{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T13:21:17Z","timestamp":1742390477278},"reference-count":40,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"Abstract<\/jats:title>Context:<\/jats:title>Multiple diseases may explain the association of the growth hormone\/insulinlike growth factor-I (GH\/IGF-I) axis with longevity.<\/jats:p><\/jats:sec>Objective:<\/jats:title>To relate circulating GH\/IGF-I system protein levels with major health events<\/jats:p><\/jats:sec>Design and Setting:<\/jats:title>This is a cohort study set in 4 US communities.<\/jats:p><\/jats:sec>Participants:<\/jats:title>Adults (N = 2268) 65 years and older free of diabetes and cardiovascular disease<\/jats:p><\/jats:sec>Measurements:<\/jats:title>We assessed insulinlike growth factor binding protein-1 (IGFBP-1) and ghrelin in fasting and 2-hour oral glucose tolerance test (OGTT) blood samples, as well as fasting IGF-I and IGFBP-3. Hazard ratios for mortality and a composite outcome for first incident myocardial infarction, stroke, heart failure, hip fracture, or death were adjusted for sociodemographic, behavioral, and physiological covariates.<\/jats:p><\/jats:sec>Results:<\/jats:title>During 13,930 person-years of follow-up, 48.1% of individuals sustained one or more components of the composite outcome and 31.8% died. Versus the lowest quartiles, the highest quartiles of fasting and 2-hour ghrelin were associated with 27% higher (95% confidence interval [CI]: 6%, 53%) and 39% higher (95% CI: 14%, 71%) risks of the composite outcome, respectively. The highest quartile of 2-hour IGFBP-1 was associated with 35% higher (95% CI: 1%, 52%) risk of the composite end point. Similarly, higher mortality was significantly associated with higher fasting and 2-hour ghrelin levels and with 2-hour IGFBP-1 level. When examined together, 2-hour post-OGTT levels of IGFBP-1 and ghrelin tended to predict outcomes better than fasting levels.<\/jats:p><\/jats:sec>Conclusions:<\/jats:title>Circulating IGFBP-1 and ghrelin measured during an OGTT predicted major health events and death in older adults, which may explain the influence of the GH\/IGF-I axis on lifespan and health.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2016-2779","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T19:00:54Z","timestamp":1478545254000},"page":"267-278","source":"Crossref","is-referenced-by-count":18,"title":["Insulinlike Growth Factor Binding Protein-1 and Ghrelin Predict Health Outcomes Among Older Adults: Cardiovascular Health Study Cohort"],"prefix":"10.1210","volume":"102","author":[{"given":"Robert C.","family":"Kaplan","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health 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