{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:39:31Z","timestamp":1778125171995,"version":"3.51.4"},"reference-count":36,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Hypercalciuria is an adverse event of postsurgical hypoparathyroidism treatment that can lead to renal complications. The collection of 24-hour urine to detect hypercalciuria is often considered unreliable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>The purpose of this study was to find useful predictive biomarkers of hypercalciuria in patients with permanent postsurgical hypoparathyroidism receiving treatment with oral calcium and calcitriol supplements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Setting:<\/jats:title>\n                  <jats:p>The investigation was designed as a prospective cross-sectional study. An outpatient hospital clinic served as the study setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients:<\/jats:title>\n                  <jats:p>Fifty-four consecutive observations were made of 34 stable outpatients with postsurgical hypoparathyroidism taking oral calcium and calcitriol supplements, and 17 adult controls without hypoparathyroidism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention:<\/jats:title>\n                  <jats:p>There were no interventions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure:<\/jats:title>\n                  <jats:p>Hypercalciuria was defined as 24-hour urine calcium &amp;gt;300 mg.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Patients without hypercalciuria (n = 21) vs those with hypercalciuria (n = 33) had lower levels of serum 1,25-dihydroxyvitamin D (33.5 \u00b1 11.9 pg\/mL vs 45.8 \u00b1 9.5 pg\/mL; P &amp;lt; 0.001), similar albumin-corrected serum calcium (8.3 \u00b1 0.5 vs 8.6 \u00b1 0.5 mg\/dL; P = nonsignificant), and serum parathyroid hormone (12.5 \u00b1 5.7 vs 10.7 \u00b1 6.8 pg\/mL; P = nonsignificant). Multiple linear regression analysis showed an independent relationship between 1,25-dihydroxyvitamin D and urinary calcium excretion (B = 6.2 \u00b1 1.423; P &amp;lt; 0.001). A cutoff value of 33.5 pg\/mL for serum 1,25-dihydroxyvitamin D to predict the absence of hypercalciuria had 100% sensitivity and 63.6% specificity, and the area under the receiver operating characteristic curve was 0.797. No patients with serum 1,25-dihydroxyvitamin D levels of &amp;lt;33.5 pg\/mL presented with hypercalciuria, regardless of the level of albumin-corrected serum calcium.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Routine measurement of serum 1,25-dihydroxyvitamin D may be useful as a biomarker to predict the absence of hypercalciuria in patients with permanent postsurgical hypoparathyroidism who are receiving treatment with oral calcium and calcitriol supplements.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2016-2987","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T18:01:47Z","timestamp":1478282507000},"page":"259-266","source":"Crossref","is-referenced-by-count":8,"title":["Serum 1,25-Dihydroxyvitamin D as a Biomarker of the Absence of Hypercalciuria in Postsurgical Hypoparathyroidism"],"prefix":"10.1210","volume":"102","author":[{"given":"Luis","family":"Garc\u00eda-Pascual","sequence":"first","affiliation":[{"name":"Service of Endocrinology, Hospital Universitari M\u00fatua de Terrassa, Terrassa, 08221 Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Barahona","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Hospital Universitari M\u00fatua de Terrassa, Terrassa, 08221 Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Perea","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Hospital Universitari M\u00fatua de Terrassa, Terrassa, 08221 Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Sim\u00f3","sequence":"additional","affiliation":[{"name":"Diabetes Research and Metabolism Unit, Institut de Recerca Hospital Universitari Vall d\u2019Hebron, Barcelona, 08035 Spain; and"},{"name":"Department of Medicine, Autonomous University of Barcelona, Barcelona, 08193 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"issue":"3","key":"2020071614181857500_B1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S0022215106003501","article-title":"Parathyroid risk in total thyroidectomy for bilateral, benign, multinodular goitre: report of 351 surgical cases","volume":"121","author":"Page","year":"2007","journal-title":"J Laryngol Otol"},{"issue":"9","key":"2020071614181857500_B2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1089\/thy.2008.0306","article-title":"Postoperative hypoparathyroidism: medical and surgical therapeutic options","volume":"19","author":"Walker Harris","year":"2009","journal-title":"Thyroid"},{"issue":"12","key":"2020071614181857500_B3","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1210\/jc.2012-1808","article-title":"Long-term follow-up of patients with hypoparathyroidism","volume":"97","author":"Mitchell","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2020071614181857500_B4","doi-asserted-by":"crossref","first-page":"674","DOI":"10.4158\/EP14462.DSC","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology disease state clinical review: postoperative hypoparathyroidiism\u2014definitions and management","volume":"21","author":"Stack","year":"2015","journal-title":"Endocr Pract"},{"issue":"2","key":"2020071614181857500_B5","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-15-0628","article-title":"European Society of Endocrinology clinical guideline: treatment of chronic hypoparathyroidism in adults","volume":"173","author":"Bollerslev","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"2020071614181857500_B6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1055\/s-2005-865724","article-title":"Dihydrotachysterol therapy for hypoparathyroidism: consequences of inadequate monitoring. 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