{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:38:03Z","timestamp":1790818683236,"version":"4.1.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Central precocious puberty (CPP) results from premature activation of the hypothalamic\u2013pituitary\u2013gonadal axis. Few genetic causes of CPP have been identified, with the most common being mutations in the paternally expressed imprinted gene MKRN3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To identify the genetic etiology of CPP in a large multigenerational family.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Linkage analysis followed by whole-genome sequencing was performed in a family with five female members with nonsyndromic CPP. Detailed phenotyping was performed at the time of initial diagnosis and long-term follow-up, and circulating levels of Delta-like 1 homolog (DLK1) were measured in affected individuals. Expression of DLK1 was measured in mouse hypothalamus and in kisspeptin-secreting neuronal cell lines in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Endocrine clinic of an academic medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>Patients with familial CPP were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A complex defect of DLK1 (\u223c14-kb deletion and 269-bp duplication) was identified in this family. This deletion included the 5\u2032 untranslated region and the first exon of DLK1, including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1. The patients did not demonstrate additional features of the imprinted disorder Temple syndrome except for increased fat mass. Serum DLK1 levels were undetectable in all affected individuals. Dlk1 was expressed in mouse hypothalamus and in kisspeptin neuron-derived cell lines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We identified a genomic defect in DLK1 associated with isolated familial CPP. MKRN3 and DLK1 are both paternally expressed imprinted genes. These findings suggest a role of genomic imprinting in regulating the timing of human puberty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/jc.2016-3677","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T11:10:54Z","timestamp":1492600254000},"page":"1557-1567","source":"Crossref","is-referenced-by-count":201,"title":["Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty"],"prefix":"10.1210","volume":"102","author":[{"given":"Andrew","family":"Dauber","sequence":"first","affiliation":[{"name":"Cincinnati Center for Growth Disorders, Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Cunha-Silva","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-093, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delanie B.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-093, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius N.","family":"Brito","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-093, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Abreu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Boston Children\u2019s Hospital, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana R.","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-093, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Andrew","sequence":"additional","affiliation":[{"name":"Cincinnati Center for Growth Disorders, Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kirby","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Weirauch","sequence":"additional","affiliation":[{"name":"Center for Autoimmune Genomics and Etiology, Division of Biomedical Informatics and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Labilloy","sequence":"additional","affiliation":[{"name":"Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle S.","family":"Bessa","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-093, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona S.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakota C.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick E.","family":"Chappell","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice B.","family":"Mendonca","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-093, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Haig","sequence":"additional","affiliation":[{"name":"Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula B.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Latronico","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular\/LIM42, Hospital das Cl\u00ednicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-093, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"issue":"3","key":"2020071619153482500_B1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S2213-8587(15)00380-0","article-title":"Causes, diagnosis, and treatment of central precocious puberty","volume":"4","author":"Latronico","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"2020071619153482500_B2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S2213-8587(15)00418-0","article-title":"Pubertal development and regulation","volume":"4","author":"Abreu","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"7","key":"2020071619153482500_B3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa073443","article-title":"A GPR54-activating mutation in a patient with central precocious puberty","volume":"358","author":"Teles","year":"2008","journal-title":"N Engl J