{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:06:47Z","timestamp":1790521607439,"version":"4.1.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"2","funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["NNF15CC0018486"],"award-info":[{"award-number":["NNF15CC0018486"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["NNF15SA0018346"],"award-info":[{"award-number":["NNF15SA0018346"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"DOI":"10.1210\/jc.2017-01382","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T19:07:11Z","timestamp":1510081631000},"page":"710-721","source":"Crossref","is-referenced-by-count":43,"title":["Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance"],"prefix":"10.1210","volume":"103","author":[{"given":"Paul","family":"Petrus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Bialesova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Checa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shama","family":"Naz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"B\u00e4ckdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gracia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Toft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Dahlman-Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hed\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Dahlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E","family":"Wheelock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Arner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Mejhert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Ryd\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"issue":"1","key":"key\n\t\t\t\t20180205135628_B1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI77812","article-title":"The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux","volume":"126","author":"Samuel","year":"2016","journal-title":"J Clin Invest"},{"issue":"2","key":"key\n\t\t\t\t20180205135628_B2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"key\n\t\t\t\t20180205135628_B3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrendo.2009.102","article-title":"Epigenetic mechanisms that underpin metabolic and cardiovascular diseases","volume":"5","author":"Gluckman","year":"2009","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"key\n\t\t\t\t20180205135628_B4","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/ije\/dyu236","article-title":"Adiposity is associated with DNA methylation profile in adipose tissue","volume":"44","author":"Agha","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"9","key":"key\n\t\t\t\t20180205135628_B5","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.2337\/db13-1459","article-title":"Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes","volume":"63","author":"Nilsson","year":"2014","journal-title":"Diabetes"},{"issue":"9933","key":"key\n\t\t\t\t20180205135628_B6","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/S0140-6736(13)62674-4","article-title":"DNA methylation and body-mass index: a genome-wide analysis","volume":"383","author":"Dick","year":"2014","journal-title":"Lancet"},{"issue":"1","key":"key\n\t\t\t\t20180205135628_B7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13148-015-0126-9","article-title":"The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women","volume":"7","author":"Arner","year":"2015","journal-title":"Clin Epigenetics"},{"issue":"7","key":"key\n\t\t\t\t20180205135628_B8","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nat Rev Genet"},{"issue":"1","key":"key\n\t\t\t\t20180205135628_B9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab"},{"issue":"8","key":"key\n\t\t\t\t20180205135628_B10","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2337\/db11-1508","article-title":"Adipose tissue microRNAs as regulators of CCL2 production in human obesity","volume":"61","author":"Arner","year":"2012","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20180205135628_B11","first-page":"125","volume-title":"Human Cell Culture Protocols","author":"van Harmelen","year":"2012"},{"issue":"7","key":"key\n\t\t\t\t20180205135628_B12","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/stem.2635","article-title":"CD36 is a marker of human adipocyte progenitors with pronounced adipogenic and triglyceride accumulation potential","volume":"35","author":"Gao","year":"2017","journal-title":"Stem Cells"},{"issue":"19","key":"key\n\t\t\t\t20180205135628_B13","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/bioinformatics\/btq431","article-title":"A framework for oligonucleotide microarray preprocessing","volume":"26","author":"Carvalho","year":"2010","journal-title":"Bioinformatics"},{"issue":"1","key":"key\n\t\t\t\t20180205135628_B14","doi-asserted-by":"crossref","first-page":"Article 3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical Bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"issue":"2","key":"key\n\t\t\t\t20180205135628_B15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2337\/db15-0828","article-title":"Numerous genes in loci associated with body fat distribution are linked to adipose function","volume":"65","author":"Dahlman","year":"2016","journal-title":"Diabetes"},{"issue":"1-2","key":"key\n\t\t\t\t20180205135628_B16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jsbmb.2009.12.013","article-title":"11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation","volume":"119","author":"Staab","year":"2010","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"8","key":"key\n\t\t\t\t20180205135628_B17","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jnutbio.2015.02.002","article-title":"The effects of folic acid on global DNA methylation and colonosphere formation in colon cancer cell lines","volume":"26","author":"Farias","year":"2015","journal-title":"J Nutr Biochem"},{"issue":"6","key":"key\n\t\t\t\t20180205135628_B18","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1124\/mol.60.6.1288","article-title":"Impact of extracellular folate levels on global gene expression","volume":"60","author":"Jhaveri","year":"2001","journal-title":"Mol Pharmacol"},{"issue":"1","key":"key\n\t\t\t\t20180205135628_B19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/carcin\/24.1.81","article-title":"The effect of dietary folate on genomic and p53-specific DNA methylation in rat colon","volume":"24","author":"Sohn","year":"2003","journal-title":"Carcinogenesis"},{"issue":"7","key":"key\n\t\t\t\t20180205135628_B20","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.2337\/db13-1640","article-title":"Elevated S-adenosylhomocysteine alters adipocyte functionality with corresponding changes in gene expression and associated epigenetic marks","volume":"63","author":"Ngo","year":"2014","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20180205135628_B21","volume-title":"Regulation of Expression and Activity of DNA (Cytosine-5) Methyltransferases in Mammalian Cells","author":"Kinney","year":"2011","edition":"1st ed."