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ISI, but not estimated 24-hour insulin level, correlated positively with morning free testosterone level when correcting for estimated 24-hour LH level and Tanner stage (rs = 0.68, P = 0.046). The correlation between estimated 24-hour LH and free testosterone levels approached significance after adjusting for estimated 24-hour insulin level and Tanner stage (rs = 0.63, P = 0.067). Estimated 24-hour insulin level did not correlate with free testosterone level after adjusting for estimated 24-hour LH level and Tanner stage (rs = 0.47, P = 0.20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In insulin-resistant obese girls with hyperinsulinemia, free testosterone levels correlated positively with insulin sensitivity and, likely, circulating LH concentrations but not with circulating insulin levels. In the setting of relatively uniform hyperinsulinemia, variable steroidogenic-cell insulin sensitivity may correlate with metabolic insulin sensitivity and contribute to variable free testosterone concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1210\/jc.2018-00131","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T18:04:26Z","timestamp":1524247466000},"page":"2571-2582","source":"Crossref","is-referenced-by-count":9,"title":["Insulin Resistance, Hyperinsulinemia, and LH: Relative Roles in Peripubertal Obesity-Associated Hyperandrogenemia"],"prefix":"10.1210","volume":"103","author":[{"given":"Christine M","family":"Burt Solorzano","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia"},{"name":"Center for Research in Reproduction, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy D","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor G","family":"Hutchens","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessicah S","family":"Collins","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T","family":"Patrie","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C","family":"Marshall","sequence":"additional","affiliation":[{"name":"Center for Research in Reproduction, University of Virginia School of Medicine, Charlottesville, Virginia"},{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R","family":"McCartney","sequence":"additional","affiliation":[{"name":"Center for Research in Reproduction, University of Virginia School of Medicine, Charlottesville, Virginia"},{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"issue":"5","key":"2019081405450575200_B1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr Rev"},{"issue":"1","key":"2019081405450575200_B2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMcp1514916","article-title":"Clinical practice. 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