume":"17","author":"Le","year":"2013","journal-title":"Genet Test Mol Biomarkers"},{"key":"2019041116123718700_B33","doi-asserted-by":"crossref","first-page":"e0124379","DOI":"10.1371\/journal.pone.0124379","article-title":"CMPF does not associate with impaired glucose metabolism in individuals with features of metabolic syndrome","volume":"10","author":"Lankinen","year":"2015","journal-title":"PLoS One"},{"key":"2019041116123718700_B34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/humupd\/dmt013","article-title":"Genetic variants and the risk of gestational diabetes mellitus: a systematic review","volume":"19","author":"Zhang","year":"2013","journal-title":"Hum Reprod Update"},{"key":"2019041116123718700_B35","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.bcp.2012.07.033","article-title":"A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate","volume":"84","author":"Miyamoto","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"2019041116123718700_B36","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/BF02535166","article-title":"The common occurrence of furan fatty acids in plants","volume":"24","author":"Hannemann","year":"1989","journal-title":"Lipids"},{"key":"2019041116123718700_B37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.chemphyslip.2012.02.004","article-title":"A detailed identification study on high-temperature degradation products of oleic and linoleic acid methyl esters by GC-MS and GC-FTIR","volume":"165","author":"Berdeaux","year":"2012","journal-title":"Chem Phys Lipids"},{"key":"2019041116123718700_B38","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1172\/JCI64151","article-title":"MicroRNAs contribute to compensatory \u03b2 cell expansion during pregnancy and obesity","volume":"122","author":"Jacovetti","year":"2012","journal-title":"J Clin Invest"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/101\/7\/2683\/10427115\/jcem2683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T01:43:03Z","timestamp":1555033383000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/101\/7\/2683\/2810161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,1]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2016-1402","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,1]]}}}