{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:52:41Z","timestamp":1791420761999,"version":"4.3.3"},"reference-count":32,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"vor","delay-in-days":98,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to androgen excess in women with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>One hundred fourteen women with PCOS and 49 healthy control subjects underwent measurement of serum androgens by liquid chromatography-tandem mass spectrometry. Twenty-four\u2013hour urinary androgen excretion was analyzed by gas chromatography-mass spectrometry. Fasting plasma insulin and glucose were measured for homeostatic model assessment of insulin resistance. Baseline demographic data, including body mass index, were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>As expected, serum concentrations of the classic androgens testosterone (P &amp;lt; 0.001), androstenedione (P &amp;lt; 0.001), and dehydroepiandrosterone (P &amp;lt; 0.01) were significantly increased in PCOS. Mirroring this, serum 11-oxygenated androgens 11\u03b2-hydroxyandrostenedione, 11-ketoandrostenedione, 11\u03b2-hydroxytestosterone, and 11-ketotestosterone were significantly higher in PCOS than in control subjects, as was the urinary 11-oxygenated androgen metabolite 11\u03b2-hydroxyandrosterone. The proportionate contribution of 11-oxygenated to total serum androgens was significantly higher in patients with PCOS compared with control subjects [53.0% (interquartile range, 48.7 to 60.3) vs 44.0% (interquartile range, 32.9 to 54.9); P &amp;lt; 0.0001]. Obese (n = 51) and nonobese (n = 63) patients with PCOS had significantly increased 11-oxygenated androgens. Serum 11\u03b2-hydroxyandrostenedione and 11-ketoandrostenedione correlated significantly with markers of insulin resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We show that 11-oxygenated androgens represent the majority of circulating androgens in women with PCOS, with close correlation to markers of metabolic risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2016-3285","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T14:12:19Z","timestamp":1480515139000},"page":"840-848","source":"Crossref","is-referenced-by-count":240,"title":["11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"102","author":[{"given":"Michael W.","family":"O\u2019Reilly","sequence":"first","affiliation":[{"name":"Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom;"},{"name":"Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Edgbaston, Birmingham B15 2TH, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punith","family":"Kempegowda","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom;"},{"name":"Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Edgbaston, Birmingham B15 2TH, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom;"},{"name":"Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Edgbaston, Birmingham B15 2TH, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela E.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom;"},{"name":"Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Edgbaston, Birmingham B15 2TH, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Quanson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Storbeck","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Arlt","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom;"},{"name":"Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Edgbaston, Birmingham B15 2TH, United Kingdom;"},{"name":"National Institute of Health Research (NIHR) Birmingham Liver Biomedical Research Unit, University Hospital Birmingham, NHS Foundation Trust, Birmingham B15 2GW, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"issue":"1","key":"2020071619330570000_B1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome 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