{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:49:59Z","timestamp":1790470199955,"version":"4.1.0"},"reference-count":32,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"DOI":"10.1210\/jc.2017-00823","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T07:35:11Z","timestamp":1498894511000},"page":"3461-3469","source":"Crossref","is-referenced-by-count":91,"title":["Resetting the Abnormal Circadian Cortisol Rhythm in Adrenal Incidentaloma Patients With Mild Autonomous Cortisol Secretion"],"prefix":"10.1210","volume":"102","author":[{"given":"Miguel","family":"Debono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Chadarevian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Gueroult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Abitbol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Newell-Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"issue":"5","key":"key\n\t\t\t\t20170906135612_B1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S2213-8587(13)70211-0","article-title":"Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing\u2019s syndrome: a 15-year retrospective study","volume":"2","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"12","key":"key\n\t\t\t\t20170906135612_B2","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1210\/jc.2014-3007","article-title":"Cortisol as a marker for increased mortality in patients with incidental adrenocortical adenomas","volume":"99","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"key\n\t\t\t\t20170906135612_B3","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJMcp065470","article-title":"Clinical practice. The incidentally discovered adrenal mass","volume":"356","year":"2007","journal-title":"N Engl J Med"},{"issue":"5","key":"key\n\t\t\t\t20170906135612_B4","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/jc.2010-2722","article-title":"Clinical review: diagnosis and treatment of subclinical hypercortisolism","volume":"96","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"key\n\t\t\t\t20170906135612_B5","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-16-0467","article-title":"Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors","volume":"175","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"9522","key":"key\n\t\t\t\t20170906135612_B6","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing\u2019s syndrome","volume":"367","year":"2006","journal-title":"Lancet"},{"issue":"9996","key":"key\n\t\t\t\t20170906135612_B7","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing\u2019s syndrome","volume":"386","year":"2015","journal-title":"Lancet"},{"issue":"4","key":"key\n\t\t\t\t20170906135612_B8","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/EJE-11-1039","article-title":"Progressively increased patterns of subclinical cortisol hypersecretion in adrenal incidentalomas differently predict major metabolic and cardiovascular outcomes: a large cross-sectional study","volume":"166","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"key\n\t\t\t\t20170906135612_B9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.7326\/0003-4819-147-8-200710160-00006","article-title":"Subclinical hypercortisolism among outpatients referred for osteoporosis","volume":"147","year":"2007","journal-title":"Ann Intern Med"},{"issue":"3","key":"key\n\t\t\t\t20170906135612_B10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/jc.2013-3527","article-title":"Long-term follow-up in adrenal incidentalomas: an Italian multicenter study","volume":"99","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"key\n\t\t\t\t20170906135612_B11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7326\/M16-0547","article-title":"\u201cNonfunctional\u201d adrenal tumors and the risk for incident diabetes and cardiovascular outcomes: a cohort study","volume":"165","year":"2016","journal-title":"Ann Intern Med"},{"issue":"5","key":"key\n\t\t\t\t20170906135612_B12","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing\u2019s syndrome: an Endocrine Society Clinical Practice Guideline","volume":"93","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"key\n\t\t\t\t20170906135612_B13","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1210\/jc.2012-3582","article-title":"Multisystem morbidity and mortality in Cushing\u2019s syndrome: a cohort study","volume":"98","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"key\n\t\t\t\t20170906135612_B14","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1210\/jc.2009-0766","article-title":"Persistent body fat mass and inflammatory marker increases after long-term cure of Cushing\u2019s syndrome","volume":"94","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170906135612_B15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000330416","article-title":"Adipokines and cardiovascular risk in Cushing\u2019s syndrome","volume":"95","year":"2012","journal-title":"Neuroendocrinology"},{"issue":"4","key":"key\n\t\t\t\t20170906135612_B16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.2337\/dc06-1793","article-title":"Serum interleukin-6 correlates with endothelial dysfunction in healthy men independently of insulin sensitivity","volume":"30","year":"2007","journal-title":"Diabetes