{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:20:08Z","timestamp":1791894008746,"version":"4.3.4"},"reference-count":48,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"DOI":"10.1210\/jc.2017-01593","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T17:59:04Z","timestamp":1509559144000},"page":"281-287","source":"Crossref","is-referenced-by-count":57,"title":["Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications"],"prefix":"10.1210","volume":"103","author":[{"given":"Richard H","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sloane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W","family":"Lyles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Van Houtven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"LaFleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathleen","family":"Col\u00f3n-Emeric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,11,1]]},"reference":[{"key":"key\n\t\t\t\t20180105135258_B1","volume-title":"National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014","author":"Centers for Disease Control and Prevention","year":"2014"},{"issue":"4","key":"key\n\t\t\t\t20180105135258_B2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00198-006-0253-4","article-title":"Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes\u2014a meta-analysis","volume":"18","year":"2007","journal-title":"Osteoporos Int"},{"issue":"6","key":"key\n\t\t\t\t20180105135258_B3","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.bone.2007.02.021","article-title":"Biphasic fracture risk in diabetes: a population-based study","volume":"40","year":"2007","journal-title":"Bone"},{"issue":"8","key":"key\n\t\t\t\t20180105135258_B4","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1359\/jbmr.080323","article-title":"Fracture risk in type 2 diabetes: update of a population-based study","volume":"23","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"4","key":"key\n\t\t\t\t20180105135258_B5","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2337\/dc06-1851","article-title":"The risk of hip fractures in older individuals with diabetes: a population-based study","volume":"30","year":"2007","journal-title":"Diabetes Care"},{"issue":"21","key":"key\n\t\t\t\t20180105135258_B6","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1001\/jama.2011.715","article-title":"Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes","volume":"305","author":"Study of Osteoporotic Fractures (SOF) Research GroupOsteoporotic Fractures in Men (MrOS) Research GroupHealth, Aging, and Body Composition (Health ABC) Research Group","year":"2011","journal-title":"JAMA"},{"issue":"12","key":"key\n\t\t\t\t20180105135258_B7","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00198-005-1909-1","article-title":"Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study","volume":"16","author":"de L","year":"2005","journal-title":"Osteoporos Int"},{"issue":"5","key":"key\n\t\t\t\t20180105135258_B8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/aje\/kwm106","article-title":"Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture","volume":"166","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"4","key":"key\n\t\t\t\t20180105135258_B9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nrendo.2016.153","article-title":"Mechanisms of diabetes mellitus-induced bone fragility","volume":"13","author":"IOF Bone and Diabetes Working Group","year":"2017","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"key\n\t\t\t\t20180105135258_B10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S2213-8587(15)00283-1","article-title":"Type 2 diabetes and the skeleton: new insights into sweet bones","volume":"4","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"7","key":"key\n\t\t\t\t20180105135258_B11","doi-asserted-by":"crossref","first-page":"M473","DOI":"10.1093\/gerona\/57.7.M473","article-title":"Falls in African American and white community-dwelling elderly residents","volume":"57","year":"2002","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"10","key":"key\n\t\t\t\t20180105135258_B12","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.2337\/diacare.25.10.1749","article-title":"Older women with diabetes have a higher risk of falls: a prospective study","volume":"25","year":"2002","journal-title":"Diabetes Care"},{"issue":"3","key":"key\n\t\t\t\t20180105135258_B13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2337\/dc07-1152","article-title":"Diabetes-related complications, glycemic control, and falls in older adults","volume":"31","author":"Health, Aging, and Body Composition Study","year":"2008","journal-title":"Diabetes Care"},{"issue":"9","key":"key\n\t\t\t\t20180105135258_B14","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1210\/jc.2006-0614","article-title":"Risk of fracture in women with type 2 diabetes: the Women\u2019s Health Initiative Observational Study","volume":"91","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"key\n\t\t\t\t20180105135258_B15","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1111\/jgs.13556","article-title":"Functional impairments