{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:49:40Z","timestamp":1789184980461,"version":"build-2803163510"},"reference-count":28,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context:<\/jats:title><jats:p>Total pancreatectomy with islet auto transplantation (TPIAT) is a treatment for medically refractory chronic pancreatitis that can prevent postsurgical diabetes in some patients. Predictors of insulin independence are needed for appropriate patient selection and counseling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>To explore glycemic predictors of insulin independence after TPIAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design:<\/jats:title><jats:p>A prospective cohort of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We investigated 34 patients undergoing TPIAT from 2011-2016 at Johns Hopkins Hospital, all had a 75-g oral glucose tolerance test (OGTT) administered prior to their TPIAT. The primary outcome was insulin independence 1 year after TPIAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Ten of 34 (29%) patients were insulin independent 1 year after TPIAT. All patients with impaired fasting glucose and\/or impaired glucose tolerance preoperatively were insulin dependent at 1 year. In age-adjusted regression analyses, fasting glucose \u2264 90 mg\/dL [odds ratio (OR) = 6.56; 1.11 to 38.91; P = 0.04], 1-hour OGTT glucose \u2264 143 mg\/dL (OR = 6.65; 1.11 to 39.91; P = 0.04), and 2-hour OGTT glucose \u2264 106 mg\/dL (OR = 11.74; 1.46 to 94.14; P = 0.02) were significant predictors of insulin independence. In receiver operating characteristic analyses, homeostatic model assessment of \u03b2-cell function (HOMA-\u03b2) was the most robust predictor of insulin independence [area under the curve (AUC) = 0.88; 0.73 to 1.00].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Normal preoperative glucose status and lower fasting and postchallenge OGTT glucose values are significant predictors of insulin independence after TPIAT. Higher islet function (HOMA-\u03b2) was the strongest predictor. OGTT testing may be a useful tool to aid in patient counseling prior to TPIAT and should be further investigated.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2016-2952","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T19:09:44Z","timestamp":1479755384000},"page":"801-809","source":"Crossref","is-referenced-by-count":50,"title":["Glycemic Predictors of Insulin Independence After Total Pancreatectomy With Islet Autotransplantation"],"prefix":"10.1210","volume":"102","author":[{"given":"Michael","family":"Quartuccio","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Hall","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikesh","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of 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