{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:35:35Z","timestamp":1789918535599,"version":"4.0.1"},"reference-count":66,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"DOI":"10.1210\/jc.2017-02585","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T14:01:05Z","timestamp":1519912865000},"page":"1985-1996","source":"Crossref","is-referenced-by-count":65,"title":["Altered MicroRNA Profile in Osteoporosis Caused by Impaired WNT Signaling"],"prefix":"10.1210","volume":"103","author":[{"given":"Riikka E","family":"M\u00e4kitie","sequence":"first","affiliation":[{"name":"Folkh\u00e4lsan Institute of Genetics and University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hackl","sequence":"additional","affiliation":[{"name":"TAmiRNA GmbH, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Niinim\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Children and Adolescents, Oulu University Hospital, and PEDEGO Research Unit, University of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakari","family":"Kakko","sequence":"additional","affiliation":[{"name":"Internal Medicine and Clinical Research Center, University of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Grillari","sequence":"additional","affiliation":[{"name":"Christian Doppler Laboratory on Biotechnology of Skin Aging, Department of Biotechnology, University of Natural Resources and Life Sciences Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Folkh\u00e4lsan Institute of Genetics and University of Helsinki, Helsinki, Finland"},{"name":"Children\u2019s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Center for Molecular Medicine, Karolinska Institutet and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"issue":"2","key":"2019041117352514700_B1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11914-013-0143-6","article-title":"MicroRNA functions in osteogenesis and dysfunctions in osteoporosis","volume":"11","author":"van Wijnen","year":"2013","journal-title":"Curr Osteoporos Rep"},{"issue":"3","key":"2019041117352514700_B2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00774-013-0537-7","article-title":"MicroRNAs regulate bone metabolism","volume":"32","author":"Zhao","year":"2014","journal-title":"J Bone Miner Metab"},{"issue":"2","key":"2019041117352514700_B3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"7545","key":"2019041117352514700_B4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature14346","article-title":"Primary transcripts of microRNAs encode regulatory peptides","volume":"520","author":"Lauressergues","year":"2015","journal-title":"Nature"},{"issue":"11","key":"2019041117352514700_B5","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","article-title":"Human microRNA targets","volume":"2","author":"John","year":"2004","journal-title":"PLoS Biol"},{"issue":"4","key":"2019041117352514700_B6","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nrendo.2011.234","article-title":"MicroRNA control of bone formation and homeostasis","volume":"8","author":"Lian","year":"2012","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"2019041117352514700_B7","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/stem.1615","article-title":"MicroRNA-34a inhibits osteoblast differentiation and in vivo bone formation of human stromal stem cells","volume":"32","author":"Chen","year":"2014","journal-title":"Stem Cells"},{"issue":"1","key":"2019041117352514700_B8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbrc.2014.02.058","article-title":"Effects of miR-31 on the osteogenesis of human mesenchymal stem cells","volume":"446","author":"Xie","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"2019041117352514700_B9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/acel.12484","article-title":"Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells","volume":"15","author":"Weilner","year":"2016","journal-title":"Aging Cell"},{"issue":"1","key":"2019041117352514700_B10","doi-asserted-by":"crossref","first-page":"20121","DOI":"10.1038\/srep20121","article-title":"H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA","volume":"6","author":"Liang","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"2019041117352514700_B11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ijos.2015.22","article-title":"The role of microRNAs in bone remodeling","volume":"7","author":"Jing","year":"2015","journal-title":"Int J Oral Sci"},{"key":"2019041117352514700_B12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mce.2015.10.015","article-title":"Circulating microRNAs as novel biomarkers for bone diseases: complex signatures for multifactorial diseases","volume":"432","author":"Hackl","year":"2016","journal-title":"Mol Cell Endocrinol"},{"issue":"12","key":"2019041117352514700_B13","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/jbmr.2897","article-title":"Serum miRNA signatures are indicative of skeletal fractures in postmenopausal women with and without type 2 diabetes and influence osteogenic and adipogenic differentiation of adipose tissue-derived mesenchymal stem cells in