{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:21:34Z","timestamp":1781594494854,"version":"3.54.5"},"reference-count":40,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"DOI":"10.1210\/jc.2017-02406","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T05:31:51Z","timestamp":1514093511000},"page":"1206-1213","source":"Crossref","is-referenced-by-count":50,"title":["Changes of Circulating MicroRNAs in Response to Treatment With Teriparatide or Denosumab in Postmenopausal Osteoporosis"],"prefix":"10.1210","volume":"103","author":[{"given":"Athanasios D","family":"Anastasilakis","sequence":"first","affiliation":[{"name":"Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polyzois","family":"Makras","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, 251 Hellenic Air Force and VA General Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pikilidou","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Molecular Endocrinology, First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Symeon","family":"Tournis","sequence":"additional","affiliation":[{"name":"Laboratory of Research of Musculoskeletal System \u201cTh. Garofalidis,\u201d Medical School, University of Athens, KAT Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Makris","sequence":"additional","affiliation":[{"name":"Laboratory of Research of Musculoskeletal System \u201cTh. Garofalidis,\u201d Medical School, University of Athens, KAT Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Bisbinas","sequence":"additional","affiliation":[{"name":"First Department of Orthopedics, 424 General Military Hospital, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Tsave","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Molecular Endocrinology, First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G","family":"Yovos","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Molecular Endocrinology, First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P","family":"Yavropoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Molecular Endocrinology, First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"issue":"1","key":"2019041121311060500_B1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA translation and stability by microRNAs","volume":"79","author":"Fabian","year":"2010","journal-title":"Annu Rev Biochem"},{"key":"2019041121311060500_B2","first-page":"1231","article-title":"MicroRNAs: synthesis, mechanism, function, and recent clinical trials","volume-title":"Biochim Biophys Acta","author":"Wahid","year":"2010"},{"key":"2019041121311060500_B3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biochi.2014.05.004","article-title":"MicroRNA and diseases: therapeutic potential as new generation of drugs","volume":"104","author":"Wahid","year":"2014","journal-title":"Biochimie"},{"issue":"46","key":"2019041121311060500_B4","doi-asserted-by":"crossref","first-page":"33347","DOI":"10.1074\/jbc.M113.484568","article-title":"miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration","volume":"288","author":"Franceschetti","year":"2013","journal-title":"J Biol Chem"},{"issue":"2","key":"2019041121311060500_B5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bone.2013.07.007","article-title":"MicroRNA-124 regulates osteoclast differentiation","volume":"56","author":"Lee","year":"2013","journal-title":"Bone"},{"issue":"5","key":"2019041121311060500_B6","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/jcb.25026","article-title":"miR-124 negatively regulates osteogenic differentiation and in vivo bone formation of mesenchymal stem cells","volume":"116","author":"Qadir","year":"2015","journal-title":"J Cell Biochem"},{"issue":"8","key":"2019041121311060500_B7","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1002\/jbmr.2175","article-title":"Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures","volume":"29","author":"Seeliger","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"37","key":"2019041121311060500_B8","doi-asserted-by":"crossref","first-page":"13906","DOI":"10.1073\/pnas.0804438105","article-title":"A microRNA signature for a BMP2-induced osteoblast lineage commitment program","volume":"105","author":"Li","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"2019041121311060500_B9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1615\/CritRevOncog.2013006128","article-title":"Emerging roles of microRNAs in the Wnt signaling network","volume":"18","author":"Schepeler","year":"2013","journal-title":"Crit Rev Oncog"},{"key":"2019041121311060500_B10","first-page":"1652417","article-title":"The regulatory roles of microRNAs in bone remodeling and perspectives as biomarkers in osteoporosis","volume-title":"Biomed Res Int","author":"Sun","year":"2016"},{"key":"2019041121311060500_B11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mce.2015.10.015","article-title":"Circulating microRNAs as novel biomarkers for bone diseases\u2014complex signatures for multifactorial diseases","volume":"432","author":"Hackl","year":"2016","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"2019041121311060500_B12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1530\/EJE-16-0583","article-title":"Expression of microRNAs that regulate bone turnover in the serum of postmenopausal women with low bone mass and vertebral fractures","volume":"176","author":"Yavropoulou","year":"2017","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"2019041121311060500_B13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00223-015-0036-z","article-title":"Serum circulating microRNAs as biomarkers of osteoporotic fracture","volume":"97","author":"Panach","year":"2015","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"2019041121311060500_B14","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00198-016-3847-5","article-title":"MicroRNAs in bone diseases","volume":"28","author":"Gennari","year":"2017","journal-title":"Osteoporos Int"},{"issue":"7","key":"2019041121311060500_B15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","article-title":"10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension","volume":"5","author":"Bone","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"19","key":"2019041121311060500_B16","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N Engl J Med"},{"issue":"8","key":"2019041121311060500_B17","doi-asserted-by":"crossref","first-page":"e43367","DOI":"10.1371\/journal.pone.0043367","article-title":"The epidemiology of low- and high-energy distal radius fracture in middle-aged and elderly men and women in Southern Norway","volume":"7","author":"Diamantopoulos","year":"2012","journal-title":"PLoS One"},{"issue":"Database