{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:33:52Z","timestamp":1790987632095,"version":"4.1.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"DOI":"10.1210\/jc.2017-00930","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T10:10:11Z","timestamp":1498903811000},"page":"3683-3691","source":"Crossref","is-referenced-by-count":58,"title":["Plasma Leucine-Rich \u03b1-2-Glycoprotein 1 Predicts Rapid eGFR Decline and Albuminuria Progression in Type 2 Diabetes Mellitus"],"prefix":"10.1210","volume":"102","author":[{"given":"Jian-Jun","family":"Liu","sequence":"first","affiliation":[{"name":"Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Li Ting","family":"Pek","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Ang","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Tavintharan","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Chi","family":"Lim","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for SMART2D study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"key\n\t\t\t\t20180328153134_B1","doi-asserted-by":"crossref","first-page":"15018","DOI":"10.1038\/nrdp.2015.18","article-title":"Diabetic kidney disease","volume":"1","author":"Thomas","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"key\n\t\t\t\t20180328153134_B2","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.2337\/dc14-1296","article-title":"Diabetic kidney disease: a report from an ADA Consensus Conference","volume":"37","author":"Tuttle","year":"2014","journal-title":"Diabetes Care"},{"issue":"9","key":"key\n\t\t\t\t20180328153134_B3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrendo.2013.102","article-title":"Diabetes and its comorbidities\u2014where East meets West","volume":"9","author":"Kong","year":"2013","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"key\n\t\t\t\t20180328153134_B4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1523-1755.2003.00712.x","article-title":"Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64)","volume":"63","author":"Adler","year":"2003","journal-title":"Kidney Int"},{"issue":"1","key":"key\n\t\t\t\t20180328153134_B5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1515\/bchm2.1977.358.1.639","article-title":"[Isolation and characterization of an unknown, leucine-rich 3.1-S-alpha2-glycoprotein from human serum (author\u2019s transl)]","volume":"358","author":"Haupt","year":"1977","journal-title":"Hoppe Seylers Z Physiol Chem"},{"issue":"7","key":"key\n\t\t\t\t20180328153134_B6","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1073\/pnas.82.7.1906","article-title":"Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum","volume":"82","author":"Takahashi","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"key\n\t\t\t\t20180328153134_B7","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/bjc.2011.376","article-title":"A combination of serum leucine-rich \u03b1-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures","volume":"105","author":"Sandanayake","year":"2011","journal-title":"Br J Cancer"},{"issue":"39","key":"key\n\t\t\t\t20180328153134_B8","doi-asserted-by":"crossref","first-page":"42118","DOI":"10.18632\/oncotarget.5967","article-title":"LRG1 expression indicates unfavorable clinical outcome in hepatocellular carcinoma","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"issue":"9","key":"key\n\t\t\t\t20180328153134_B9","doi-asserted-by":"crossref","first-page":"e74453","DOI":"10.1371\/journal.pone.0074453","article-title":"Leucine-rich \u03b12-glycoprotein is a novel biomarker of neurodegenerative disease in human cerebrospinal fluid and causes neurodegeneration in mouse cerebral cortex","volume":"8","author":"Miyajima","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"key\n\t\t\t\t20180328153134_B10","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/CIRCHEARTFAILURE.110.952200","article-title":"Proteomic analysis of coronary sinus serum reveals leucine-rich \u03b12-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure","volume":"4","author":"Watson","year":"2011","journal-title":"Circ Heart Fail"},{"issue":"4","key":"key\n\t\t\t\t20180328153134_B11","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.bbrc.2009.03.104","article-title":"Up-regulation of the expression of leucine-rich alpha(2)-glycoprotein in hepatocytes by the mediators of acute-phase response","volume":"382","author":"Shirai","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"key\n\t\t\t\t20180328153134_B12","doi-asserted-by":"crossref","first-page":"e0162672","DOI":"10.1371\/journal.pone.0162672","article-title":"Sputum leucine-rich alpha-2 glycoprotein as a marker of airway inflammation in asthma","volume":"11","author":"Honda","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"key\n\t\t\t\t20180328153134_B13","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/ard.2009.118919","article-title":"iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases","volume":"69","author":"Serada","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"key\n\t\t\t\t20180328153134_B14","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1002\/ibd.22936","article-title":"Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis","volume":"18","author":"Serada","year":"2012","journal-title":"Inflamm Bowel Dis"},{"issue":"7458","key":"key\n\t\t\t\t20180328153134_B15","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature12345","article-title":"LRG1 promotes angiogenesis by modulating endothelial TGF-\u03b2 signalling","volume":"499","author":"Wang","year":"2013","journal-title":"Nature"},{"issue":"11","key":"key\n\t\t\t\t20180328153134_B16","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1093\/ndt\/gfv254","article-title":"New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis","volume":"30","author":"Glorieux","year":"2015","journal-title":"Nephrol Dial Transplant"},{"issue":"12","key":"key\n\t\t\t\t20180328153134_B17","doi-asserted-by":"crossref","first-page":"e80830","DOI":"10.1371\/journal.pone.0080830","article-title":"Urinary prognostic biomarkers and classification of IgA nephropathy by high resolution mass spectrometry coupled with liquid chromatography","volume":"8","author":"Kalantari","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"key\n\t\t\t\t20180328153134_B18","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1210\/jc.2014-3855","article-title":"Elevation