{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:44:23Z","timestamp":1769229863109,"version":"3.49.0"},"reference-count":33,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"DOI":"10.1210\/jc.2017-02265","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T19:41:35Z","timestamp":1512157295000},"page":"1088-1094","source":"Crossref","is-referenced-by-count":22,"title":["Pramlintide but Not Liraglutide Suppresses Meal-Stimulated Glucagon Responses in Type 1 Diabetes"],"prefix":"10.1210","volume":"103","author":[{"given":"Alfonso","family":"Galderisi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"},{"name":"Department of Women\u2019s and Children\u2019s Health, University of Padova, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Sherr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"VanName","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Carria","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Zgorski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Tichy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Weyman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eda","family":"Cengiz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Weinzimer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Tamborlane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrinology and Diabetes Section, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"issue":"7","key":"key\n\t\t\t\t20180306135510_B1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2337\/dc08-0575","article-title":"Too much glucagon, too little insulin: time course of pancreatic islet dysfunction in new-onset type 1 diabetes","volume":"31","author":"Brown","year":"2008","journal-title":"Diabetes Care"},{"issue":"3","key":"key\n\t\t\t\t20180306135510_B2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF00400639","article-title":"Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM","volume":"38","author":"Dinneen","year":"1995","journal-title":"Diabetologia"},{"issue":"6","key":"key\n\t\t\t\t20180306135510_B3","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.2337\/dc13-2612","article-title":"Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis","volume":"37","author":"Sherr","year":"2014","journal-title":"Diabetes Care"},{"issue":"8","key":"key\n\t\t\t\t20180306135510_B4","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1210\/jc.2007-0244","article-title":"Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes","volume":"92","author":"P\u00f6rksen","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"key\n\t\t\t\t20180306135510_B5","doi-asserted-by":"crossref","first-page":"934","DOI":"10.2337\/dc07-1967","article-title":"Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas","volume":"31","author":"Weinzimer","year":"2008","journal-title":"Diabetes Care"},{"issue":"4","key":"key\n\t\t\t\t20180306135510_B6","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s00125-014-3486-3","article-title":"The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes","volume":"58","author":"Fredheim","year":"2015","journal-title":"Diabetologia"},{"issue":"3","key":"key\n\t\t\t\t20180306135510_B7","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2337\/diacare.26.3.881","article-title":"Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)","volume":"26","author":"Monnier","year":"2003","journal-title":"Diabetes Care"},{"issue":"14","key":"key\n\t\t\t\t20180306135510_B8","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1001\/jama.295.14.1681","article-title":"Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes","volume":"295","author":"Monnier","year":"2006","journal-title":"JAMA"},{"issue":"2","key":"key\n\t\t\t\t20180306135510_B9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4158\/EP15869.RA","article-title":"The emerging role of adjunctive noninsulin antihyperglycemic therapy in the management of type 1 diabetes","volume":"22","author":"Bode","year":"2016","journal-title":"Endocr Pract"},{"issue":"9","key":"key\n\t\t\t\t20180306135510_B10","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1080\/17425247.2017.1360862","article-title":"Moving beyond subcutaneous insulin: the application of adjunctive therapies to the treatment of type 1 diabetes","volume":"14","author":"Ang","year":"2017","journal-title":"Expert Opin Drug Deliv"},{"issue":"5","key":"key\n\t\t\t\t20180306135510_B11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S2213-8587(16)00052-8","article-title":"Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis","volume":"4","author":"Wu","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"key\n\t\t\t\t20180306135510_B12","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1210\/jc.2015-3952","article-title":"Effect of pramlintide on postprandial glucose fluxes in type 1 diabetes","volume":"101","author":"Hinshaw","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"key\n\t\t\t\t20180306135510_B13","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.2337\/dc14-1984","article-title":"Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: a randomized, open-label trial","volume":"38","author":"Meier","year":"2015","journal-title":"Diabetes Care"},{"issue":"7","key":"key\n\t\t\t\t20180306135510_B14","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2337\/dc16-0089","article-title":"Mitigating meal-related glycemic excursions in an insulin-sparing manner during closed-loop insulin delivery: the beneficial effects of adjunctive pramlintide and liraglutide","volume":"39","author":"Sherr","year":"2016","journal-title":"Diabetes Care"},{"issue":"9","key":"key\n\t\t\t\t20180306135510_B15","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S2213-8587(16)00039-5","article-title":"Non-insulin drugs to treat hyperglycaemia in type 1 diabetes mellitus","volume":"4","author":"Frandsen","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10","key":"key\n\t\t\t\t20180306135510_B16","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2337\/dc16-0690","article-title":"Efficacy and safety of liraglutide added to capped insulin treatment in subjects with type 1 diabetes: The ADJUNCT TWO Randomized Trial","volume":"39","author":"Ahr\u00e9n","year":"2016","journal-title":"Diabetes