{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:59:43Z","timestamp":1774987183698,"version":"3.50.1"},"reference-count":15,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1210\/jc.2017-02644","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T18:10:13Z","timestamp":1530555013000},"page":"3215-3224","source":"Crossref","is-referenced-by-count":51,"title":["GSK2881078, a SARM, Produces Dose-Dependent Increases in Lean Mass in Healthy Older Men and Women"],"prefix":"10.1210","volume":"103","author":[{"given":"David","family":"Neil","sequence":"first","affiliation":[{"name":"Muscle Metabolism Discovery Performance Unit, GlaxoSmithKline, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard V","family":"Clark","sequence":"additional","affiliation":[{"name":"Muscle Metabolism Discovery Performance Unit, GlaxoSmithKline, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mindy","family":"Magee","sequence":"additional","affiliation":[{"name":"Muscle Metabolism Discovery Performance Unit, GlaxoSmithKline, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Billiard","sequence":"additional","affiliation":[{"name":"Muscle Metabolism Discovery Performance Unit, GlaxoSmithKline, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Chan","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Mississauga, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyu","family":"Xue","sequence":"additional","affiliation":[{"name":"Genomic Medicine, PAREXEL, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Russell","sequence":"additional","affiliation":[{"name":"Edgewise Therapeutics, Boulder, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"issue":"3","key":"key\n\t\t\t\t20180906135334_B1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/ncpendmet0120","article-title":"Drug insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging","volume":"2","author":"Bhasin","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab"},{"issue":"3","key":"key\n\t\t\t\t20180906135334_B2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/156802606776173456","article-title":"Selective androgen receptor modulators in drug discovery: medicinal chemistry and therapeutic potential","volume":"6","author":"Cadilla","year":"2006","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"key\n\t\t\t\t20180906135334_B3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3181\/00379727-83-20301","article-title":"Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method","volume":"83","author":"Hershberger","year":"1953","journal-title":"Proc Soc Exp Biol Med"},{"issue":"10","key":"key\n\t\t\t\t20180906135334_B4","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1111\/bcp.13316","article-title":"Safety, pharmacokinetics and pharmacological effects of the selective androgen receptor modulator, GSK2881078, in healthy men and postmenopausal women","volume":"83","author":"Clark","year":"2017","journal-title":"Br J Clin Pharmacol"},{"issue":"6","key":"key\n\t\t\t\t20180906135334_B5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12603-013-0335-x","article-title":"A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia","volume":"17","author":"Papanicolaou","year":"2013","journal-title":"J Nutr Health Aging"},{"issue":"1","key":"key\n\t\t\t\t20180906135334_B6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/gerona\/gls078","article-title":"The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men","volume":"68","author":"Basaria","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"key\n\t\t\t\t20180906135334_B7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s13539-011-0034-6","article-title":"The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial","volume":"2","author":"Dalton","year":"2011","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"key\n\t\t\t\t20180906135334_B8","doi-asserted-by":"crossref","first-page":"E1172","DOI":"10.1152\/ajpendo.2001.281.6.E1172","article-title":"Testosterone dose-response relationships in healthy young men","volume":"281","author":"Bhasin","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"8","key":"key\n\t\t\t\t20180906135334_B9","first-page":"441","article-title":"Testosterone suppression of the HPT axis","volume":"45","author":"MacIndoe","year":"1997","journal-title":"J Investig Med"},{"issue":"2","key":"key\n\t\t\t\t20180906135334_B10","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1210\/jc.2004-1184","article-title":"Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle","volume":"90","author":"Bhasin","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"key\n\t\t\t\t20180906135334_B11","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/jama.2012.227","article-title":"Effect of testosterone supplementation with and without a dual 5\u03b1-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial","volume":"307","author":"Bhasin","year":"2012","journal-title":"JAMA"},{"issue":"10","key":"key\n\t\t\t\t20180906135334_B12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.7326\/0003-4819-153-10-201011160-00004","article-title":"Long-term effects of dihydrotestosterone treatment on prostate growth in healthy, middle-aged men without prostate disease: a randomized, placebo-controlled trial","volume":"153","author":"Idan","year":"2010","journal-title":"Ann Intern Med"},{"issue":"11","key":"key\n\t\t\t\t20180906135334_B13","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1517\/14740338.2015.1094052","article-title":"Comparative safety evaluation of selective androgen receptor modulators and anabolic androgenic steroids","volume":"14","author":"Choi","year":"2015","journal-title":"Expert Opin Drug Saf"},{"issue":"4","key":"key\n\t\t\t\t20180906135334_B14","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/hep.22109","article-title":"Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease","volume":"47","author":"Kim","year":"2008","journal-title":"Hepatology"},{"issue":"3","key":"key\n\t\t\t\t20180906135334_B15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/path.1711170307","article-title":"Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters","volume":"117","author":"Portmann","year":"1975","journal-title":"J Pathol"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/103\/9\/3215\/25686032\/jc.2017-02644.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T07:46:02Z","timestamp":1571557562000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/103\/9\/3215\/5047294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,2]]},"references-count":15,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,7,2]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2017-02644","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,7,2]]}}}