Med"},{"issue":"5","key":"2020071619153482500_B4","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1210\/jc.2009-2421","article-title":"Mutations of the KISS1 gene in disorders of puberty","volume":"95","author":"Silveira","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"26","key":"2020071619153482500_B5","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMoa1302160","article-title":"Central precocious puberty caused by mutations in the imprinted gene MKRN3","volume":"368","author":"Abreu","year":"2013","journal-title":"N Engl J Med"},{"issue":"4","key":"2020071619153482500_B6","doi-asserted-by":"crossref","first-page":"E647","DOI":"10.1210\/jc.2013-4084","article-title":"Central precocious puberty in a girl and early puberty in her brother caused by a novel mutation in the MKRN3 gene","volume":"99","author":"Settas","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2020071619153482500_B7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000362815","article-title":"MKRN3 mutations in familial central precocious puberty","volume":"82","author":"Schreiner","year":"2014","journal-title":"Horm Res Paediatr"},{"issue":"6","key":"2020071619153482500_B8","doi-asserted-by":"crossref","first-page":"E1097","DOI":"10.1210\/jc.2013-3126","article-title":"Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3","volume":"99","author":"Macedo","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2020071619153482500_B9","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1093\/humrep\/deu256","article-title":"A novel MKRN3 missense mutation causing familial precocious puberty","volume":"29","author":"de Vries","year":"2014","journal-title":"Hum Reprod"},{"issue":"1","key":"2020071619153482500_B10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-15-0488","article-title":"Mutations in the maternally imprinted gene MKRN3 are common in familial central precocious puberty","volume":"174","author":"Simon","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"7520","key":"2020071619153482500_B11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13545","article-title":"Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche","volume":"514","author":"Perry","year":"2014","journal-title":"Nature"},{"issue":"4","key":"2020071619153482500_B12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0092-8674(93)90252-L","article-title":"Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation","volume":"73","author":"Smas","year":"1993","journal-title":"Cell"},{"issue":"6","key":"2020071619153482500_B13","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1016\/S0021-9258(18)53544-4","article-title":"dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line","volume":"268","author":"Laborda","year":"1993","journal-title":"J Biol Chem"},{"issue":"4","key":"2020071619153482500_B14","doi-asserted-by":"crossref","first-page":"e36134","DOI":"10.1371\/journal.pone.0036134","article-title":"DLK1 is a somato-dendritic protein expressed in hypothalamic arginine-vasopressin and oxytocin neurons","volume":"7","author":"Villanueva","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"2020071619153482500_B15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/jne.12010","article-title":"Pituitary phenotypes of mice lacking the notch signalling ligand delta-like 1 homologue","volume":"25","author":"Cheung","year":"2013","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"2020071619153482500_B16","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1210\/jc.2003-030361","article-title":"Familial central precocious puberty suggests autosomal dominant inheritance","volume":"89","author":"de Vries","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2020071619153482500_B17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1046\/j.0300-0664.2001.01490.x","article-title":"Management and outcome of central precocious puberty","volume":"56","author":"Partsch","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"2020071619153482500_B18","doi-asserted-by":"crossref","first-page":"8399","DOI":"10.1007\/s13277-015-3607-8","article-title":"Serum DLK1 is a potential prognostic biomarker in patients with hepatocellular carcinoma","volume":"36","author":"Li","year":"2015","journal-title":"Tumour Biol"},{"issue":"3","key":"2020071619153482500_B19","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1177\/0300060513498669","article-title":"Detection of Delta-like 1 ligand for the diagnosis of tuberculous meningitis: an effective and rapid diagnostic method","volume":"42","author":"Peng","year":"2014","journal-title":"J Int Med Res"},{"issue":"9","key":"2020071619153482500_B20","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1210\/en.2016-1294","article-title":"Evaluation of immortalized AVPV- and arcuate-specific neuronal kisspeptin cell lines to elucidate potential mechanisms of estrogen responsiveness and temporal gene expression in females","volume":"157","author":"Jacobs","year":"2016","journal-title":"Endocrinology"},{"issue":"8","key":"2020071619153482500_B21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1136\/jmedgenet-2014-102396","article-title":"Temple syndrome: improving the recognition of an underdiagnosed chromosome 14 imprinting disorder: an analysis of 51 published cases","volume":"51","author":"Ioannides","year":"2014","journal-title":"J Med