{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:49:42Z","timestamp":1770414582310,"version":"3.49.0"},"reference-count":34,"publisher":"The Endocrine Society","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK067269"],"award-info":[{"award-number":["R01 DK067269"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK067269-04S1"],"award-info":[{"award-number":["R01 DK067269-04S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MO1 RR00211"],"award-info":[{"award-number":["MO1 RR00211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>There are ethnic differences in glucoregulation and prevalence of type 2 diabetes, but studies on the role of genetics in modifying ethnic effects in normoglycemic African-Americans and Caucasians are limited. Therefore, we investigated glucoregulation in normoglycemic African-Americans and Caucasians with or without parental diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Fifty subjects with parental diabetes (from the Pathobiology of Prediabetes in a Biracial Cohort Study) and 50 subjects without parental diabetes were matched in age, sex, ethnicity, and body mass index (BMI). Subjects underwent a 75-g oral glucose tolerance test (OGTT), physical examination, anthropometry, biochemistries, indirect calorimetry and assessment of body composition, insulin sensitivity by euglycemic clamp (Si-clamp), and \u03b2-cell function by Disposition index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age was 40.5 \u00b1 11.6 years, BMI 28.7 \u00b1 5.9 kg\/m2, fasting plasma glucose 90.2 \u00b1 5.9 mg\/dL, and 2-hour postglucose 120.0 \u00b1 26.8 mg\/dL. Offspring with parental diabetes showed higher glycemic excursion during OGTT\u2013area under the curve\u2013glucose (16,005.6 \u00b1 2324.7 vs 14,973.8 \u00b1 1819.9, P &amp;lt; 0.005), lower Si-clamp (0.132 \u00b1 0.068 vs 0.162 \u00b1 0.081 \u00b5mol\/kg fat-free mass\/min\/pmol\/L, P &amp;lt; 0.05), and lower Disposition index (8.74 \u00b1 5.72 vs 11.83 \u00b1 7.49, P &amp;lt; 0.05). Compared with lean subjects without parental diabetes, \u03b2 cell function was lower by \u223c30% in lean subjects with parental diabetes, \u223c40% in obese subjects without parental diabetes, and \u223c50% in obese individuals with parental diabetes (P &amp;lt; 0.0001). African-Americans without parental diabetes had \u223c40% lower insulin sensitivity (P &amp;lt; 0.001), twofold higher acute insulin secretion (P &amp;lt; 0.001), but \u223c30% lower Disposition index (P &amp;lt; 0.01) compared with Caucasians without parental diabetes. Remarkably, there were no significant differences by ethnicity in these glucoregulatory measures among subjects with parental diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Offspring with parental diabetes harbor substantial impairments in glucoregulation compared with individuals without parental diabetes. Ethnic disparities in glucoregulation were abrogated by parental diabetes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2017-01895","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T19:08:18Z","timestamp":1512414498000},"page":"514-522","source":"Crossref","is-referenced-by-count":6,"title":["Parental History of Type 2 Diabetes Abrogates Ethnic Disparities in Key Glucoregulatory Indices"],"prefix":"10.1210","volume":"103","author":[{"given":"Ebenezer","family":"Nyenwe","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibiye","family":"Owei","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Dagogo-Jack","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"2020071622253449800_B1","unstructured":"Centers for Disease Control and Prevention. 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