},{"issue":"3","key":"key\n\t\t\t\t20180205135628_B22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1042\/BJ20090142","article-title":"SUMOylation enhances DNA methyltransferase 1 activity","volume":"421","author":"Lee","year":"2009","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20180205135628_B23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2014.08.005","article-title":"Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes","volume":"55","author":"Malodobra-Mazur","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"key\n\t\t\t\t20180205135628_B24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J Interferon Cytokine Res"},{"issue":"6","key":"key\n\t\t\t\t20180205135628_B25","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"Kanda","year":"2006","journal-title":"J Clin Invest"},{"issue":"12","key":"key\n\t\t\t\t20180205135628_B26","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1073\/pnas.1133870100","article-title":"Monocyte chemoattractant protein 1 in obesity and insulin resistance","volume":"100","author":"Sartipy","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"key\n\t\t\t\t20180205135628_B27","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.1210\/jc.2005-0369","article-title":"A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjects","volume":"90","author":"Dahlman","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20180205135628_B28","doi-asserted-by":"crossref","first-page":"e17154","DOI":"10.1371\/journal.pone.0017154","article-title":"Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages","volume":"6","author":"Meijer","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"key\n\t\t\t\t20180205135628_B29","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s10654-004-2253-z","article-title":"Body mass index and serum folate in childbearing age women","volume":"19","author":"Mojtabai","year":"2004","journal-title":"Eur J Epidemiol"},{"issue":"1","key":"key\n\t\t\t\t20180205135628_B30","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.clim.2009.06.008","article-title":"Folate\/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1","volume":"133","author":"Hammons","year":"2009","journal-title":"Clin Immunol"},{"issue":"8","key":"key\n\t\t\t\t20180205135628_B31","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/sj.ijo.0803265","article-title":"Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects","volume":"30","author":"Solini","year":"2006","journal-title":"Int J Obes"},{"issue":"2","key":"key\n\t\t\t\t20180205135628_B32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/oby.2009.246","article-title":"Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice","volume":"18","author":"Kamei","year":"2010","journal-title":"Obesity (Silver Spring)"},{"issue":"3","key":"key\n\t\t\t\t20180205135628_B33","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2337\/db10-1574","article-title":"Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance","volume":"61","author":"M\u00e4rker","year":"2012","journal-title":"Diabetes"},{"issue":"7","key":"key\n\t\t\t\t20180205135628_B34","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ijo.2011.200","article-title":"Hypoxia reduces the response of human adipocytes towards TNF\u03b1 resulting in reduced NF-\u03baB signaling and MCP-1 secretion","volume":"36","author":"Famulla","year":"2012","journal-title":"Int J Obes"},{"issue":"3","key":"key\n\t\t\t\t20180205135628_B35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00394-011-0218-z","article-title":"Differential effects of 1\u03b1,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes","volume":"51","author":"Lorente-Cebri\u00e1n","year":"2012","journal-title":"Eur J Nutr"},{"issue":"3","key":"key\n\t\t\t\t20180205135628_B36","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2249.2010.04260.x","article-title":"Investigation of nuclear factor-\u03baB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes","volume":"162","author":"Turner","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"key\n\t\t\t\t20180205135628_B37","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/oby.2008.607","article-title":"Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes","volume":"17","author":"Kopp","year":"2009","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"key\n\t\t\t\t20180205135628_B38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cmet.2014.12.014","article-title":"Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes","volume":"21","author":"Multhaup","year":"2015","journal-title":"Cell Metab"},{"issue":"1","key":"key\n\t\t\t\t20180205135628_B39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yhbeh.2014.02.007","article-title":"Sexual dimorphism in white and brown adipose tissue with obesity and inflammation","volume":"66","author":"Bloor","year":"2014","journal-title":"Horm Behav"},{"issue":"4","key":"key\n\t\t\t\t20180205135628_B40","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1080\/15592294.2017.1281501","article-title":"Potential epigenetic biomarkers of obesity-related insulin resistance in human whole-blood","volume":"12","author":"Day","year":"2017","journal-title":"Epigenetics"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/103\/2\/710\/23792122\/jc.2017-01382.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T13:33:11Z","timestamp":1589808791000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/103\/2\/710\/4600237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,7]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,11,7]]},"published-print":{"date-parts":[[2018,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-01382","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2]]},"published":{"date-parts":[[2017,11,7]]}}}