Genet"},{"issue":"28","key":"2020071619153482500_B22","doi-asserted-by":"crossref","first-page":"8696","DOI":"10.1073\/pnas.1504447112","article-title":"Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations","volume":"112","author":"Kehdy","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"16","key":"2020071619153482500_B23","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1101\/gad.14.16.1997","article-title":"The Dlk1 and Gtl2 genes are linked and reciprocally imprinted","volume":"14","author":"Schmidt","year":"2000","journal-title":"Genes Dev"},{"issue":"18","key":"2020071619153482500_B24","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0960-9822(00)00704-1","article-title":"Delta-like and Gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12","volume":"10","author":"Takada","year":"2000","journal-title":"Curr Biol"},{"issue":"11","key":"2020071619153482500_B25","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1101\/gr.161600","article-title":"Novel imprinted DLK1\/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2\/H19 regulation","volume":"10","author":"Wylie","year":"2000","journal-title":"Genome Res"},{"issue":"2","key":"2020071619153482500_B26","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1262\/jrd.18146","article-title":"Involvement of anteroventral periventricular metastin\/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats","volume":"53","author":"Adachi","year":"2007","journal-title":"J Reprod Dev"},{"issue":"1","key":"2020071619153482500_B27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/ajmg.a.37400","article-title":"Temple syndrome as a result of isolated hypomethylation of the 14q32 imprinted DLK1\/MEG3 region","volume":"170A","author":"Briggs","year":"2016","journal-title":"Am J Med Genet A"},{"issue":"8","key":"2020071619153482500_B28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1136\/jmg.28.8.511","article-title":"Maternal uniparental disomy for chromosome 14","volume":"28","author":"Temple","year":"1991","journal-title":"J Med Genet"},{"issue":"15","key":"2020071619153482500_B29","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1128\/MCB.22.15.5585-5592.2002","article-title":"Mice lacking paternally expressed Pref-1\/Dlk1 display growth retardation and accelerated adiposity","volume":"22","author":"Moon","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2020071619153482500_B30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ng.2007.56","article-title":"Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes","volume":"40","author":"Kagami","year":"2008","journal-title":"Nat Genet"},{"issue":"2","key":"2020071619153482500_B31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10059-011-1046-y","article-title":"Regulation of Notch1 signaling by Delta-like ligand 1 intracellular domain through physical interaction","volume":"32","author":"Jung","year":"2011","journal-title":"Mol Cells"},{"issue":"2","key":"2020071619153482500_B32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ydbio.2015.08.016","article-title":"Rbpj-\u03ba mediated Notch signaling plays a critical role in development of hypothalamic Kisspeptin neurons","volume":"406","author":"Biehl","year":"2015","journal-title":"Dev Biol"},{"issue":"6","key":"2020071619153482500_B33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ng.2968","article-title":"The noncoding RNA IPW regulates the imprinted DLK1-DIO3 locus in an induced pluripotent stem cell model of Prader-Willi syndrome","volume":"46","author":"Stelzer","year":"2014","journal-title":"Nat Genet"},{"key":"2020071619153482500_B34","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1146\/annurev.genet.37.110801.142741","article-title":"Genomic imprinting and kinship: how good is the evidence?","volume":"38","author":"Haig","year":"2004","journal-title":"Annu Rev Genet"},{"issue":"1711","key":"2020071619153482500_B35","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1098\/rspb.2010.2627","article-title":"The evolutionary biology of child health","volume":"278","author":"Crespi","year":"2011","journal-title":"Proc Biol Sci"},{"key":"2020071619153482500_B36","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1073\/pnas.0904111106","article-title":"Colloquium papers: transfers and transitions: parent-offspring conflict, genomic imprinting, and the evolution of human life history","volume":"107","author":"Haig","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2020071619153482500_B37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1542\/peds.42.1.210","article-title":"Head circumference in children with idiopathic hypopituitarism","volume":"42","author":"Nellhaus","year":"1968","journal-title":"Pediatrics"},{"issue":"13","key":"2020071619153482500_B38","first-page":"1","article-title":"Normal values for selected physical parameters: an aid to syndrome delineation","volume":"10","author":"Feingold","year":"1974","journal-title":"Birth Defects Orig Artic Ser"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/102\/5\/1557\/16630064\/jc.2016-3677.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/102\/5\/1557\/16630064\/jc.2016-3677.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T13:32:56Z","timestamp":1658928776000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/102\/5\/1557\/2960785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,27]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2016-3677","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,5,1]]},"published":{"date-parts":[[2017,1,27]]}}}