vitro","volume":"31","author":"Heilmeier","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2019041117352514700_B14","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1210\/jc.2016-2365","article-title":"Circulating microRNA signatures in patients with idiopathic and postmenopausal osteoporosis and fragility fractures","volume":"101","author":"Kocijan","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2019041117352514700_B15","doi-asserted-by":"crossref","first-page":"e97098","DOI":"10.1371\/journal.pone.0097098","article-title":"MiR-422a as a potential cellular microRNA biomarker for postmenopausal osteoporosis","volume":"9","author":"Cao","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"2019041117352514700_B16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/1354750X.2014.935957","article-title":"Plasma miRNA levels correlate with sensitivity to bone mineral density in postmenopausal osteoporosis patients","volume":"19","author":"Li","year":"2014","journal-title":"Biomarkers"},{"issue":"9","key":"2019041117352514700_B17","doi-asserted-by":"crossref","first-page":"e3148","DOI":"10.1371\/journal.pone.0003148","article-title":"Serum microRNAs are promising novel biomarkers","volume":"3","author":"Gilad","year":"2008","journal-title":"PLoS One"},{"issue":"4","key":"2019041117352514700_B18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","article-title":"LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development","volume":"107","author":"Gong","year":"2001","journal-title":"Cell"},{"issue":"7","key":"2019041117352514700_B19","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1101\/gr.3437105","article-title":"Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease","volume":"15","author":"Loots","year":"2005","journal-title":"Genome Res"},{"issue":"5","key":"2019041117352514700_B20","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/hmg\/10.5.537","article-title":"Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)","volume":"10","author":"Balemans","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"19","key":"2019041117352514700_B21","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1056\/NEJMoa1215458","article-title":"WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta","volume":"368","author":"Laine","year":"2013","journal-title":"N Engl J Med"},{"issue":"9","key":"2019041117352514700_B22","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/jbmr.2841","article-title":"Skeletal characteristics of WNT1 osteoporosis in children and young adults","volume":"31","author":"M\u00e4kitie","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2019041117352514700_B23","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1080\/15476286.2015.1094600","article-title":"Downregulation of microRNA-152 contributes to high expression of DKK1 in multiple myeloma","volume":"12","author":"Xu","year":"2015","journal-title":"RNA Biol"},{"issue":"8","key":"2019041117352514700_B24","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/jbmr.377","article-title":"Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1","volume":"26","author":"Zhang","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2019041117352514700_B25","doi-asserted-by":"crossref","first-page":"e845","DOI":"10.1038\/cddis.2013.356","article-title":"miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6","volume":"4","author":"Wang","year":"2013","journal-title":"Cell Death Dis"},{"issue":"2","key":"2019041117352514700_B26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbrc.2010.08.031","article-title":"miR-27 promotes osteoblast differentiation by modulating Wnt signaling","volume":"402","author":"Wang","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"2019041117352514700_B27","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3892\/mmr.2012.1207","article-title":"miR\u2011142\u20113p promotes osteoblast differentiation by modulating Wnt signaling","volume":"7","author":"Hu","year":"2013","journal-title":"Mol Med Rep"},{"issue":"3","key":"2019041117352514700_B28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1530\/JME-14-0013","article-title":"miR-135a-5p inhibits 3T3-L1 adipogenesis through activation of canonical Wnt\/\u03b2-catenin signaling","volume":"52","author":"Chen","year":"2014","journal-title":"J Mol Endocrinol"},{"issue":"10","key":"2019041117352514700_B29","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.3390\/ijms12106733","article-title":"The role of microRNAs in the biology of rare diseases","volume":"12","author":"Salvatore","year":"2011","journal-title":"Int J Mol Sci"},{"key":"2019041117352514700_B30","doi-asserted-by":"crossref","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2019041117352514700_B31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bone.2017.04.001","article-title":"Impaired WNT signaling and the spine-heterozygous WNT1 mutation causes severe age-related spinal pathology","volume":"101","author":"M\u00e4kitie","year":"2017","journal-title":"Bone"},{"issue":"9","key":"2019041117352514700_B32","doi-asserted-by":"crossref","first-page":"e24145","DOI":"10.1371\/journal.pone.0024145","article-title":"Haemolysis