of a novel angiogenic factor, leucine-rich-\u03b12-glycoprotein (LRG1), is associated with arterial stiffness, endothelial dysfunction, and peripheral arterial disease in patients with type 2 diabetes","volume":"100","author":"Pek","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"key\n\t\t\t\t20180328153134_B19","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1172\/JCI72271","article-title":"Molecular mechanisms of diabetic kidney disease","volume":"124","author":"Reidy","year":"2014","journal-title":"J Clin Invest"},{"issue":"1","key":"key\n\t\t\t\t20180328153134_B20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ki.2013.552","article-title":"Phenotypic characteristics of diabetic kidney involvement","volume":"86","author":"Blantz","year":"2014","journal-title":"Kidney Int"},{"issue":"7","key":"key\n\t\t\t\t20180328153134_B21","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2337\/db09-0119","article-title":"Abnormal angiogenesis in diabetic nephropathy","volume":"58","author":"Nakagawa","year":"2009","journal-title":"Diabetes"},{"issue":"1","key":"key\n\t\t\t\t20180328153134_B22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1681\/ASN.2012121218","article-title":"Targeted glomerular angiopoietin-1 therapy for early diabetic kidney disease","volume":"25","author":"Dessapt-Baradez","year":"2013","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"key\n\t\t\t\t20180328153134_B23","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.2337\/db08-1790","article-title":"Vasohibin-1, a negative feedback regulator of angiogenesis, ameliorates renal alterations in a mouse model of diabetic nephropathy","volume":"58","author":"Nasu","year":"2009","journal-title":"Diabetes"},{"issue":"2","key":"key\n\t\t\t\t20180328153134_B24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.semnephrol.2007.01.007","article-title":"Angiogenesis in diabetic nephropathy","volume":"27","author":"Zent","year":"2007","journal-title":"Semin Nephrol"},{"issue":"3","key":"key\n\t\t\t\t20180328153134_B25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1681\/ASN.2007091048","article-title":"The role of inflammatory cytokines in diabetic nephropathy","volume":"19","author":"Navarro-Gonz\u00e1lez","year":"2008","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"key\n\t\t\t\t20180328153134_B26","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.2337\/db08-0061","article-title":"From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy","volume":"57","author":"Qian","year":"2008","journal-title":"Diabetes"},{"issue":"10","key":"key\n\t\t\t\t20180328153134_B27","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/dme.12461","article-title":"High normal albuminuria is independently associated with aortic stiffness in patients with type 2 diabetes","volume":"31","author":"Liu","year":"2014","journal-title":"Diabet Med"},{"issue":"9","key":"key\n\t\t\t\t20180328153134_B28","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20180328153134_B29","first-page":"1","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease.","volume":"3","author":"Kidney Disease","year":"2013","journal-title":"Kidney Int Suppl"},{"issue":"2","key":"key\n\t\t\t\t20180328153134_B30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000084286","article-title":"Diabetic nephropathy: the proteinuria hypothesis","volume":"25","author":"Williams","year":"2005","journal-title":"Am J Nephrol"},{"issue":"24","key":"key\n\t\t\t\t20180328153134_B31","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1001\/jama.2014.6634","article-title":"Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality","volume":"311","author":"Coresh","year":"2014","journal-title":"JAMA"},{"issue":"21","key":"key\n\t\t\t\t20180328153134_B32","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1001\/archinte.168.21.2304","article-title":"Assessing new biomarkers and predictive models for use in clinical practice: a clinician\u2019s guide","volume":"168","author":"McGeechan","year":"2008","journal-title":"Arch Intern Med"},{"issue":"2","key":"key\n\t\t\t\t20180328153134_B33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.7326\/M13-1522","article-title":"Net reclassification improvement: computation, interpretation, and controversies: a literature review and clinician\u2019s guide","volume":"160","author":"Leening","year":"2014","journal-title":"Ann Intern Med"},{"issue":"11","key":"key\n\t\t\t\t20180328153134_B34","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.2337\/dc12-2572","article-title":"Renal structure in normoalbuminuric and albuminuric patients with type 2 diabetes and impaired renal function","volume":"36","author":"Ekinci","year":"2013","journal-title":"Diabetes Care"},{"issue":"11","key":"key\n\t\t\t\t20180328153134_B35","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.2337\/dc13-0298","article-title":"Long-term outcomes of Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy","volume":"36","author":"Shimizu","year":"2013","journal-title":"Diabetes Care"},{"issue":"10","key":"key\n\t\t\t\t20180328153134_B36","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.2337\/db08-0647","article-title":"Inducible overexpression of sFlt-1 in podocytes ameliorates glomerulopathy in diabetic mice","volume":"57","author":"Ku","year":"2008","journal-title":"Diabetes"},{"issue":"6","key":"key\n\t\t\t\t20180328153134_B37","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/01.RES.0000159936.38601.22","article-title":"A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia","volume":"96","author":"Toporsian","year":"2005","journal-title":"Circ Res"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/102\/10\/3683\/20619970\/jc.2017-00930.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T20:03:22Z","timestamp":1522267402000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/102\/10\/3683\/3903089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,30]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,6,30]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-00930","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10,1]]},"published":{"date-parts":[[2017,6,30]]}}}