Care"},{"issue":"8","key":"key\n\t\t\t\t20170906135612_B17","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1210\/jc.2013-4064","article-title":"Patients with apparently nonfunctioning adrenal incidentalomas may be at increased cardiovascular risk due to excessive cortisol secretion","volume":"99","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"key\n\t\t\t\t20170906135612_B18","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1210\/jc.2015-3694","article-title":"Salivary cortisone reflects cortisol exposure under physiological conditions and after hydrocortisone","volume":"101","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"1-2","key":"key\n\t\t\t\t20170906135612_B19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jim.2011.06.033","article-title":"Multiplex measurement of proinflammatory cytokines in human serum: comparison of the Meso Scale Discovery electrochemiluminescence assay and the Cytometric Bead Array","volume":"372","year":"2011","journal-title":"J Immunol Methods"},{"issue":"8","key":"key\n\t\t\t\t20170906135612_B20","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1182\/blood-2004-12-4602","article-title":"Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease","volume":"106","year":"2005","journal-title":"Blood"},{"issue":"11","key":"key\n\t\t\t\t20170906135612_B21","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1210\/jc.2010-1215","article-title":"Salivary cortisone is a potential biomarker for serum free cortisol","volume":"95","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20170906135612_B22","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1210\/jc.2015-3924","article-title":"Effects of the internal circadian system and circadian misalignment on glucose tolerance in chronic shift workers","volume":"101","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"key\n\t\t\t\t20170906135612_B23","doi-asserted-by":"crossref","first-page":"E1402","DOI":"10.1073\/pnas.1516953113","article-title":"Circadian misalignment increases cardiovascular disease risk factors in humans","volume":"113","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"key\n\t\t\t\t20170906135612_B24","first-page":"3082","article-title":"Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning","volume":"84","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"key\n\t\t\t\t20170906135612_B25","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1210\/jc.2015-2853","article-title":"Diurnal cortisol patterns, future diabetes, and impaired glucose metabolism in the Whitehall II cohort study","volume":"101","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"key\n\t\t\t\t20170906135612_B26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2337\/dc12-0702","article-title":"Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"36","year":"2013","journal-title":"Diabetes Care"},{"issue":"10","key":"key\n\t\t\t\t20170906135612_B27","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1161\/ATVBAHA.110.208785","article-title":"C-reactive protein, interleukin 6, fibrinogen and risk of sudden death in European middle-aged men: the PRIME study","volume":"30","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"key\n\t\t\t\t20170906135612_B28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2265.1991.tb03517.x","article-title":"Short and long-term responses to metyrapone in the medical management of 91 patients with Cushing\u2019s syndrome","volume":"35","year":"1991","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"key\n\t\t\t\t20170906135612_B29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4158\/EP09023OR","article-title":"Late-night salivary cortisol for the diagnosis of Cushing syndrome: a meta-analysis","volume":"15","year":"2009","journal-title":"Endocr Pract"},{"issue":"1","key":"key\n\t\t\t\t20170906135612_B30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1530\/EJE-08-0485","article-title":"The limited role of midnight salivary cortisol levels in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentaloma","volume":"160","year":"2009","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"key\n\t\t\t\t20170906135612_B31","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1210\/jc.2008-1542","article-title":"Late-night salivary cortisol for diagnosis of overt and subclinical Cushing\u2019s syndrome in hospitalized and ambulatory patients","volume":"94","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170906135612_B32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.psyneuen.2014.02.020","article-title":"Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men","volume":"44","year":"2014","journal-title":"Psychoneuroendocrinology"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/102\/9\/3461\/19703504\/jc.2017-00823.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T21:01:33Z","timestamp":1504731693000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/jcem\/article\/102\/9\/3461\/3903087\/Resetting-the-Abnormal-Circadian-Cortisol-Rhythm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,30]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,6,30]]},"published-print":{"date-parts":[[2017,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-00823","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,30]]}}}