{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:14:13Z","timestamp":1792512853212,"version":"4.5.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1210\/jc.2016-3960","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T18:00:27Z","timestamp":1499364027000},"page":"2281-2290","source":"Crossref","is-referenced-by-count":112,"title":["Premature Ovarian Insufficiency: Phenotypic Characterization Within Different Etiologies"],"prefix":"10.1210","volume":"102","author":[{"given":"Xue","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanni","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangtao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,3,28]]},"reference":[{"issue":"4","key":"key\n\t\t\t\t20170706140016_B1","first-page":"604","article-title":"Incidence of premature ovarian failure","volume":"67","year":"1986","journal-title":"Obstet Gynecol"},{"issue":"9744","key":"key\n\t\t\t\t20170706140016_B2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(10)60355-8","article-title":"Primary ovarian insufficiency","volume":"376","year":"2010","journal-title":"Lancet"},{"issue":"1","key":"key\n\t\t\t\t20170706140016_B3","first-page":"20","article-title":"Effects of endocrine-disrupting chemicals on the ovary","volume":"93","year":"2015","journal-title":"Biol Reprod"},{"issue":"3","key":"key\n\t\t\t\t20170706140016_B4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00023.2015","article-title":"Physiological aspects of female fertility: role of the environment, modern lifestyle, and genetics","volume":"96","year":"2016","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170706140016_B5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1196\/annals.1429.019","article-title":"Genetic and phenotypic heterogeneity in ovarian failure: overview of selected candidate genes","volume":"1135","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"key\n\t\t\t\t20170706140016_B6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1210\/er.2016-1047","article-title":"Premature ovarian insufficiency: new perspectives on genetic cause and phenotypic spectrum","volume":"37","year":"2016","journal-title":"Endocr Rev"},{"issue":"6","key":"key\n\t\t\t\t20170706140016_B7","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1056\/NEJMcp0808697","article-title":"Clinical practice. Primary ovarian insufficiency","volume":"360","year":"2009","journal-title":"N Engl J Med"},{"issue":"7","key":"key\n\t\t\t\t20170706140016_B8","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/humrep\/des104","article-title":"Cytogenetic analysis of 531 Chinese women with premature ovarian failure","volume":"27","year":"2012","journal-title":"Hum Reprod"},{"issue":"7","key":"key\n\t\t\t\t20170706140016_B9","doi-asserted-by":"crossref","first-page":"e103316","DOI":"10.1371\/journal.pone.0103316","article-title":"FMR1 premutation is an uncommon explanation for premature ovarian failure in Han Chinese","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170706140016_B10","doi-asserted-by":"crossref","unstructured":"Qin Y, Jiao X, Dalgleish R, Vujovic S, Li J, Simpson JL, Al-Azzawi F, Chen ZJ. Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure. Fertil Steril. 2014;101(4):1104\u20131109.e6.","DOI":"10.1016\/j.fertnstert.2014.01.001"},{"issue":"9","key":"key\n\t\t\t\t20170706140016_B11","doi-asserted-by":"crossref","first-page":"e74759","DOI":"10.1371\/journal.pone.0074759","article-title":"Novel NR5A1 missense mutation in premature ovarian failure: detection in han chinese indicates causation in different ethnic groups","volume":"8","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"key\n\t\t\t\t20170706140016_B12","first-page":"360","article-title":"Geographic distribution and secular trend of menarche in 9-18 year-old Chinese Han girls","volume":"43","year":"2011","journal-title":"Beijing Da Xue Xue Bao"},{"issue":"2","key":"key\n\t\t\t\t20170706140016_B13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tem.2007.01.004","article-title":"Female reproductive ageing: current knowledge and future trends","volume":"18","year":"2007","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170706140016_B14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.maturitas.2004.01.013","article-title":"The age at menopause and associated factors at the health center area in Ankara, Turkey","volume":"49","year":"2004","journal-title":"Maturitas"},{"issue":"11","key":"key\n\t\t\t\t20170706140016_B15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0021-9681(87)90113-5","article-title":"Factors influencing the age at natural menopause","volume":"40","year":"1987","journal-title":"J Chronic Dis"},{"issue":"3","key":"key\n\t\t\t\t20170706140016_B16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.maturitas.2012.04.002","article-title":"Factors associated with premature ovarian failure, early menopause and earlier onset of menopause in Japanese women","volume":"72","year":"2012","journal-title":"Maturitas"},{"issue":"1","key":"key\n\t\t\t\t20170706140016_B17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13697130701878635","article-title":"Premature ovarian failure: a growing concern","volume":"11","year":"2008","journal-title":"Climacteric"},{"issue":"5 Pt 1","key":"key\n\t\t\t\t20170706140016_B18","first-page":"720","article-title":"Meeting the needs of young women with secondary amenorrhea and spontaneous premature ovarian failure","volume":"99","year":"2002","journal-title":"Obstet Gynecol"},{"issue":"5","key":"key\n\t\t\t\t20170706140016_B19","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.fertnstert.2006.04.028","article-title":"Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failure","volume":"86","year":"2006","journal-title":"Fertil Steril"},{"issue":"4","key":"key\n\t\t\t\t20170706140016_B20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/gme.0b013e3181cf8521","article-title":"Similar phenotype characteristics comparing familial and sporadic premature ovarian failure","volume":"17","author":"Dutch Premature Ovarian Failure Consortium","year":"2010","journal-title":"Menopause"},{"issue":"3","key":"key\n\t\t\t\t20170706140016_B21","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1210\/jc.2008-1818","article-title":"Anti-Mullerian