issue","key":"2019041121311060500_B18","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"miRBase: annotating high confidence microRNAs using deep sequencing data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"Web Server issue","key":"2019041121311060500_B19","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkt393","article-title":"DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows","volume":"41","author":"Paraskevopoulou","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"2019041121311060500_B20","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/bioinformatics\/bts043","article-title":"Functional microRNA targets in protein coding sequences","volume":"28","author":"Reczko","year":"2012","journal-title":"Bioinformatics"},{"issue":"Database issue","key":"2019041121311060500_B21","doi-asserted-by":"crossref","first-page":"D146","DOI":"10.1093\/nar\/gku1104","article-title":"miRDB: an online resource for microRNA target prediction and functional annotations","volume":"43","author":"Wong","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2019041121311060500_B22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"issue":"Database issue","key":"2019041121311060500_B23","first-page":"D252","article-title":"MiRGator v3.0: a microRNA portal for deep sequencing, expression profiling and mRNA targeting","volume":"41","author":"Cho","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"2019041121311060500_B24","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/gb-2010-11-8-r90","article-title":"Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites","volume":"11","author":"Betel","year":"2010","journal-title":"Genome Biol"},{"issue":"5985","key":"2019041121311060500_B25","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.1189123","article-title":"MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis","volume":"328","author":"Najafi-Shoushtari","year":"2010","journal-title":"Science"},{"issue":"3","key":"2019041121311060500_B26","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2337\/db11-0944","article-title":"miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets","volume":"61","author":"Wijesekara","year":"2012","journal-title":"Diabetes"},{"key":"2019041121311060500_B27","first-page":"3756","article-title":"MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein","volume-title":"Biochim Biophys Acta","author":"Kuo","year":"2013"},{"issue":"3","key":"2019041121311060500_B28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bone.2005.04.035","article-title":"Expression of the zinc transporter ZIP1 in osteoclasts","volume":"37","author":"Khadeer","year":"2005","journal-title":"Bone"},{"issue":"6","key":"2019041121311060500_B29","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/jcb.20506","article-title":"Effects of parathyroid hormone on Wnt signaling pathway in bone","volume":"95","author":"Kulkarni","year":"2005","journal-title":"J Cell Biochem"},{"issue":"11","key":"2019041121311060500_B30","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1002\/art.23954","article-title":"Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization","volume":"58","author":"Yao","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"6","key":"2019041121311060500_B31","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1365-2265.2009.03728.x","article-title":"The effect of teriparatide on serum Dickkopf-1 levels in postmenopausal women with established osteoporosis","volume":"72","author":"Anastasilakis","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2019041121311060500_B32","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1210\/jc.2010-2552","article-title":"The waning of teriparatide effect on bone formation markers in postmenopausal osteoporosis is associated with increasing serum levels of DKK1","volume":"96","author":"Gatti","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019041121311060500_B33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1210\/me.2002-0225","article-title":"Parathyroid hormone bone anabolic action requires Cbfa1\/Runx2-dependent signaling","volume":"17","author":"Krishnan","year":"2003","journal-title":"Mol Endocrinol"},{"issue":"24","key":"2019041121311060500_B34","doi-asserted-by":"crossref","first-page":"16347","DOI":"10.1074\/jbc.M603439200","article-title":"Cyclin D1-cdk4 induce runx2 ubiquitination and degradation","volume":"281","author":"Shen","year":"2006","journal-title":"J Biol Chem"},{"issue":"6","key":"2019041121311060500_B35","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bone.2007.03.017","article-title":"Molecular and cellular mechanisms of the anabolic effect of intermittent PTH","volume":"40","author":"Jilka","year":"2007","journal-title":"Bone"},{"issue":"4","key":"2019041121311060500_B36","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1074\/jbc.M409846200","article-title":"Parathyroid hormone uses multiple mechanisms to arrest the cell cycle progression of osteoblastic cells from G1 to S phase","volume":"280","author":"Qin","year":"2005","journal-title":"J Biol Chem"},{"issue":"4","key":"2019041121311060500_B37","doi-asserted-by":"crossref","first-page":"e34641","DOI":"10.1371\/journal.pone.0034641","article-title":"MiR-133a in human circulating monocytes: a potential biomarker associated with postmenopausal osteoporosis","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"2019041121311060500_B38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bone.2015.05.027","article-title":"Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation","volume":"79","author":"Weilner","year":"2015","journal-title":"Bone"},{"issue":"5","key":"2019041121311060500_B39","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1515\/cclm-2013-0770","article-title":"Epigenetic mechanisms in bone","volume":"52","author":"Vrta\u010dnik","year":"2014","journal-title":"Clin Chem Lab Med"},{"issue":"4","key":"2019041121311060500_B40","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s40291-017-0272-1","article-title":"The utility of biomarkers in osteoporosis management","volume":"21","author":"Garnero","year":"2017","journal-title":"Mol Diagn Ther"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/103\/3\/1206\/24262997\/jc.2017-02406.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T09:43:33Z","timestamp":1555062213000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/103\/3\/1206\/4772360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,22]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,12,22]]},"published-print":{"date-parts":[[2018,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-02406","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3]]},"published":{"date-parts":[[2017,12,22]]}}}