{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:05:57Z","timestamp":1781622357162,"version":"3.54.5"},"reference-count":40,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context:<\/jats:title>\n                  <jats:p>Carotenoids have been implicated in the regulation of adipocyte metabolism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To compare the effects of mixed-carotenoid supplementation (MCS) versus placebo on adipokines and the accrual of abdominal adiposity in children with obesity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Setting:<\/jats:title>\n                  <jats:p>Randomized (1:1), double-blind, placebo-controlled intervention trial to evaluate the effects of MCS over 6 months in a subspecialty clinic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants:<\/jats:title>\n                  <jats:p>Twenty (6 male and 14 female) children with simple obesity [body mass index (BMI) &amp;gt; 90%], a mean age (\u00b1 standard deviation) of 10.5 \u00b1 0.4 years, and Tanner stage I to V were enrolled; 17 participants completed the trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention:<\/jats:title>\n                  <jats:p>MCS (which contains \u03b2-carotene, \u03b1-carotene, lutein, zeaxanthin, lycopene, astaxanthin, and \u03b3-tocopherol) or placebo was administered daily.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures:<\/jats:title>\n                  <jats:p>Primary outcomes were change in \u03b2-carotene, abdominal fat accrual (according to magnetic resonance imaging), and BMI z-score; secondary outcomes were adipokines and markers of insulin resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Cross-sectional analysis of \u03b2-carotene showed inverse correlation with BMI z-score, waist-to-height ratio, visceral adipose tissue, and subcutaneous adipose tissue (SAT) at baseline. MCS increased \u03b2-carotene, total adiponectin, and high-molecular-weight adiponectin compared with placebo. MCS led to a greater reduction in BMI z-score, waist-to-height ratio, and SAT compared with placebo. The percentage change in \u03b2-carotene directly correlated with the percentage change in SAT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The decrease in BMI z-score, waist-to-height ratio, and SAT and the concomitant increase in the concentration of \u03b2-carotene and high-molecular-weight adiponectin by MCS suggest the putative beneficial role of MCS in children with obesity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2017-00185","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T15:11:21Z","timestamp":1492614681000},"page":"1983-1990","source":"Crossref","is-referenced-by-count":76,"title":["Effects of Mixed Carotenoids on Adipokines and Abdominal Adiposity in Children: A Pilot Study"],"prefix":"10.1210","volume":"102","author":[{"given":"J. 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