mediate association between clinical fracture risk and type 2 diabetes mellitus in older women","volume":"63","year":"2015","journal-title":"J Am Geriatr Soc"},{"issue":"7","key":"key\n\t\t\t\t20180105135258_B16","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1210\/jc.2008-2498","article-title":"Pentosidine and increased fracture risk in older adults with type 2 diabetes","volume":"94","author":"Health, Aging, and Body Composition Study","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"key\n\t\t\t\t20180105135258_B17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbmr.1763","article-title":"Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures","volume":"28","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"1","key":"key\n\t\t\t\t20180105135258_B18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00223-008-9195-5","article-title":"Diabetes and its complications and their relationship with risk of fractures in type 1 and 2 diabetes","volume":"84","year":"2009","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"key\n\t\t\t\t20180105135258_B19","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jdiacomp.2011.02.004","article-title":"Prevalence of osteoporosis and vertebral fractures in postmenopausal women with type 2 diabetes mellitus and their relationship with duration of the disease and chronic complications","volume":"25","year":"2011","journal-title":"J Diabetes Complications"},{"issue":"1","key":"key\n\t\t\t\t20180105135258_B20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2337\/dc07-1072","article-title":"Increased risks of hip fracture in diabetic patients of Taiwan: a population-based study","volume":"31","year":"2008","journal-title":"Diabetes Care"},{"issue":"2","key":"key\n\t\t\t\t20180105135258_B21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/jbmr.556","article-title":"FRAX underestimates fracture risk in patients with diabetes","volume":"27","year":"2012","journal-title":"J Bone Miner Res"},{"issue":"6","key":"key\n\t\t\t\t20180105135258_B22","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2337\/dc12-1188","article-title":"High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study","volume":"36","year":"2013","journal-title":"Diabetes Care"},{"issue":"14","key":"key\n\t\t\t\t20180105135258_B23","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1001\/archinte.165.14.1612","article-title":"Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study","volume":"165","year":"2005","journal-title":"Arch Intern Med"},{"issue":"10","key":"key\n\t\t\t\t20180105135258_B24","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00125-014-3289-6","article-title":"Fracture risk in diabetic elderly men: the MrOS study","volume":"57","year":"2014","journal-title":"Diabetologia"},{"issue":"5","key":"key\n\t\t\t\t20180105135258_B25","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/01.mlr.0000160417.39497.a9","article-title":"Accuracy of ICD-9-CM codes for identifying cardiovascular and stroke risk factors","volume":"43","year":"2005","journal-title":"Med Care"},{"key":"key\n\t\t\t\t20180105135258_B26","volume-title":"VA\/DoD Clinical Practice Guideline for the Management of Type 2 Diabetes Mellitus in Primary Care, version 5.0","year":"2017"},{"issue":"6","key":"key\n\t\t\t\t20180105135258_B27","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.2337\/dc14-1982","article-title":"Diabetic peripheral neuropathy compromises balance during daily activities","volume":"38","year":"2015","journal-title":"Diabetes Care"},{"issue":"2","key":"key\n\t\t\t\t20180105135258_B28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1464-5491.2009.02914.x","article-title":"Lower-limb risk factors for falls in people with diabetes mellitus","volume":"27","year":"2010","journal-title":"Diabet Med"},{"issue":"3","key":"key\n\t\t\t\t20180105135258_B29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/00000441-200609000-00003","article-title":"Secondary hyperparathyroidism and hypovitaminosis D in African-Americans with decompensated heart failure","volume":"332","year":"2006","journal-title":"Am J Med Sci"},{"issue":"3","key":"key\n\t\t\t\t20180105135258_B30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0002-9343(97)00142-3","article-title":"Bone mass, vitamin D deficiency, and hyperparathyroidism in congestive heart failure","volume":"103","year":"1997","journal-title":"Am J Med"},{"issue":"3","key":"key\n\t\t\t\t20180105135258_B31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/eurjhf\/hfs002","article-title":"Bone mass loss in chronic heart failure is associated with secondary hyperparathyroidism and has prognostic significance","volume":"14","year":"2012","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"key\n\t\t\t\t20180105135258_B32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00000441-200601000-00009","article-title":"Secondary hyperparathyroidism in patients with untreated and treated congestive heart failure","volume":"331","year":"2006","journal-title":"Am J Med Sci"},{"issue":"5","key":"key\n\t\t\t\t20180105135258_B33","doi-asserted-by":"crossref","first-page":"H2023","DOI":"10.1152\/ajpheart.00477.2004","article-title":"Loss