{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:30:08Z","timestamp":1788877808247,"version":"build-2803163510"},"reference-count":52,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"DOI":"10.1210\/jc.2016-3989","type":"journal-article","created":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T14:02:35Z","timestamp":1493647355000},"page":"2701-2710","source":"Crossref","is-referenced-by-count":103,"title":["11-Oxygenated Androgens Are Biomarkers of Adrenal Volume and Testicular Adrenal Rest Tumors in 21-Hydroxylase Deficiency"],"prefix":"10.1210","volume":"102","author":[{"given":"Adina F","family":"Turcu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Mallappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith S","family":"Elman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilo A","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Marko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamsini","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tsodikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Auchus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah P","family":"Merke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,5,1]]},"reference":[{"issue":"8","key":"key\n\t\t\t\t20170807135909_B1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1056\/NEJMra021561","article-title":"Congenital adrenal hyperplasia","volume":"349","year":"2003","journal-title":"N Engl J Med"},{"issue":"9477","key":"key\n\t\t\t\t20170807135909_B2","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/S0140-6736(05)66736-0","article-title":"Congenital adrenal hyperplasia","volume":"365","year":"2005","journal-title":"Lancet"},{"issue":"5","key":"key\n\t\t\t\t20170807135909_B3","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1210\/jc.2009-1929","article-title":"Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170807135909_B4","first-page":"685","article-title":"Adrenal incidentaloma and patients with homozygous or heterozygous congenital adrenal hyperplasia","volume":"74","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"key\n\t\t\t\t20170807135909_B5","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1365-2265.2011.04151.x","article-title":"High frequency of adrenal myelolipomas and testicular adrenal rest tumours in adult Norwegian patients with classical congenital adrenal hyperplasia because of 21-hydroxylase deficiency","volume":"75","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"key\n\t\t\t\t20170807135909_B6","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1210\/jcem.86.12.8090","article-title":"High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia","volume":"86","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170807135909_B7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1530\/EJE-07-0201","article-title":"Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"157","year":"2007","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"key\n\t\t\t\t20170807135909_B8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1530\/EJE-11-0828","article-title":"Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia","volume":"166","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"key\n\t\t\t\t20170807135909_B9","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1210\/jc.2014-4124","article-title":"Clinical outcome, hormonal status, gonadotrope axis, and testicular function in 219 adult men born with classic 21-hydroxylase deficiency. A French national survey","volume":"100","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170807135909_B10","doi-asserted-by":"crossref","first-page":"383","DOI":"10.7863\/jum.2012.31.3.383","article-title":"Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia: prevalence and sonographic, hormonal, and seminal characteristics","volume":"31","year":"2012","journal-title":"J Ultrasound Med"},{"issue":"4","key":"key\n\t\t\t\t20170807135909_B11","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.4158\/EP13092.CR","article-title":"Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy","volume":"20","year":"2014","journal-title":"Endocr Pract"},{"issue":"3","key":"key\n\t\t\t\t20170807135909_B12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000295722","article-title":"Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following adrenalectomy","volume":"74","year":"2010","journal-title":"Horm Res Paediatr"},{"issue":"10","key":"key\n\t\t\t\t20170807135909_B13","first-page":"1802","article-title":"Prevalence of ovarian adrenal rest tumours and polycystic ovaries in females with congenital adrenal hyperplasia: results of ultrasonography and MR imaging","volume":"14","year":"2004","journal-title":"Eur Radiol"},{"issue":"11","key":"key\n\t\t\t\t20170807135909_B14","doi-asserted-by":"crossref","first-page":"E2084","DOI":"10.1210\/jc.2012-2298","article-title":"Use of PET\/CT with cosyntropin stimulation to identify and localize adrenal rest tissue following adrenalectomy in a woman with congenital adrenal hyperplasia","volume":"97","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"key\n\t\t\t\t20170807135909_B15","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/jc.2009-2631","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline","volume":"95","author":"Endocrine