Care"},{"issue":"3","key":"key\n\t\t\t\t20180306135510_B17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S2213-8587(15)00436-2","article-title":"Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial","volume":"4","author":"Dejgaard","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"key\n\t\t\t\t20180306135510_B18","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1177\/1932296816647976","article-title":"Adjuvant liraglutide and insulin versus insulin monotherapy in the closed-loop system in type 1 diabetes: a randomized open-labeled crossover design trial","volume":"10","author":"Ilkowitz","year":"2016","journal-title":"J Diabetes Sci Technol"},{"issue":"6","key":"key\n\t\t\t\t20180306135510_B19","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.2337\/dc15-1136","article-title":"Addition of liraglutide to insulin in patients with type 1 diabetes: a randomized placebo-controlled clinical trial of 12 weeks","volume":"39","author":"Kuhadiya","year":"2016","journal-title":"Diabetes Care"},{"issue":"10","key":"key\n\t\t\t\t20180306135510_B20","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.2337\/dc16-0691","article-title":"Efficacy and safety of liraglutide added to insulin treatment in type 1 diabetes: The ADJUNCT ONE Treat-To-Target Randomized Trial","volume":"39","author":"Mathieu","year":"2016","journal-title":"Diabetes Care"},{"issue":"3","key":"key\n\t\t\t\t20180306135510_B21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jpeds.2009.03.012","article-title":"Pramlintide lowered glucose excursions and was well-tolerated in adolescents with type 1 diabetes: results from a randomized, single-blind, placebo-controlled, crossover study","volume":"155","author":"Chase","year":"2009","journal-title":"J Pediatr"},{"issue":"10","key":"key\n\t\t\t\t20180306135510_B22","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.2337\/dc06-0042","article-title":"A double-blind, placebo-controlled trial assessing pramlintide treatment in the setting of intensive insulin therapy in type 1 diabetes","volume":"29","author":"Edelman","year":"2006","journal-title":"Diabetes Care"},{"issue":"1","key":"key\n\t\t\t\t20180306135510_B23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diacare.26.1.1","article-title":"Impact of pramlintide on glucose fluctuations and postprandial glucose, glucagon, and triglyceride excursions among patients with type 1 diabetes intensively treated with insulin pumps","volume":"26","author":"Levetan","year":"2003","journal-title":"Diabetes Care"},{"issue":"10","key":"key\n\t\t\t\t20180306135510_B24","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.2337\/dc12-0330","article-title":"Effect of pramlintide on prandial glycemic excursions during closed-loop control in adolescents and young adults with type 1 diabetes","volume":"35","author":"Weinzimer","year":"2012","journal-title":"Diabetes Care"},{"issue":"4","key":"key\n\t\t\t\t20180306135510_B25","doi-asserted-by":"crossref","first-page":"724","DOI":"10.2337\/diacare.25.4.724","article-title":"A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes","volume":"25","author":"Whitehouse","year":"2002","journal-title":"Diabetes Care"},{"issue":"3","key":"key\n\t\t\t\t20180306135510_B26","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/dom.12593","article-title":"Gastrointestinal actions of glucagon-like peptide-1-based therapies: glycaemic control beyond the pancreas","volume":"18","author":"Smits","year":"2016","journal-title":"Diabetes Obes Metab"},{"issue":"4","key":"key\n\t\t\t\t20180306135510_B27","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.2337\/db16-0755","article-title":"Glucagon-like peptide 1 and its analogs act in the dorsal raphe and modulate central serotonin to reduce appetite and body weight","volume":"66","author":"Anderberg","year":"2017","journal-title":"Diabetes"},{"issue":"12","key":"key\n\t\t\t\t20180306135510_B28","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.2337\/dc14-0893","article-title":"Liraglutide and the preservation of pancreatic \u03b2-cell function in early type 2 diabetes: the LIBRA trial","volume":"37","author":"Retnakaran","year":"2014","journal-title":"Diabetes Care"},{"issue":"4","key":"key\n\t\t\t\t20180306135510_B29","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/jdi.12457","article-title":"Combination therapy with liraglutide and insulin in Japanese patients with type 2 diabetes: A 36-week, randomized, double-blind, parallel-group trial","volume":"7","author":"Seino","year":"2016","journal-title":"J Diabetes Investig"},{"issue":"11","key":"key\n\t\t\t\t20180306135510_B30","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/j.1464-5491.2004.01319.x","article-title":"Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in type 1 diabetes mellitus: a 1-year, randomized controlled trial","volume":"21","author":"Ratner","year":"2004","journal-title":"Diabet Med"},{"issue":"7","key":"key\n\t\t\t\t20180306135510_B31","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0026-0495(99)90232-9","article-title":"The amylin analog pramlintide improves glycemic control and reduces postprandial glucagon concentrations in patients with type 1 diabetes mellitus","volume":"48","author":"Nyholm","year":"1999","journal-title":"Metabolism"},{"issue":"6","key":"key\n\t\t\t\t20180306135510_B32","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1463-1326.2012.01557.x","article-title":"Liraglutide: short-lived effect on gastric emptying -- long lasting effects on body weight","volume":"14","author":"Jelsing","year":"2012","journal-title":"Diabetes Obes Metab"},{"issue":"6","key":"key\n\t\t\t\t20180306135510_B33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.4158\/EP13065.OR","article-title":"Liraglutide as additional treatment to insulin in obese patients with type 1 diabetes mellitus","volume":"19","author":"Kuhadiya","year":"2013","journal-title":"Endocr Pract"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/103\/3\/1088\/24262780\/jc.2017-02265.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T18:55:36Z","timestamp":1520362536000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/103\/3\/1088\/4677376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,1]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,12,1]]},"published-print":{"date-parts":[[2018,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-02265","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3]]},"published":{"date-parts":[[2017,12,1]]}}}