during sample preparation alters microRNA content of plasma","volume":"6","author":"Kirschner","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"2019041117352514700_B33","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ymeth.2012.09.015","article-title":"Assessing sample and miRNA profile quality in serum and plasma or other biofluids","volume":"59","author":"Blondal","year":"2013","journal-title":"Methods"},{"key":"2019041117352514700_B34","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"issue":"1","key":"2019041117352514700_B35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.canlet.2013.06.027","article-title":"Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22","volume":"340","author":"Tang","year":"2013","journal-title":"Cancer Lett"},{"issue":"2","key":"2019041117352514700_B36","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1182\/blood-2008-09-179150","article-title":"MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation","volume":"114","author":"Hashimi","year":"2009","journal-title":"Blood"},{"issue":"10","key":"2019041117352514700_B37","doi-asserted-by":"crossref","first-page":"17191","DOI":"10.18632\/oncotarget.15228","article-title":"MiR-34a promotes DCs development and inhibits their function on T cell activation by targeting WNT1","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"2019041117352514700_B38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.amjms.2016.05.002","article-title":"MiR-34a inhibits breast cancer proliferation and progression by targeting Wnt1 in Wnt\/\u03b2-catenin signaling pathway","volume":"352","author":"Si","year":"2016","journal-title":"Am J Med Sci"},{"issue":"1","key":"2019041117352514700_B39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1479-5876-11-201","article-title":"The clinical utility of bone marker measurements in osteoporosis","volume":"11","author":"Wheater","year":"2013","journal-title":"J Transl Med"},{"issue":"2","key":"2019041117352514700_B40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1359\/jbmr.091006","article-title":"Bone turnover markers and prediction of fracture: a prospective follow-up study of 1040 elderly women for a mean of 9 years","volume":"25","author":"Ivaska","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2019041117352514700_B41","doi-asserted-by":"crossref","first-page":"e34641","DOI":"10.1371\/journal.pone.0034641","article-title":"MiR-133a in human circulating monocytes: a potential biomarker associated with postmenopausal osteoporosis","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"2019041117352514700_B42","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1002\/art.37948","article-title":"MicroRNA-29a protects against glucocorticoid-induced bone loss and fragility in rats by orchestrating bone acquisition and resorption","volume":"65","author":"Wang","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2019041117352514700_B43","first-page":"131","volume-title":"Res.","author":"Ding","year":"2015"},{"key":"2019041117352514700_B44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bone.2015.05.027","article-title":"Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation","volume":"79","author":"Weilner","year":"2015","journal-title":"Bone"},{"issue":"1","key":"2019041117352514700_B45","doi-asserted-by":"crossref","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J Extracell Vesicles"},{"issue":"7515","key":"2019041117352514700_B46","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13375","article-title":"miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2","volume":"512","author":"Krzeszinski","year":"2014","journal-title":"Nature"},{"key":"2019041117352514700_B47","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00508-016-1141-3","article-title":"MiR-148a the epigenetic regulator of bone homeostasis is increased in plasma of osteoporotic postmenopausal women","volume":"128","author":"Bedene","year":"2016","journal-title":"Wien Klin Wochenschr"},{"issue":"10","key":"2019041117352514700_B48","doi-asserted-by":"crossref","first-page":"e48086","DOI":"10.1371\/journal.pone.0048086","article-title":"Modulation of the osteosarcoma expression phenotype by microRNAs","volume":"7","author":"Naml\u00f8s","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"2019041117352514700_B49","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.bbadis.2015.08.003","article-title":"High inorganic phosphate concentration inhibits osteoclastogenesis by modulating miR-223","volume":"1852","author":"M\u2019Baya-Moutoula","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"2019041117352514700_B50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/jre.12017","article-title":"Expression profiling of microRNAs in RAW264.7 cells treated with a combination of tumor necrosis factor alpha and RANKL during osteoclast differentiation","volume":"48","author":"Kagiya","year":"2013","journal-title":"J Periodontal Res"},{"issue":"4","key":"2019041117352514700_B51","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/jcb.21335","article-title":"MicroRNA-223 