Society","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"key\n\t\t\t\t20170807135909_B16","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1530\/EJE-15-1181","article-title":"Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency","volume":"174","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"key\n\t\t\t\t20170807135909_B17","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1210\/jc.2015-1023","article-title":"Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency","volume":"100","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170807135909_B18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jsbmb.2016.08.006","article-title":"The urinary steroidome of treated children with classic 21-hydroxylase deficiency","volume":"165","year":"2017","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"12","key":"key\n\t\t\t\t20170807135909_B19","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1210\/jc.2012-2102","article-title":"Clinical characteristics of a cohort of 244 patients with congenital adrenal hyperplasia","volume":"97","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"key\n\t\t\t\t20170807135909_B20","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1210\/jc.2002-020590","article-title":"Pubertal and gender-related changes in the sympathoadrenal system in healthy children","volume":"87","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"key\n\t\t\t\t20170807135909_B21","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1210\/jc.2016-1916","article-title":"A phase 2 study of continuous subcutaneous hydrocortisone infusion in adults with congenital adrenal hyperplasia","volume":"101","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"31","key":"key\n\t\t\t\t20170807135909_B22","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1021\/acs.biochem.6b00532","article-title":"Cytochrome b5 activates the 17,20-lyase activity of human cytochrome P450 17A1 by increasing the coupling of NADPH consumption to androgen production","volume":"55","year":"2016","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170807135909_B23","volume-title":"Radiographic Skeletal Development of the Hand and Wrist","year":"1985"},{"issue":"4","key":"key\n\t\t\t\t20170807135909_B24","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1055\/s-0042-103686","article-title":"Use of 3-dimensional volumetric modeling of adrenal gland size in patients with primary pigmented nodular adrenocortical disease","volume":"48","year":"2016","journal-title":"Horm Metab Res"},{"issue":"4","key":"key\n\t\t\t\t20170807135909_B25","first-page":"482","article-title":"Normal organ volume assessment from abdominal CT","volume":"29","year":"2004","journal-title":"Abdom Imaging"},{"issue":"6","key":"key\n\t\t\t\t20170807135909_B26","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1365-2265.2010.03871.x","article-title":"Superior discriminating value of ACTH-stimulated serum 21-deoxycortisol in identifying heterozygote carriers for 21-hydroxylase deficiency","volume":"73","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2-4","key":"key\n\t\t\t\t20170807135909_B27","first-page":"95","article-title":"Diagnosis of congenital adrenal hyperplasia based on plasma 21-deoxycortisol level determined with a specific radioimmunoassay","volume":"16","year":"1984","journal-title":"Mater Med Pol"},{"issue":"3","key":"key\n\t\t\t\t20170807135909_B28","doi-asserted-by":"crossref","first-page":"E518","DOI":"10.1210\/jc.2013-3198","article-title":"Transcriptome profiling reveals differentially expressed transcripts between the human adrenal zona fasciculata and zona reticularis","volume":"99","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170807135909_B29","doi-asserted-by":"crossref","first-page":"E367","DOI":"10.1210\/jc.2011-1997","article-title":"Increased activation of the alternative \u201cbackdoor\u201d pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis","volume":"97","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"key\n\t\t\t\t20170807135909_B30","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1210\/jc.2007-0337","article-title":"Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue","volume":"92","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"key\n\t\t\t\t20170807135909_B31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jsbmb.2004.10.023","article-title":"Testicular adrenal rest tumours in salt wasting congenital adrenal hyperplasia (in vivo and in vitro studies)","volume":"93","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"key\n\t\t\t\t20170807135909_B32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1210\/jcem-53-1-85","article-title":"Cortisol production by testicular tumors in a patient with congenital adrenal hyperplasia (21-hydroxylase deficiency)","volume":"53","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"key\n\t\t\t\t20170807135909_B33","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1210\/jcem-70-5-1408","article-title":"Steroidogenic enzyme activities, morphology, and receptor studies of a testicular adrenal rest in a patient with congenital adrenal hyperplasia","volume":"70","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"key\n\t\t\t\t20170807135909_B34","first-page":"645","article-title":"Asymptomatic testicular adrenal rest tumours in adolescent and adult males with congenital adrenal hyperplasia: basal and follow-up investigation after 2.6 years","volume":"17","year":"2004","journal-title":"J Pediatr Endocrinol Metab"},{"key":"key\n\t\t\t\t20170807135909_B35","first-page":"705e5","article-title":"Repeated successful induction of fertility after replacing hydrocortisone with dexamethasone in a patient with congenital adrenal