{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:45:25Z","timestamp":1768808725999,"version":"3.49.0"},"reference-count":25,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"DOI":"10.1210\/jc.2017-00056","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T14:11:33Z","timestamp":1493820693000},"page":"2660-2669","source":"Crossref","is-referenced-by-count":48,"title":["Fibronectin Type III Domain\u2013Containing Protein 5 rs3480 A&gt;G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease"],"prefix":"10.1210","volume":"102","author":[{"given":"Salvatore","family":"Petta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Valenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Svegliati-Baroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Ruscica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria Maria","family":"Pipitone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Dongiovanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Rychlicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calogero","family":"Camm\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Ludovica","family":"Fracanzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Pierantonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Di Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marica","family":"Meroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Grimaudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Maggioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Cabibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Fargion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Crax\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"issue":"12","key":"key\n\t\t\t\t20170807135929_B1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.dld.2015.08.004","article-title":"Epidemiological modifiers of non-alcoholic fatty liver disease: focus on high-risk groups","volume":"47","author":"Non-Alcoholic Fatty Liver Disease Study Group","year":"2015","journal-title":"Dig Liver Dis"},{"issue":"1","key":"key\n\t\t\t\t20170807135929_B2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2013.08.011","article-title":"Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team","volume":"60","year":"2014","journal-title":"J Hepatol"},{"issue":"3","key":"key\n\t\t\t\t20170807135929_B3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1053\/j.gastro.2014.11.039","article-title":"Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States","volume":"148","year":"2015","journal-title":"Gastroenterology"},{"issue":"5","key":"key\n\t\t\t\t20170807135929_B4","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/hep.27368","article-title":"Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up","volume":"61","year":"2015","journal-title":"Hepatology"},{"issue":"2","key":"key\n\t\t\t\t20170807135929_B5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease","volume":"149","year":"2015","journal-title":"Gastroenterology"},{"issue":"3","key":"key\n\t\t\t\t20170807135929_B6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/j.gastro.2014.06.043","article-title":"Roles for chemokines in liver disease","volume":"147","year":"2014","journal-title":"Gastroenterology"},{"issue":"9","key":"key\n\t\t\t\t20170807135929_B7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.dld.2009.01.004","article-title":"Non-alcoholic fatty liver disease pathogenesis: the present and the future","volume":"41","year":"2009","journal-title":"Dig Liver Dis"},{"issue":"39","key":"key\n\t\t\t\t20170807135929_B8","doi-asserted-by":"crossref","first-page":"11088","DOI":"10.3748\/wjg.v21.i39.11088","article-title":"Genetic background in nonalcoholic fatty liver disease: a comprehensive review","volume":"21","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"3","key":"key\n\t\t\t\t20170807135929_B9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cmet.2012.02.010","article-title":"Irisin, turning up the heat","volume":"15","year":"2012","journal-title":"Cell Metab"},{"issue":"3","key":"key\n\t\t\t\t20170807135929_B10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jhep.2013.04.030","article-title":"Irisin is inversely associated with intrahepatic triglyceride contents in obese adults","volume":"59","year":"2013","journal-title":"J Hepatol"},{"issue":"10","key":"key\n\t\t\t\t20170807135929_B11","doi-asserted-by":"crossref","first-page":"e110680","DOI":"10.1371\/journal.pone.0110680","article-title":"Association between serum irisin levels and non-alcoholic fatty liver disease in health screen examinees","volume":"9","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"key\n\t\t\t\t20170807135929_B12","doi-asserted-by":"crossref","first-page":"e61903","DOI":"10.1371\/journal.pone.0061903","article-title":"Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived \u201cbrowning\u201d factor irisin, determines insulin sensitivity","volume":"8","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"key\n\t\t\t\t20170807135929_B13","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.cellsig.2015.04.010","article-title":"New role of irisin in hepatocytes: the protective effect of hepatic steatosis in vitro","volume":"27","year":"2015","journal-title":"Cell Signal"},{"issue":"5","key":"key\n\t\t\t\t20170807135929_B14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1210\/me.2015-1292","article-title":"Irisin is regulated by CAR in liver and is a mediator of hepatic glucose and lipid metabolism","volume":"30","year":"2016","journal-title":"Mol Endocrinol"},{"issue":"6","key":"key\n\t\t\t\t20170807135929_B15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Nonalcoholic Steatohepatitis Clinical Research Network","year":"2005","journal-title":"Hepatology"},{"issue":"3","key":"key\n\t\t\t\t20170807135929_B16","doi-asserted-by":"crossref","first-page":"846","DOI":"10.2353\/ajpath.2006.050953","article-title":"A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury","volume":"169","year":"2006","journal-title":"Am J Pathol"},{"issue":"3","key":"key\n\t\t\t\t20170807135929_B17","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.ajpath.2013.05.030","article-title":"Semaphorin 7A contributes to TGF-\u03b2-mediated liver fibrogenesis","volume":"183","year":"2013","journal-title":"Am J Pathol"},{"issue":"2","key":"key\n\t\t\t\t20170807135929_B18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.metabol.2013.09.013","article-title":"Irisin in patients with nonalcoholic fatty liver disease","volume":"63","year":"2014","journal-title":"Metabolism"},{"issue":"4","key":"key\n\t\t\t\t20170807135929_B19","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.metabol.2014.01.005","article-title":"Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels","volume":"63","year":"2014","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20170807135929_B20","doi-asserted-by":"crossref","first-page":"29898","DOI":"10.1038\/srep29898","article-title":"FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle","volume":"6","year":"2016","journal-title":"Sci Rep"},{"issue":"12","key":"key\n\t\t\t\t20170807135929_B21","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","year":"2008","journal-title":"Nat Genet"},{"issue":"3","key":"key\n\t\t\t\t20170807135929_B22","doi-asserted-by":"crossref","first-page":"e1001324","DOI":"10.1371\/journal.pgen.1001324","article-title":"Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits","volume":"7","author":"NASH CRN","year":"2011","journal-title":"PLoS Genet"},{"issue":"4","key":"key\n\t\t\t\t20170807135929_B23","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng.2901","article-title":"Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease","volume":"46","year":"2014","journal-title":"Nat Genet"},{"issue":"4","key":"key\n\t\t\t\t20170807135929_B24","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/hep.23622","article-title":"Homozygosity for the patatin-like phospholipase-3\/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease","volume":"51","year":"2010","journal-title":"Hepatology"},{"issue":"3","key":"key\n\t\t\t\t20170807135929_B25","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jhep.2015.10.016","article-title":"MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease","volume":"64","year":"2016","journal-title":"J Hepatol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/102\/8\/2660\/19452630\/jc.2017-00056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T15:23:42Z","timestamp":1503588222000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/jcem\/article\/102\/8\/2660\/3788879\/Fibronectin-Type-III-DomainContaining-Protein-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":25,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,5,3]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-00056","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,3]]}}}