is a key factor in osteoclast differentiation","volume":"101","author":"Sugatani","year":"2007","journal-title":"J Cell Biochem"},{"issue":"10","key":"2019041117352514700_B52","doi-asserted-by":"crossref","first-page":"19433","DOI":"10.3390\/molecules201019433","article-title":"The multiple roles of microRNA-223 in regulating bone metabolism","volume":"20","author":"Xie","year":"2015","journal-title":"Molecules"},{"issue":"1-2","key":"2019041117352514700_B53","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11010-013-1957-3","article-title":"MiR-143 suppresses osteogenic differentiation by targeting Osterix","volume":"390","author":"Li","year":"2014","journal-title":"Mol Cell Biochem"},{"issue":"11","key":"2019041117352514700_B54","first-page":"14241","article-title":"Effect of miR-143 on the apoptosis of osteosarcoma cells","volume":"8","author":"Liu","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"5","key":"2019041117352514700_B55","doi-asserted-by":"crossref","first-page":"R102","DOI":"10.1186\/ar4282","article-title":"miR-31 controls osteoclast formation and bone resorption by targeting RhoA","volume":"15","author":"Mizoguchi","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"2019041117352514700_B56","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.gene.2013.06.021","article-title":"MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31","volume":"527","author":"Bagl\u00eco","year":"2013","journal-title":"Gene"},{"issue":"12","key":"2019041117352514700_B57","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1039\/c1mb05041a","article-title":"Comprehensive miRNome and in silico analyses identify the Wnt signaling pathway to be altered in the diabetic liver","volume":"7","author":"Kaur","year":"2011","journal-title":"Mol Biosyst"},{"issue":"7","key":"2019041117352514700_B58","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.4161\/cc.19618","article-title":"MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling","volume":"11","author":"Cha","year":"2012","journal-title":"Cell Cycle"},{"issue":"10","key":"2019041117352514700_B59","doi-asserted-by":"crossref","first-page":"e13764","DOI":"10.1371\/journal.pone.0013764","article-title":"Cigarette smoke induces C\/EBP-\u03b2-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells","volume":"5","author":"Xi","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"2019041117352514700_B60","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13287-015-0179-x","article-title":"Differentially expressed microRNAs in bone marrow mesenchymal stem cell-derived microvesicles in young and older rats and their effect on tumor growth factor-\u03b21-mediated epithelial-mesenchymal transition in HK2 cells","volume":"6","author":"Wang","year":"2015","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"2019041117352514700_B61","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12967-017-1213-9","article-title":"Differential expression of microRNAs following cardiopulmonary bypass in children with congenital heart diseases","volume":"15","author":"Abu-Halima","year":"2017","journal-title":"J Transl Med"},{"issue":"11","key":"2019041117352514700_B62","doi-asserted-by":"crossref","first-page":"e79805","DOI":"10.1371\/journal.pone.0079805","article-title":"MicroRNA and mRNA signatures in ischemia reperfusion injury in heart transplantation","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS One"},{"issue":"20","key":"2019041117352514700_B63","doi-asserted-by":"crossref","first-page":"29321","DOI":"10.18632\/oncotarget.8722","article-title":"Can the microRNA expression profile help to identify novel targets for zoledronic acid in breast cancer","volume":"7","author":"Fanale","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"2019041117352514700_B64","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nm.3026","article-title":"miR-214 targets ATF4 to inhibit bone formation","volume":"19","author":"Wang","year":"2013","journal-title":"Nat Med"},{"issue":"12","key":"2019041117352514700_B65","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrc3166","article-title":"MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy","volume":"11","author":"Kasinski","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"2019041117352514700_B66","doi-asserted-by":"crossref","first-page":"42702","DOI":"10.1038\/srep42702","article-title":"Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy","volume":"7","author":"Kangas","year":"2017","journal-title":"Sci Rep"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/103\/5\/1985\/24795088\/jc.2017-02585.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T02:06:00Z","timestamp":1555034760000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/103\/5\/1985\/4916912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,1]]},"references-count":66,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,3,1]]},"published-print":{"date-parts":[[2018,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-02585","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,5]]},"published":{"date-parts":[[2018,3,1]]}}}