of bone minerals and strength in rats with aldosteronism","volume":"287","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"key\n\t\t\t\t20180105135258_B34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000441-200507000-00001","article-title":"Bone loss in rats with aldosteronism","volume":"330","year":"2005","journal-title":"Am J Med Sci"},{"issue":"2","key":"key\n\t\t\t\t20180105135258_B35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jacc.2008.03.039","article-title":"Fracture risk in men with congestive heart failure risk reduction with spironolactone","volume":"52","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"key\n\t\t\t\t20180105135258_B36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10741-016-9533-z","article-title":"The role of inflammation and cell death in the pathogenesis, progression and treatment of heart failure","volume":"21","year":"2016","journal-title":"Heart Fail Rev"},{"issue":"10","key":"key\n\t\t\t\t20180105135258_B37","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1161\/CIRCULATIONAHA.108.802918","article-title":"Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-\u03baB and inflammatory activation","volume":"119","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180105135258_B38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cyto.2016.01.011","article-title":"TNF-\u03b1 is upregulated in T2DM patients with fracture and promotes the apoptosis of osteoblast cells in vitro in the presence of high glucose","volume":"80","year":"2016","journal-title":"Cytokine"},{"issue":"4","key":"key\n\t\t\t\t20180105135258_B39","first-page":"455","article-title":"Chronic inflammation is associated with low physical function in older adults across multiple comorbidities","volume":"64","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"key\n\t\t\t\t20180105135258_B40","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/gerona\/glv007","article-title":"A novel analytic technique to measure associations between circulating biomarkers and physical performance across the adult life span","volume":"71","year":"2016","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"9","key":"key\n\t\t\t\t20180105135258_B41","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1002\/jbmr.2245","article-title":"Inflammatory markers and risk of hip fracture in older white women: the study of osteoporotic fractures","volume":"29","author":"Study of Osteoporotic Fractures (SOF) Research Group","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"1","key":"key\n\t\t\t\t20180105135258_B42","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/1471-2458-12-301","article-title":"Osteoporosis-related fracture case definitions for population-based administrative data","volume":"12","year":"2012","journal-title":"BMC Public Health"},{"issue":"7","key":"key\n\t\t\t\t20180105135258_B43","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0895-4356(92)90047-Q","article-title":"Identification of fractures from computerized Medicare files","volume":"45","year":"1992","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"key\n\t\t\t\t20180105135258_B44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0895-4356(99)00136-5","article-title":"Using medical services claims to assess injuries in the elderly: sensitivity of diagnostic and procedure codes for injury ascertainment","volume":"53","year":"2000","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"key\n\t\t\t\t20180105135258_B45","first-page":"255","article-title":"Bone mineral density scans in veterans","volume":"2","year":"2007","journal-title":"Clin Interv Aging"},{"key":"key\n\t\t\t\t20180105135258_B46","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1093\/geront\/gnv677","article-title":"Fracture rates and bone density among postmenopausal veteran and non-veteran women from the Women\u2019s Health Initiative","volume":"56","year":"2016","journal-title":"Gerontologist"},{"issue":"4","key":"key\n\t\t\t\t20180105135258_B47","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.bone.2011.11.014","article-title":"Factors associated with screening or treatment initiation among male United States veterans at risk for osteoporosis fracture","volume":"50","year":"2012","journal-title":"Bone"},{"issue":"6","key":"key\n\t\t\t\t20180105135258_B48","first-page":"427","article-title":"Prevalence of osteoporosis in men in a VA rehabilitation center","volume":"16","year":"2010","journal-title":"Am J Manag Care"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/103\/1\/281\/23270239\/jc.2017-01593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T18:32:17Z","timestamp":1515177137000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/jcem\/article\/103\/1\/281\/4584213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,1]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,11,1]]},"published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-01593","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1]]},"published":{"date-parts":[[2017,11,1]]}}}