{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:02:28Z","timestamp":1775181748845,"version":"3.50.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"DOI":"10.1210\/jc.2017-00272","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T15:09:54Z","timestamp":1492614594000},"page":"2000-2008","source":"Crossref","is-referenced-by-count":23,"title":["Early Pregnancy-Associated Plasma Protein A Concentrations Are Associated With Third Trimester Insulin Sensitivity"],"prefix":"10.1210","volume":"102","author":[{"given":"Clive J.","family":"Petry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken K.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ieuan A.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo L.","family":"Acerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Dunger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"issue":"2","key":"key\n\t\t\t\t20170606140055_B1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0002-9378(74)90553-5","article-title":"Characterization of four human pregnancy-associated plasma proteins","volume":"118","year":"1974","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"key\n\t\t\t\t20170606140055_B2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12079-015-0259-9","article-title":"The role of PAPP-A in the IGF system: location, location, location","volume":"9","year":"2015","journal-title":"J Cell Commun Signal"},{"issue":"1","key":"key\n\t\t\t\t20170606140055_B3","first-page":"77","article-title":"Pregnancy-associated plasma protein-A is involved in insulin-like growth factor binding protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine preovulatory follicles: identification of cleavage site and characterization of IGFBP-2 degradation","volume":"68","year":"2003","journal-title":"Biol Reprod"},{"issue":"1-2","key":"key\n\t\t\t\t20170606140055_B4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0014-5793(01)02760-0","article-title":"Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A","volume":"504","year":"2001","journal-title":"FEBS Lett"},{"issue":"5","key":"key\n\t\t\t\t20170606140055_B5","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1373\/clinchem.2006.080614","article-title":"Quantification of proteolytically active pregnancy-associated plasma protein-A with an assay based on quenched fluorescence","volume":"53","year":"2007","journal-title":"Clin Chem"},{"issue":"5","key":"key\n\t\t\t\t20170606140055_B6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tem.2012.02.008","article-title":"Key questions and answers about pregnancy-associated plasma protein-A","volume":"23","year":"2012","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"key\n\t\t\t\t20170606140055_B7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/bdrb.20249","article-title":"Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development","volume":"89","year":"2010","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"issue":"1","key":"key\n\t\t\t\t20170606140055_B8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/uog.14870","article-title":"Serum pregnancy-associated plasma protein-A in the three trimesters of pregnancy: effects of maternal characteristics and medical history","volume":"46","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"4","key":"key\n\t\t\t\t20170606140055_B9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/aji.12270","article-title":"Temporal variation in soluble human leukocyte antigen-G (sHLA-G) and pregnancy-associated plasma protein A (PAPP-A) in pregnancies complicated by gestational diabetes mellitus and in controls","volume":"72","year":"2014","journal-title":"Am J Reprod Immunol"},{"issue":"11","key":"key\n\t\t\t\t20170606140055_B10","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.3109\/14767058.2012.684170","article-title":"Association between pregnancy-associated plasma protein-A and gestational diabetes requiring insulin treatment at 11-14 weeks of gestation","volume":"25","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"key\n\t\t\t\t20170606140055_B11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/09513590.2012.708800","article-title":"Can first-trimester screening program detect women at high risk for gestational diabetes mellitus?","volume":"29","year":"2013","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"key\n\t\t\t\t20170606140055_B12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.diabres.2013.04.002","article-title":"Gestational diabetes mellitus: including serum pregnancy-associated plasma protein-A testing in the clinical management of primiparous women? A case-control study","volume":"100","year":"2013","journal-title":"Diabetes Res Clin Pract"},{"issue":"10","key":"key\n\t\t\t\t20170606140055_B13","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1471-0528.2000.tb11618.x","article-title":"First trimester maternal serum free \u03b2 human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications","volume":"107","year":"2000","journal-title":"BJOG"},{"issue":"Pt 6","key":"key\n\t\t\t\t20170606140055_B14","first-page":"603","article-title":"The association between gestational diabetes mellitus and first trimester aneuploidy screening markers","volume":"50","year":"2013","journal-title":"Ann Clin Biochem"},{"issue":"11","key":"key\n\t\t\t\t20170606140055_B15","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.metabol.2015.07.015","article-title":"First-trimester biochemical markers of placentation in screening for gestational diabetes mellitus","volume":"64","year":"2015","journal-title":"Metabolism"},{"issue":"6","key":"key\n\t\t\t\t20170606140055_B16","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1210\/jc.2014-4103","article-title":"Maternal diabetes, large-for-gestational-age births, and first trimester pregnancy-associated plasma protein-A","volume":"100","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"key\n\t\t\t\t20170606140055_B17","first-page":"30","article-title":"Association between pregnancy-associated plasma protein-A levels in the first trimester and gestational diabetes mellitus in Chinese women","volume":"22","year":"2016","journal-title":"Hong Kong Med J"},{"issue":"2","key":"key\n\t\t\t\t20170606140055_B18","first-page":"225","article-title":"Association of first trimester low PAPP-A levels with adverse pregnancy outcomes","volume":"39","year":"2012","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"3","key":"key\n\t\t\t\t20170606140055_B19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3109\/10641955.2016.1161766","article-title":"Role of maternal factors, PAPP-A, and Doppler in screening for early- and late-onset pregnancy hypertension in Asian population","volume":"35","year":"2016","journal-title":"Hypertens Pregnancy"},{"issue":"4","key":"key\n\t\t\t\t20170606140055_B20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.placenta.2011.01.016","article-title":"First-trimester