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Adolescent consent in health care decision-making and the adolescent brain. Available at: http:\/\/digitalcommons.law.umaryland.edu\/cgi\/viewcontent.cgi?article=1124&context=jhclp. Accessed 25 June 2017."},{"key":"key\n\t\t\t\t20171106135800_B122","unstructured":"NHS. Prescribing of cross-sex hormones as part of the gender identity development service for children and adolescents. Available at: https:\/\/www.england.nhs.uk\/commissioning\/wp-content\/uploads\/sites\/12\/2016\/08\/clinical-com-pol-16046p.pdf. Accessed 14 June 2017."},{"issue":"4","key":"key\n\t\t\t\t20171106135800_B123","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000356922","article-title":"Physiological estrogen replacement therapy for puberty induction in girls: a clinical observational study","volume":"81","year":"2014","journal-title":"Horm Res Paediatr"},{"issue":"3","key":"key\n\t\t\t\t20171106135800_B124","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1089\/lgbt.2014.0018","article-title":"Subcutaneous testosterone: an effective delivery mechanism for masculinizing young transgender men","volume":"1","year":"2014","journal-title":"LGBT Health"},{"key":"key\n\t\t\t\t20171106135800_B125","doi-asserted-by":"crossref","unstructured":"Spratt DI , StewartI, SavageC, CraigW, SpackNP, ChandlerDW, SprattLV, EimickeT, OlshanJS. Subcutaneous injection of testosterone is an effective and preferred alternative to intramuscular injection: demonstration in female-to-male transgender patients. J Clin Endocrinol Metab. 2017. doi:10.1210\/jc.2017-00359","DOI":"10.1210\/jc.2017-00359"},{"issue":"2","key":"key\n\t\t\t\t20171106135800_B126","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.psyneuen.2012.05.018","article-title":"Pharmacokinetics of testosterone and estradiol gel preparations in healthy young men","volume":"38","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"key\n\t\t\t\t20171106135800_B127","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/j.1365-2265.2009.03573.x","article-title":"Effects of oestradiol on gonadotrophin levels in normal and castrated men","volume":"71","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t20171106135800_B128","unstructured":"Money J, Ehrhardt A. Man & woman, boy & girl: differentiation and dimorphism of gender identity from conception to maturity. Baltimore, MD: Johns Hopkins University Press; 1972:202\u2013206."},{"issue":"1","key":"key\n\t\t\t\t20171106135800_B129","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/jsm.12363","article-title":"Effects of different steps in gender reassignment therapy on psychopathology: a prospective study of persons with a gender identity disorder","volume":"11","year":"2014","journal-title":"J Sex Med"},{"key":"key\n\t\t\t\t20171106135800_B130","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.2147\/NDT.S95310","article-title":"The effect of cross-sex hormonal treatment on gender dysphoria individuals\u2019 mental health: a systematic review","volume":"12","year":"2016","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"4","key":"key\n\t\t\t\t20171106135800_B131","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1743-6109.2007.00646.x","article-title":"Review of studies of androgen treatment of female-to-male transsexuals: effects and risks of administration of androgens to females","volume":"5","year":"2008","journal-title":"J Sex Med"},{"issue":"4","key":"key\n\t\t\t\t20171106135800_B132","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.1365-2265.2003.01821.x","article-title":"Endocrine intervention for transsexuals","volume":"59","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"key\n\t\t\t\t20171106135800_B133","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4158\/EP.9.1.12","article-title":"Endocrinologic treatment of gender identity disorders","volume":"9","year":"2003","journal-title":"Endocr Pract"},{"issue":"5","key":"key\n\t\t\t\t20171106135800_B134","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/cen.12753","article-title":"Endocrine care of transpeople part I. 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Andrologia. 2017;49(6).","DOI":"10.1111\/and.12666"},{"key":"key\n\t\t\t\t20171106135800_B175","doi-asserted-by":"crossref","first-page":"bcr0220091589","DOI":"10.1136\/bcr.02.2009.1589","article-title":"Autonomous prolactin secretion in two male-to-female transgender patients using conventional oestrogen dosages","volume":"2009","year":"2009","journal-title":"BMJ Case Rep"},{"issue":"1","key":"key\n\t\t\t\t20171106135800_B176","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.2009.03632.x","article-title":"Effect of sex steroid use on cardiovascular risk in transsexual individuals: a systematic review and meta-analyses","volume":"72","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"key\n\t\t\t\t20171106135800_B177","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1745-7262.2006.00204.x","article-title":"Testosterone decreases adiponectin levels in female to male transsexuals","volume":"8","year":"2006","journal-title":"Asian J Androl"},{"issue":"5","key":"key\n\t\t\t\t20171106135800_B178","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1046\/j.1365-2265.2003.01753.x","article-title":"Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects","volume":"58","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4 Pt 1","key":"key\n\t\t\t\t20171106135800_B179","first-page":"590","article-title":"Sex steroids, insulin, and arterial stiffness in women and men","volume":"34","year":"1999","journal-title":"Hypertension"},{"issue":"1","key":"key\n\t\t\t\t20171106135800_B180","first-page":"265","article-title":"Induction of insulin resistance by androgens and estrogens","volume":"79","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20171106135800_B181","unstructured":"Maraka S. Effect of sex steroids on lipids, venous thromboembolism, cardiovascular disease and mortality in transgender individuals: a systematic review and meta-analysis. Available at: http:\/\/press.endocrine.org\/doi\/abs\/10.1210\/endo-meetings.2016.RE.15.FRI-136. 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