hyperplasia and testicular adrenal rest tumors","volume-title":"Fertil Steril","year":"2007"},{"key":"key\n\t\t\t\t20170807135909_B36","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jcem-23-9-861","article-title":"Activation of testicular adrenal rest tissue by prolonged excessive ACTH production","volume":"23","year":"1963","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"key\n\t\t\t\t20170807135909_B37","first-page":"3070","article-title":"Long term outcome in adult males with classic congenital adrenal hyperplasia","volume":"86","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"key\n\t\t\t\t20170807135909_B38","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0022-5347(01)65023-7","article-title":"Testis sparing surgery for steroid unresponsive testicular tumors of the adrenogenital syndrome","volume":"157","year":"1997","journal-title":"J Urol"},{"issue":"2","key":"key\n\t\t\t\t20170807135909_B39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.beem.2008.09.007","article-title":"Testicular adrenal rest tumours in congenital adrenal hyperplasia","volume":"23","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170807135909_B40","doi-asserted-by":"crossref","first-page":"E524","DOI":"10.1210\/jc.2014-2036","article-title":"Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features","volume":"100","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"key\n\t\t\t\t20170807135909_B41","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1365-2559.1991.tb00239.x","article-title":"The testicular \u2018tumour\u2019 of adrenogenital syndrome--a persistent diagnostic pitfall","volume":"19","year":"1991","journal-title":"Histopathology"},{"issue":"11","key":"key\n\t\t\t\t20170807135909_B42","doi-asserted-by":"crossref","first-page":"E1820","DOI":"10.1210\/jc.2012-3181","article-title":"Testicular adrenal rest tumors develop independently of long-term disease control: a longitudinal analysis of 50 adult men with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency","volume":"98","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170807135909_B43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1001\/archpedi.1963.02080050245001","article-title":"Testicular hilar nodules in adrenogenital syndrome. The nature of the nodules","volume":"106","year":"1963","journal-title":"Am J Dis Child"},{"issue":"2","key":"key\n\t\t\t\t20170807135909_B44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000316531","article-title":"Prevalence of testicular adrenal rest tissue in neonates","volume":"75","year":"2011","journal-title":"Horm Res Paediatr"},{"issue":"2","key":"key\n\t\t\t\t20170807135909_B45","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1136\/adc.87.2.139","article-title":"Longitudinal analysis of growth and puberty in 21-hydroxylase deficiency patients","volume":"87","year":"2002","journal-title":"Arch Dis Child"},{"issue":"4","key":"key\n\t\t\t\t20170807135909_B46","first-page":"161","article-title":"Growth patterns and final height in congenital adrenal hyperplasia due to classical 21-hydroxylase deficiency. Results of a multicenter study","volume":"55","author":"MEWPE-CAH Study Group","year":"2001","journal-title":"Horm Res"},{"issue":"2","key":"key\n\t\t\t\t20170807135909_B47","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1590\/S0004-27302013000200005","article-title":"Final height in congenital adrenal hyperplasia: the dilemma of hypercortisolism versus hyperandrogenism","volume":"57","year":"2013","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"9","key":"key\n\t\t\t\t20170807135909_B48","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1210\/jc.2009-2616","article-title":"Clinical review: Adult height in patients with congenital adrenal hyperplasia: a systematic review and metaanalysis","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"key\n\t\t\t\t20170807135909_B49","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1210\/jc.2016-2311","article-title":"11-ketotestosterone is a major androgen produced in human gonads","volume":"101","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170807135909_B50","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1210\/jc.2012-2912","article-title":"Liquid chromatography-tandem mass spectrometry analysis of human adrenal vein 19-carbon steroids before and after ACTH stimulation","volume":"98","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170807135909_B51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jsbmb.2015.11.005","article-title":"Development of a novel cell based androgen screening model","volume":"156","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1-2","key":"key\n\t\t\t\t20170807135909_B52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mce.2013.07.006","article-title":"11\u03b2-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?","volume":"377","year":"2013","journal-title":"Mol Cell Endocrinol"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/102\/8\/2701\/19452594\/jc.2016-3989.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T15:22:10Z","timestamp":1503588130000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/jcem\/article\/102\/8\/2701\/3784584\/11Oxygenated-Androgens-Are-Biomarkers-of-Adrenal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,1]]},"references-count":52,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,5,1]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2016-3989","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,1]]}}}