serum analytes, biophysical tests and the association with pathological morphometry in the placenta of pregnancies with preeclampsia and fetal growth restriction","volume":"32","year":"2011","journal-title":"Placenta"},{"issue":"1","key":"key\n\t\t\t\t20170606140055_B21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/uog.6280","article-title":"First-trimester maternal serum pregnancy-associated plasma protein-A and pre-eclampsia","volume":"33","year":"2009","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"key\n\t\t\t\t20170606140055_B22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fertnstert.2007.02.024","article-title":"Association between birth weight and first-trimester free \u03b2\u2013human chorionic gonadotropin and pregnancy-associated plasma protein A","volume":"89","year":"2008","journal-title":"Fertil Steril"},{"issue":"3","key":"key\n\t\t\t\t20170606140055_B23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1515\/jpm-2014-0041","article-title":"Incorporating first trimester analytes to predict delivery of a large for gestational infant in women with impaired glucose tolerance","volume":"43","year":"2015","journal-title":"J Perinat Med"},{"issue":"16","key":"key\n\t\t\t\t20170606140055_B24","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3109\/14767058.2013.794779","article-title":"First and second trimester screening for large for gestational age infants","volume":"26","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"1","key":"key\n\t\t\t\t20170606140055_B25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3109\/14767058.2013.799658","article-title":"First trimester maternal lipid levels and serum markers of small- and large-for-gestational age infants","volume":"27","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"9","key":"key\n\t\t\t\t20170606140055_B26","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/pd.2578","article-title":"The relationship between first trimester fetal growth, pregnancy-associated plasma protein A levels and birthweight","volume":"30","year":"2010","journal-title":"Prenat Diagn"},{"issue":"1","key":"key\n\t\t\t\t20170606140055_B27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/uog.5206","article-title":"Prediction of birth weight by fetal crown-rump length and maternal serum levels of pregnancy-associated plasma protein-A in the first trimester","volume":"31","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"key\n\t\t\t\t20170606140055_B28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4236\/ojog.2015.56053","article-title":"Maternal PAPP-A levels at 11\u201313 weeks of gestation predict foetal and neonatal growth","volume":"5","year":"2015","journal-title":"Open J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170606140055_B29","first-page":"581","article-title":"First trimester maternal serum PAPP-A levels and macrosomia in nondiabetic mothers","volume":"41","year":"2011","journal-title":"Turk J Med Sci"},{"issue":"6","key":"key\n\t\t\t\t20170606140055_B30","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1161\/HYPERTENSIONAHA.116.08261","article-title":"Associations between fetal imprinted genes and maternal blood pressure in pregnancy","volume":"68","year":"2016","journal-title":"Hypertension"},{"issue":"3","key":"key\n\t\t\t\t20170606140055_B31","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/dc09-1848","article-title":"International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"International Association of Diabetes and Pregnancy Study Groups Consensus Panel","year":"2010","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20170606140055_B32","unstructured":"National Institute for Health and Care Excellence. Hypertension in pregnancy: diagnosis and management. NICE guideline [CG107]. Available at: http:\/\/www.nice.org.uk\/guidance\/cg107. Accessed 28 July 2016."},{"issue":"6","key":"key\n\t\t\t\t20170606140055_B33","doi-asserted-by":"crossref","first-page":"E1149","DOI":"10.1152\/ajpendo.00410.2002","article-title":"A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum","volume":"284","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11","key":"key\n\t\t\t\t20170606140055_B34","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2337\/dc08-1111","article-title":"Pregnancy insulin, glucose, and BMI contribute to birth outcomes in nondiabetic mothers","volume":"31","year":"2008","journal-title":"Diabetes Care"},{"issue":"7","key":"key\n\t\t\t\t20170606140055_B35","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1210\/jcem.82.7.4070","article-title":"Free insulin-like growth factor I (IGF-I) in healthy subjects: relationship with IGF-binding proteins and insulin sensitivity","volume":"82","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"key\n\t\t\t\t20170606140055_B36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2337\/diacare.28.1.120","article-title":"Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance","volume":"28","year":"2005","journal-title":"Diabetes Care"},{"issue":"2","key":"key\n\t\t\t\t20170606140055_B37","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2337\/dc09-1196","article-title":"Hormonal and metabolic factors associated with variations in insulin sensitivity in human pregnancy","volume":"33","author":"Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cooperative Research Group","year":"2010","journal-title":"Diabetes Care"},{"issue":"11","key":"key\n\t\t\t\t20170606140055_B38","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.2337\/db16-0514","article-title":"Insulin-like growth factor axis and gestational diabetes mellitus: a longitudinal study in a multiracial cohort","volume":"65","year":"2016","journal-title":"Diabetes"},{"issue":"2","key":"key\n\t\t\t\t20170606140055_B39","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2478\/v10039-011-0046-7","article-title":"Increased serum insulin-like growth factor-1 levels in women with gestational diabetes","volume":"56","year":"2011","journal-title":"Adv Med Sci"},{"issue":"3","key":"key\n\t\t\t\t20170606140055_B40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/157339909788920947","article-title":"Placental growth hormone, fetal growth and the IGF axis in normal and diabetic pregnancy","volume":"5","year":"2009","journal-title":"Curr Diabetes Rev"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/102\/6\/2000\/17665262\/jc.2017-00272.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T05:45:47Z","timestamp":1692769547000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article-lookup\/doi\/10.1210\/jc.2017-00272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,13]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,3,13]]},"published-print":{"date-parts":[[2017,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-00272","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,13]]}}}