hormone, inhibin B, and antral follicle count in young women with ovarian failure","volume":"94","author":"Dutch Premature Ovarian Failure Consortium","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170706140016_B22","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.fertnstert.2011.06.016","article-title":"Evaluation of serum antimullerian hormone and inhibin B concentrations in the differential diagnosis of secondary oligoamenorrhea","volume":"96","year":"2011","journal-title":"Fertil Steril"},{"issue":"8","key":"key\n\t\t\t\t20170706140016_B23","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1093\/humrep\/der174","article-title":"Idiopathic primary ovarian insufficiency: a study of serial hormonal profiles to assess ovarian follicular activity","volume":"26","year":"2011","journal-title":"Hum Reprod"},{"issue":"12","key":"key\n\t\t\t\t20170706140016_B24","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1210\/jc.2011-1038","article-title":"Resumption of ovarian function and pregnancies in 358 patients with premature ovarian failure","volume":"96","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"key\n\t\t\t\t20170706140016_B25","first-page":"89","article-title":"Idiopathic premature ovarian failure in 63 young women","volume":"65","year":"2006","journal-title":"Horm Res"},{"issue":"1","key":"key\n\t\t\t\t20170706140016_B26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/EJE-09-0231","article-title":"Phenotyping and genetic studies of 357 consecutive patients presenting with premature ovarian failure","volume":"161","author":"POF-GIS Study Group","year":"2009","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"key\n\t\t\t\t20170706140016_B27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/humupd\/dmv036","article-title":"Genetics of primary ovarian insufficiency: new developments and opportunities","volume":"21","year":"2015","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170706140016_B28","doi-asserted-by":"crossref","unstructured":"Baronchelli S, Conconi D, Panzeri E, Bentivegna A, Redaelli S, Lissoni S, Saccheri F, Villa N, Crosti F, Sala E, Martinoli E, Volonte M, Marozzi A, Dalpra L. Cytogenetics of premature ovarian failure: an investigation on 269 affected women. J Biomed Biotechnol. 2011:370195.","DOI":"10.1155\/2011\/370195"},{"issue":"6","key":"key\n\t\t\t\t20170706140016_B29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3109\/09513590.2013.788625","article-title":"Cytogenetic analysis of 179 Iranian women with premature ovarian failure","volume":"29","year":"2013","journal-title":"Gynecol Endocrinol"},{"issue":"2","key":"key\n\t\t\t\t20170706140016_B30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1399-0004.2009.01359.x","article-title":"Cytogenetic analyses of premature ovarian failure using karyotyping and interphase fluorescence in situ hybridization (FISH) in a group of 1000 patients","volume":"78","year":"2010","journal-title":"Clin Genet"},{"issue":"3","key":"key\n\t\t\t\t20170706140016_B31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2006.09.004","article-title":"The FMR1 premutation and reproduction","volume":"87","year":"2007","journal-title":"Fertil Steril"},{"issue":"4","key":"key\n\t\t\t\t20170706140016_B32","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1097\/AOG.0b013e3181fae884","article-title":"ACOG Committee Opinion No. 469: Carrier screening for fragile X syndrome","volume":"116","author":"American College of Obstetricians and Gynecologists Committee on Genetics","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"5","key":"key\n\t\t\t\t20170706140016_B33","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/humrep\/dew027","article-title":"ESHRE Guideline: management of women with premature ovarian insufficiency","volume":"31","author":"European Society for Human Reproduction and Embryology (ESHRE) Guideline Group on POI","year":"2016","journal-title":"Hum Reprod"},{"issue":"4-5","key":"key\n\t\t\t\t20170706140016_B34","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.autrev.2014.01.003","article-title":"Autoimmune primary ovarian insufficiency","volume":"13","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"4","key":"key\n\t\t\t\t20170706140016_B35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jaut.2012.01.015","article-title":"Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency","volume":"38","year":"2012","journal-title":"J Autoimmun"},{"issue":"2","key":"key\n\t\t\t\t20170706140016_B36","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0015-0282(02)03205-3","article-title":"Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity","volume":"78","year":"2002","journal-title":"Fertil Steril"},{"issue":"4","key":"key\n\t\t\t\t20170706140016_B37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/GCO.0b013e32833b6c70","article-title":"Primary ovarian insufficiency: autoimmune causes","volume":"22","year":"2010","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"10","key":"key\n\t\t\t\t20170706140016_B38","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/humrep\/deu199","article-title":"The effect of surgery for endometrioma on ovarian reserve evaluated by antral follicle count: a systematic review and meta-analysis","volume":"29","year":"2014","journal-title":"Hum Reprod"},{"issue":"5","key":"key\n\t\t\t\t20170706140016_B39","doi-asserted-by":"crossref","first-page":"e98174","DOI":"10.1371\/journal.pone.0098174","article-title":"Analysis of late-onset ovarian insufficiency after ovarian surgery: retrospective study with 75 patients of post-surgical ovarian insufficiency","volume":"9","year":"2014","journal-title":"PLoS One"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/102\/7\/2281\/18171372\/jc.2016-3960.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T12:50:08Z","timestamp":1750510208000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article-lookup\/doi\/10.1210\/jc.2016-3960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,28]]},"references-count":39,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,3,28]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2016-3960","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,28]]}}}