{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:44:08Z","timestamp":1777434248221,"version":"3.51.4"},"reference-count":39,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>We previously demonstrated that insulin infusion altered metabolite concentrations in cerebral tissues assessed with proton magnetic resonance spectroscopy (1H-MRS) in young subjects with high insulin sensitivity, but not in those with low insulin sensitivity. Fat overload is an important factor leading to insulin resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The purpose of the current study was to examine the effect of elevated circulating free fatty acid (FFA) levels on metabolites in cerebral tissues assessed with 1H-MRS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>The study group comprised 10 young, healthy male subjects. 1H-MRS was performed at baseline and after 4-hour Intralipid (Fresenius Kabi)\/heparin or saline infusions administered in random order. Voxels were positioned in the left frontal lobe, left temporal lobe, and hippocampus. The ratios of N-acetylaspartate (NAA), choline (Cho)-containing compounds, myo-inositol (mI), and glutamate\/glutamine\/\u03b3-aminobutyric acid complex (Glx) to creatine (Cr) and nonsuppressed water signal were determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Intralipid\/heparin infusion resulted in a significant increase in circulating FFAs (P &amp;lt; 0.0001). Significant changes in brain neurometabolite concentrations in response to Intralipid\/heparin infusion were increases in frontal mI\/Cr (P = 0.041) and mI\/H2O (P = 0.037), decreases in frontal and hippocampal Glx\/Cr (P = 0.018 and P = 0.015, respectively) and Glx\/H2O (P = 0.03 and P = 0.067, respectively), and a decrease in hippocampal NAA\/Cr (P = 0.007) and NAA\/H2O (P = 0.019). No changes in neurometabolites were observed during the saline infusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Acute circulating FFA elevation influenced cerebral metabolites in healthy humans and lipid-induced insulin resistance could be partly responsible for these effects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/jc.2018-00107","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T18:04:29Z","timestamp":1524247469000},"page":"2563-2570","source":"Crossref","is-referenced-by-count":6,"title":["Intralipid\/Heparin Infusion Alters Brain Metabolites Assessed With 1H-MRS Spectroscopy in Young Healthy Men"],"prefix":"10.1210","volume":"103","author":[{"given":"Monika","family":"Karczewska-Kupczewska","sequence":"first","affiliation":[{"name":"Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food 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